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Protein

Protein MtfA

Gene

mtfA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of ptsG expression by binding and inactivating Mlc.1 Publication

GO - Molecular functioni

  • aminopeptidase activity Source: EcoCyc
  • metallopeptidase activity Source: InterPro
  • transcription factor binding Source: EcoCyc

GO - Biological processi

  • negative regulation of DNA binding transcription factor activity Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7063-MONOMER
MetaCyc:G7063-MONOMER

Protein family/group databases

MEROPSiM90.001

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MtfA
Alternative name(s):
Mlc titration factor A
Gene namesi
Name:mtfA
Synonyms:yeeI
Ordered Locus Names:b1976, JW1958
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13377 mtfA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001691081 – 265Protein MtfAAdd BLAST265

Proteomic databases

PaxDbiP76346
PRIDEiP76346

Interactioni

Subunit structurei

Interacts with Mlc with high affinity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
mlcP504562EBI-1126682,EBI-1116104

GO - Molecular functioni

  • transcription factor binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261319, 14 interactors
IntActiP76346, 19 interactors
STRINGi316385.ECDH10B_2119

Structurei

3D structure databases

ProteinModelPortaliP76346
SMRiP76346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MtfA family.Curated

Phylogenomic databases

eggNOGiENOG4105EXZ Bacteria
COG3228 LUCA
HOGENOMiHOG000261077
KOiK09933
OMAiEHSGEAW
PhylomeDBiP76346

Family and domain databases

Gene3Di3.40.390.10, 1 hit
HAMAPiMF_01593 MtfA, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR010384 MtfA_fam
PANTHERiPTHR30164 PTHR30164, 1 hit
PfamiView protein in Pfam
PF06167 Peptidase_M90, 1 hit

Sequencei

Sequence statusi: Complete.

P76346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKWPWKVQE SAHQTALPWQ EALSIPLLTC LTEQEQSKLV TLAERFLQQK
60 70 80 90 100
RLVPLQGFEL DSLRSCRIAL LFCLPVLELG LEWLDGFHEV LIYPAPFVVD
110 120 130 140 150
DEWEDDIGLV HNQRIVQSGQ SWQQGPIVLN WLDIQDSFDA SGFNLIIHEV
160 170 180 190 200
AHKLDTRNGD RASGVPFIPL REVAGWEHDL HAAMNNIQEE IELVGENAAS
210 220 230 240 250
IDAYAASDPA ECFAVLSEYF FSAPELFAPR FPSLWQRFCQ FYQQDPLQRL
260
HHANDTDSFS ATNVH
Length:265
Mass (Da):30,279
Last modified:December 15, 1998 - v2
Checksum:i198E366587CCF8A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75041.2
AP009048 Genomic DNA Translation: BAE76562.1
RefSeqiNP_416484.2, NC_000913.3
WP_001302302.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75041; AAC75041; b1976
BAE76562; BAE76562; BAE76562
GeneIDi946489
KEGGiecj:JW1958
eco:b1976
PATRICifig|1411691.4.peg.274

Similar proteinsi

Entry informationi

Entry nameiMTFA_ECOLI
AccessioniPrimary (citable) accession number: P76346
Secondary accession number(s): Q2MAZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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