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Protein

Cytoskeleton bundling-enhancing antitoxin CbeA

Gene

cbeA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antitoxin component of a type IV toxin-antitoxin (TA) system. Labile antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed:14594833). The intergenic region was not found to be necessary in another study (PubMed:22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape.2 Publications

Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86Magnesium; via carbonyl oxygen1 Publication1
Metal bindingi88Magnesium; via amide nitrogen and carbonyl oxygen1 Publication1
Metal bindingi102Magnesium1 Publication1

GO - Molecular functioni

  • cytoskeletal protein binding Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of cytoskeleton organization Source: EcoCyc

Keywordsi

Biological processToxin-antitoxin system
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7084-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoskeleton bundling-enhancing antitoxin CbeACurated
Alternative name(s):
Antitoxin CbeA
Antitoxin YeeU1 Publication
Gene namesi
Name:cbeA
Synonyms:yeeU
Ordered Locus Names:b2004, JW1986
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13388 cbeA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001691151 – 122Cytoskeleton bundling-enhancing antitoxin CbeAAdd BLAST122

Proteomic databases

PaxDbiP76364
PRIDEiP76364

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with polymerized and monomeric MreB and polymerized FtsZ.Curated2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi426151912 interactors.
IntActiP76364 6 interactors.
STRINGi316385.ECDH10B_2150

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 37Combined sources11
Beta strandi40 – 42Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 52Combined sources5
Helixi56 – 79Combined sources24
Beta strandi80 – 82Combined sources3
Beta strandi90 – 94Combined sources5
Beta strandi97 – 102Combined sources6
Beta strandi107 – 116Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H28X-ray2.10A/B1-122[»]
ProteinModelPortaliP76364
SMRiP76364
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76364

Family & Domainsi

Sequence similaritiesi

Belongs to the CbeA/YafW/YfjZ antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105MAW Bacteria
ENOG4111V4B LUCA
HOGENOMiHOG000290944
KOiK18838
OMAiNNDRTWW
PhylomeDBiP76364

Family and domain databases

InterProiView protein in InterPro
IPR009320 Antitoxin_CbeA
IPR038025 CbeA_sf
PfamiView protein in Pfam
PF06154 CbeA_antitoxin, 1 hit
SUPFAMiSSF143737 SSF143737, 1 hit

Sequencei

Sequence statusi: Complete.

P76364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTLPGTTL PDDNHDRPWW GLPCTVTPCF GARLVQEGNR LHYLADRAGI
60 70 80 90 100
RGLFSDADAY HLDQAFPLLM KQLELMLTSG ELNPRHQHTV TLYAKGLTCK
110 120
ADTLSSCDYV YLAVYPTPEM KN
Length:122
Mass (Da):13,684
Last modified:February 1, 1997 - v1
Checksum:iE6F703DEA3D67290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75065.1
AP009048 Genomic DNA Translation: BAA15827.1
PIRiC64965
RefSeqiNP_416508.1, NC_000913.3
WP_001285584.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75065; AAC75065; b2004
BAA15827; BAA15827; BAA15827
GeneIDi946510
KEGGiecj:JW1986
eco:b2004
PATRICifig|1411691.4.peg.249

Similar proteinsi

Entry informationi

Entry nameiCBEA_ECOLI
AccessioniPrimary (citable) accession number: P76364
Secondary accession number(s): O07991, O07994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome