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Protein

Chain length determinant protein

Gene

wzzB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7090-MONOMER.
ECOL316407:JW5836-MONOMER.
UniPathwayiUPA00030.

Names & Taxonomyi

Protein namesi
Recommended name:
Chain length determinant protein
Alternative name(s):
Polysaccharide antigen chain regulator
Gene namesi
Name:wzzB
Synonyms:cld, rol, wzz
Ordered Locus Names:b2027, JW5836
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13406. wzzB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 295PeriplasmicSequence analysisAdd BLAST243
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 326CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659921 – 326Chain length determinant proteinAdd BLAST326

Proteomic databases

EPDiP76372.
PaxDbiP76372.
PRIDEiP76372.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4261360. 320 interactors.
STRINGi511145.b2027.

Structurei

3D structure databases

ProteinModelPortaliP76372.
SMRiP76372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the WzzB/Cld/Rol family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108KPN. Bacteria.
COG3765. LUCA.
HOGENOMiHOG000121918.
InParanoidiP76372.
KOiK05789.
OMAiDNIALRM.
PhylomeDBiP76372.

Family and domain databases

InterProiIPR003856. LipoPS_biosynth.
[Graphical view]
PfamiPF02706. Wzz. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVENNNVSG QNHDPEQIDL IDLLVQLWRG KMTIIISVIV AIALAIGYLA
60 70 80 90 100
VAKEKWTSTA IITQPDVGQI AGYNNAMNVI YGQAAPKVSD LQETLIGRFS
110 120 130 140 150
SAFSALAETL DNQEEREKLT IEPSVKNQQL PLTVSYVGQT AEGAQMKLAQ
160 170 180 190 200
YIQQVDDKVN QELEKDLKDN IALGRKNLQD SLRTQEVVAQ EQKDLRIRQI
210 220 230 240 250
QEALQYANQA QVTKPQIQQT GEDITQDTLF LLGSEALESM IKHEATRPLV
260 270 280 290 300
FSPNYYQTRQ NLLDIESLKV DDLDIHAYRY VMKPMLPIRR DSPKKAITLI
310 320
LAVLLGGMVG AGIVLGRNAL RNYNAK
Length:326
Mass (Da):36,455
Last modified:July 15, 1998 - v2
Checksum:i9D4DA2A9E5E7E8F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07559 Genomic DNA. Translation: CAA68844.1.
U00096 Genomic DNA. Translation: AAC75088.2.
AP009048 Genomic DNA. Translation: BAA15859.1.
RefSeqiNP_416531.4. NC_000913.3.
WP_001393575.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75088; AAC75088; b2027.
BAA15859; BAA15859; BAA15859.
GeneIDi946553.
KEGGiecj:JW5836.
eco:b2027.
PATRICi32119389. VBIEscCol129921_2104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07559 Genomic DNA. Translation: CAA68844.1.
U00096 Genomic DNA. Translation: AAC75088.2.
AP009048 Genomic DNA. Translation: BAA15859.1.
RefSeqiNP_416531.4. NC_000913.3.
WP_001393575.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76372.
SMRiP76372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261360. 320 interactors.
STRINGi511145.b2027.

Proteomic databases

EPDiP76372.
PaxDbiP76372.
PRIDEiP76372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75088; AAC75088; b2027.
BAA15859; BAA15859; BAA15859.
GeneIDi946553.
KEGGiecj:JW5836.
eco:b2027.
PATRICi32119389. VBIEscCol129921_2104.

Organism-specific databases

EchoBASEiEB3182.
EcoGeneiEG13406. wzzB.

Phylogenomic databases

eggNOGiENOG4108KPN. Bacteria.
COG3765. LUCA.
HOGENOMiHOG000121918.
InParanoidiP76372.
KOiK05789.
OMAiDNIALRM.
PhylomeDBiP76372.

Enzyme and pathway databases

UniPathwayiUPA00030.
BioCyciEcoCyc:G7090-MONOMER.
ECOL316407:JW5836-MONOMER.

Miscellaneous databases

PROiP76372.

Family and domain databases

InterProiIPR003856. LipoPS_biosynth.
[Graphical view]
PfamiPF02706. Wzz. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWZZB_ECOLI
AccessioniPrimary (citable) accession number: P76372
Secondary accession number(s): O07997, O07998, P77049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.