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Protein

Probable transcriptional regulatory protein YedW

Gene

yedW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable member of a two-component regulatory system YedW/YedV.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi122 – 220OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST99

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • phosphorelay signal transduction system Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7057-MONOMER.
ECOL316407:JW5322-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transcriptional regulatory protein YedW
Gene namesi
Name:yedW
Ordered Locus Names:b1969, JW5322
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14045. yedW.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000813601 – 223Probable transcriptional regulatory protein YedWAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by YedV.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP76340.
PRIDEiP76340.

Interactioni

Protein-protein interaction databases

BioGridi4260386. 5 interactors.
DIPiDIP-11853N.
IntActiP76340. 2 interactors.
MINTiMINT-1223015.
STRINGi511145.b1969.

Structurei

3D structure databases

ProteinModelPortaliP76340.
SMRiP76340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 115Response regulatoryPROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CK6. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiP76340.
KOiK02483.
OMAiCDVIQTV.
PhylomeDBiP76340.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR006291. PcoR.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
TIGRFAMsiTIGR01387. cztR_silR_copR. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLIEDNQ RTQEWVTQGL SEAGYVIDAV SDGRDGLYLA LKDDYALIIL
60 70 80 90 100
DIMLPGMDGW QILQTLRTAK QTPVICLTAR DSVDDRVRGL DSGANDYLVK
110 120 130 140 150
PFSFSELLAR VRAQLRQHHA LNSTLEISGL RMDSVSHSVS RDNISITLTR
160 170 180 190 200
KEFQLLWLLA SRAGEIIPRT VIASEIWGIN FDSDTNTVDV AIRRLRAKVD
210 220
DPFPEKLIAT IRGMGYSFVA VKK
Length:223
Mass (Da):25,018
Last modified:April 27, 2001 - v2
Checksum:i4A595D7430C2E2B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75035.2.
AP009048 Genomic DNA. Translation: BAA15796.2.
PIRiE64961.
RefSeqiNP_416478.2. NC_000913.3.
WP_001395354.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75035; AAC75035; b1969.
BAA15796; BAA15796; BAA15796.
GeneIDi946486.
KEGGiecj:JW5322.
eco:b1969.
PATRICi32119269. VBIEscCol129921_2049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75035.2.
AP009048 Genomic DNA. Translation: BAA15796.2.
PIRiE64961.
RefSeqiNP_416478.2. NC_000913.3.
WP_001395354.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76340.
SMRiP76340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260386. 5 interactors.
DIPiDIP-11853N.
IntActiP76340. 2 interactors.
MINTiMINT-1223015.
STRINGi511145.b1969.

Proteomic databases

PaxDbiP76340.
PRIDEiP76340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75035; AAC75035; b1969.
BAA15796; BAA15796; BAA15796.
GeneIDi946486.
KEGGiecj:JW5322.
eco:b1969.
PATRICi32119269. VBIEscCol129921_2049.

Organism-specific databases

EchoBASEiEB3798.
EcoGeneiEG14045. yedW.

Phylogenomic databases

eggNOGiENOG4105CK6. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
InParanoidiP76340.
KOiK02483.
OMAiCDVIQTV.
PhylomeDBiP76340.

Enzyme and pathway databases

BioCyciEcoCyc:G7057-MONOMER.
ECOL316407:JW5322-MONOMER.

Miscellaneous databases

PROiP76340.

Family and domain databases

CDDicd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR006291. PcoR.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
TIGRFAMsiTIGR01387. cztR_silR_copR. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEDW_ECOLI
AccessioniPrimary (citable) accession number: P76340
Secondary accession number(s): P97172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.