UniProtKB - P76364 (CBEA_ECOLI)
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Protein
Cytoskeleton bundling-enhancing antitoxin CbeA
Gene
cbeA
Organism
Escherichia coli (strain K12)
Status
Functioni
Antitoxin component of a type IV toxin-antitoxin (TA) system. Labile antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed:14594833). The intergenic region was not found to be necessary in another study (PubMed:22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape.2 Publications
Cofactori
Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 86 | Magnesium; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 88 | Magnesium; via amide nitrogen and carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 102 | Magnesium1 Publication | 1 |
GO - Molecular functioni
- cytoskeletal protein binding Source: EcoCyc
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of cytoskeleton organization Source: EcoCyc
Keywordsi
Biological process | Toxin-antitoxin system |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7084-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cytoskeleton bundling-enhancing antitoxin CbeACuratedAlternative name(s): Antitoxin CbeA Antitoxin YeeU1 Publication |
Gene namesi | Name:cbeA Synonyms:yeeU Ordered Locus Names:b2004, JW1986 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Organism-specific databases
EcoGenei | EG13388 cbeA |
Subcellular locationi
- Cytoplasm Curated
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169115 | 1 – 122 | Cytoskeleton bundling-enhancing antitoxin CbeAAdd BLAST | 122 |
Proteomic databases
PaxDbi | P76364 |
PRIDEi | P76364 |
Interactioni
Subunit structurei
Homodimer (Probable). Interacts with polymerized and monomeric MreB and polymerized FtsZ.Curated2 Publications
Binary interactionsi
GO - Molecular functioni
- cytoskeletal protein binding Source: EcoCyc
Protein-protein interaction databases
BioGridi | 426151912 interactors. |
IntActi | P76364 6 interactors. |
STRINGi | 316385.ECDH10B_2150 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 27 – 37 | Combined sources | 11 | |
Beta strandi | 40 – 42 | Combined sources | 3 | |
Helixi | 45 – 47 | Combined sources | 3 | |
Beta strandi | 48 – 52 | Combined sources | 5 | |
Helixi | 56 – 79 | Combined sources | 24 | |
Beta strandi | 80 – 82 | Combined sources | 3 | |
Beta strandi | 90 – 94 | Combined sources | 5 | |
Beta strandi | 97 – 102 | Combined sources | 6 | |
Beta strandi | 107 – 116 | Combined sources | 10 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H28 | X-ray | 2.10 | A/B | 1-122 | [»] | |
ProteinModelPortali | P76364 | |||||
SMRi | P76364 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P76364 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CbeA/YafW/YfjZ antitoxin family.Curated
Phylogenomic databases
eggNOGi | ENOG4105MAW Bacteria ENOG4111V4B LUCA |
HOGENOMi | HOG000290944 |
KOi | K18838 |
OMAi | NNDRTWW |
PhylomeDBi | P76364 |
Family and domain databases
InterProi | View protein in InterPro IPR009320 Antitoxin_CbeA IPR038025 CbeA_sf |
Pfami | View protein in Pfam PF06154 CbeA_antitoxin, 1 hit |
SUPFAMi | SSF143737 SSF143737, 1 hit |
i Sequence
Sequence statusi: Complete.
P76364-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDTLPGTTL PDDNHDRPWW GLPCTVTPCF GARLVQEGNR LHYLADRAGI
60 70 80 90 100
RGLFSDADAY HLDQAFPLLM KQLELMLTSG ELNPRHQHTV TLYAKGLTCK
110 120
ADTLSSCDYV YLAVYPTPEM KN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75065.1 AP009048 Genomic DNA Translation: BAA15827.1 |
PIRi | C64965 |
RefSeqi | NP_416508.1, NC_000913.3 WP_001285584.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75065; AAC75065; b2004 BAA15827; BAA15827; BAA15827 |
GeneIDi | 946510 |
KEGGi | ecj:JW1986 eco:b2004 |
PATRICi | fig|1411691.4.peg.249 |
Similar proteinsi
Entry informationi
Entry namei | CBEA_ECOLI | |
Accessioni | P76364Primary (citable) accession number: P76364 Secondary accession number(s): O07991, O07994 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |