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Protein

Protein MtfA

Gene

mtfA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of ptsG expression by binding and inactivating Mlc.1 Publication

GO - Molecular functioni

  • aminopeptidase activity Source: EcoCyc
  • metallopeptidase activity Source: InterPro
  • transcription factor binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7063-MONOMER.
ECOL316407:JW1958-MONOMER.
MetaCyc:G7063-MONOMER.

Protein family/group databases

MEROPSiM90.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MtfA
Alternative name(s):
Mlc titration factor A
Gene namesi
Name:mtfA
Synonyms:yeeI
Ordered Locus Names:b1976, JW1958
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13377. mtfA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Protein MtfAPRO_0000169108Add
BLAST

Proteomic databases

PaxDbiP76346.
PRIDEiP76346.

Interactioni

Subunit structurei

Interacts with Mlc with high affinity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
mlcP504562EBI-1126682,EBI-1116104

GO - Molecular functioni

  • transcription factor binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261319. 13 interactions.
IntActiP76346. 19 interactions.
STRINGi511145.b1976.

Structurei

3D structure databases

ProteinModelPortaliP76346.
SMRiP76346. Positions 17-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MtfA family.Curated

Phylogenomic databases

eggNOGiENOG4105EXZ. Bacteria.
COG3228. LUCA.
HOGENOMiHOG000261077.
KOiK09933.
OMAiKEFSTAH.
OrthoDBiEOG6CCH5W.
PhylomeDBiP76346.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
HAMAPiMF_01593. MtfA.
InterProiIPR024079. MetalloPept_cat_dom.
IPR010384. MtfA_fam.
[Graphical view]
PfamiPF06167. Peptidase_M90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKWPWKVQE SAHQTALPWQ EALSIPLLTC LTEQEQSKLV TLAERFLQQK
60 70 80 90 100
RLVPLQGFEL DSLRSCRIAL LFCLPVLELG LEWLDGFHEV LIYPAPFVVD
110 120 130 140 150
DEWEDDIGLV HNQRIVQSGQ SWQQGPIVLN WLDIQDSFDA SGFNLIIHEV
160 170 180 190 200
AHKLDTRNGD RASGVPFIPL REVAGWEHDL HAAMNNIQEE IELVGENAAS
210 220 230 240 250
IDAYAASDPA ECFAVLSEYF FSAPELFAPR FPSLWQRFCQ FYQQDPLQRL
260
HHANDTDSFS ATNVH
Length:265
Mass (Da):30,279
Last modified:December 15, 1998 - v2
Checksum:i198E366587CCF8A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75041.2.
AP009048 Genomic DNA. Translation: BAE76562.1.
RefSeqiNP_416484.2. NC_000913.3.
WP_001302302.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75041; AAC75041; b1976.
BAE76562; BAE76562; BAE76562.
GeneIDi946489.
KEGGiecj:JW1958.
eco:b1976.
PATRICi32119283. VBIEscCol129921_2055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75041.2.
AP009048 Genomic DNA. Translation: BAE76562.1.
RefSeqiNP_416484.2. NC_000913.3.
WP_001302302.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76346.
SMRiP76346. Positions 17-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261319. 13 interactions.
IntActiP76346. 19 interactions.
STRINGi511145.b1976.

Protein family/group databases

MEROPSiM90.001.

Proteomic databases

PaxDbiP76346.
PRIDEiP76346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75041; AAC75041; b1976.
BAE76562; BAE76562; BAE76562.
GeneIDi946489.
KEGGiecj:JW1958.
eco:b1976.
PATRICi32119283. VBIEscCol129921_2055.

Organism-specific databases

EchoBASEiEB3159.
EcoGeneiEG13377. mtfA.

Phylogenomic databases

eggNOGiENOG4105EXZ. Bacteria.
COG3228. LUCA.
HOGENOMiHOG000261077.
KOiK09933.
OMAiKEFSTAH.
OrthoDBiEOG6CCH5W.
PhylomeDBiP76346.

Enzyme and pathway databases

BioCyciEcoCyc:G7063-MONOMER.
ECOL316407:JW1958-MONOMER.
MetaCyc:G7063-MONOMER.

Miscellaneous databases

PROiP76346.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
HAMAPiMF_01593. MtfA.
InterProiIPR024079. MetalloPept_cat_dom.
IPR010384. MtfA_fam.
[Graphical view]
PfamiPF06167. Peptidase_M90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12."
    Becker A.-K., Zeppenfeld T., Staab A., Seitz S., Boos W., Morita T., Aiba H., Mahr K., Titgemeyer F., Jahreis K.
    J. Bacteriol. 188:5439-5449(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MLC.
    Strain: K12.

Entry informationi

Entry nameiMTFA_ECOLI
AccessioniPrimary (citable) accession number: P76346
Secondary accession number(s): Q2MAZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.