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Protein

Shikimate transporter

Gene

shiA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • shikimate transmembrane transporter activity Source: EcoCyc
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • shikimate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:SHIA-MONOMER.
ECOL316407:JW1962-MONOMER.
MetaCyc:SHIA-MONOMER.

Protein family/group databases

TCDBi2.A.1.6.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate transporter
Gene namesi
Name:shiA
Synonyms:yeeM
Ordered Locus Names:b1981, JW1962
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20205. shiA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 63PeriplasmicSequence analysisAdd BLAST15
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 108CytoplasmicSequence analysisAdd BLAST24
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 132PeriplasmicSequence analysis3
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 167CytoplasmicSequence analysisAdd BLAST14
Transmembranei168 – 188Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini189 – 192PeriplasmicSequence analysis4
Transmembranei193 – 213Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini214 – 254CytoplasmicSequence analysisAdd BLAST41
Transmembranei255 – 275Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini276 – 286PeriplasmicSequence analysisAdd BLAST11
Transmembranei287 – 307Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini308 – 317CytoplasmicSequence analysis10
Transmembranei318 – 337Helical; Name=9Sequence analysisAdd BLAST20
Topological domaini338 – 340PeriplasmicSequence analysis3
Transmembranei341 – 363Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini364 – 386CytoplasmicSequence analysisAdd BLAST23
Transmembranei387 – 407Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini408 – 410PeriplasmicSequence analysis3
Transmembranei411 – 431Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini432 – 438CytoplasmicSequence analysis7

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503361 – 438Shikimate transporterAdd BLAST438

Proteomic databases

PaxDbiP76350.
PRIDEiP76350.

Interactioni

Protein-protein interaction databases

BioGridi4260400. 8 interactors.
STRINGi511145.b1981.

Structurei

3D structure databases

ProteinModelPortaliP76350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CSH. Bacteria.
ENOG410XP7I. LUCA.
HOGENOMiHOG000141611.
InParanoidiP76350.
KOiK08172.
OMAiMMTVWMM.
PhylomeDBiP76350.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004736. Cit_H_symport.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00883. 2A0106. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTLISTRP DEGTLSLSRA RRAALGSFAG AVVDWYDFLL YGITAALVFN
60 70 80 90 100
REFFPQVSPA MGTLAAFATF GVGFLFRPLG GVIFGHFGDR LGRKRMLMLT
110 120 130 140 150
VWMMGIATAL IGILPSFSTI GWWAPILLVT LRAIQGFAVG GEWGGAALLS
160 170 180 190 200
VESAPKNKKA FYSSGVQVGY GVGLLLSTGL VSLISMMTTD EQFLSWGWRI
210 220 230 240 250
PFLFSIVLVL GALWVRNGME ESAEFEQQQH YQAAAKKRIP VIEALLRHPG
260 270 280 290 300
AFLKIIALRL CELLTMYIVT AFALNYSTQN MGLPRELFLN IGLLVGGLSC
310 320 330 340 350
LTIPCFAWLA DRFGRRRVYI TGTLIGTLSA FPFFMALEAQ SIFWIVFFSI
360 370 380 390 400
MLANIAHDMV VCVQQPMFTE MFGASYRYSG AGVGYQVASV VGGGFTPFIA
410 420 430
AALITYFAGN WHSVAIYLLA GCLISAMTAL LMKDSQRA
Length:438
Mass (Da):47,817
Last modified:February 1, 1997 - v1
Checksum:iB7FFBBD5AFDAE8CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88529 Genomic DNA. Translation: AAC46271.1.
U00096 Genomic DNA. Translation: AAC75045.1.
AP009048 Genomic DNA. Translation: BAA15801.1.
PIRiG64962.
RefSeqiNP_416488.1. NC_000913.3.
WP_000378575.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75045; AAC75045; b1981.
BAA15801; BAA15801; BAA15801.
GeneIDi946495.
KEGGiecj:JW1962.
eco:b1981.
PATRICi32119293. VBIEscCol129921_2059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88529 Genomic DNA. Translation: AAC46271.1.
U00096 Genomic DNA. Translation: AAC75045.1.
AP009048 Genomic DNA. Translation: BAA15801.1.
PIRiG64962.
RefSeqiNP_416488.1. NC_000913.3.
WP_000378575.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260400. 8 interactors.
STRINGi511145.b1981.

Protein family/group databases

TCDBi2.A.1.6.6. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP76350.
PRIDEiP76350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75045; AAC75045; b1981.
BAA15801; BAA15801; BAA15801.
GeneIDi946495.
KEGGiecj:JW1962.
eco:b1981.
PATRICi32119293. VBIEscCol129921_2059.

Organism-specific databases

EchoBASEiEB4148.
EcoGeneiEG20205. shiA.

Phylogenomic databases

eggNOGiENOG4105CSH. Bacteria.
ENOG410XP7I. LUCA.
HOGENOMiHOG000141611.
InParanoidiP76350.
KOiK08172.
OMAiMMTVWMM.
PhylomeDBiP76350.

Enzyme and pathway databases

BioCyciEcoCyc:SHIA-MONOMER.
ECOL316407:JW1962-MONOMER.
MetaCyc:SHIA-MONOMER.

Miscellaneous databases

PROiP76350.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004736. Cit_H_symport.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00883. 2A0106. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHIA_ECOLI
AccessioniPrimary (citable) accession number: P76350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.