Probable transcriptional regulatory protein YedW

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P76340 (YEDW_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable transcriptional regulatory protein YedW

Gene names

Name:	yedW
Ordered Locus Names:	b1969, JW5322

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable member of a two-component regulatory system YedW/YedV.
Subcellular location	Cytoplasm Probable.
Post-translational modification	Phosphorylated by YedV. Ref.4
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system
Cellular component	Cytoplasm
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 223

223

Probable transcriptional regulatory protein YedW

PRO_0000081360

Regions

Domain

1 – 115

115

Response regulatory

Amino acid modifications

Modified residue

4-aspartylphosphate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P76340 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 4A595D7430C2E2B5
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FASTA

223

25,018

        10         20         30         40         50         60 
MKILLIEDNQ RTQEWVTQGL SEAGYVIDAV SDGRDGLYLA LKDDYALIIL DIMLPGMDGW 

        70         80         90        100        110        120 
QILQTLRTAK QTPVICLTAR DSVDDRVRGL DSGANDYLVK PFSFSELLAR VRAQLRQHHA 

       130        140        150        160        170        180 
LNSTLEISGL RMDSVSHSVS RDNISITLTR KEFQLLWLLA SRAGEIIPRT VIASEIWGIN 

       190        200        210        220 
FDSDTNTVDV AIRRLRAKVD DPFPEKLIAT IRGMGYSFVA VKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. Horiuchi T. DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli." Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A. J. Biol. Chem. 280:1448-1456(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC75035.2. AP009048 Genomic DNA. Translation: BAA15796.2.
PIR	E64961.
RefSeq	NP_416478.2. NC_000913.2. YP_490219.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P76340.
SMR	P76340. Positions 1-216.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-11853N.
IntAct	P76340. 1 interaction.
MINT	MINT-1223015.
STRING	511145.b1969.
Proteomic databases
PaxDb	P76340.
PRIDE	P76340.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75035; AAC75035; b1969. BAA15796; BAA15796; BAA15796.
GeneID	12931392. 946486.
KEGG	ecj:Y75_p1936. eco:b1969.
PATRIC	32119269. VBIEscCol129921_2049.
Organism-specific databases
EchoBASE	EB3798.
EcoGene	EG14045. yedW.
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034815.
KO	K02483.
OMA	MTYDLWH.
ProtClustDB	PRK11517.
Enzyme and pathway databases
BioCyc	EcoCyc:G7057-MONOMER. ECOL316407:JW5322-MONOMER.
Gene expression databases
Genevestigator	P76340.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR016032. Sig_transdc_resp-reg_C-effctor. IPR006291. Sig_transdc_resp-reg_metal. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF46894. Bipartite_resp_reg_C-effector. 1 hit. SSF52172. CheY_like. 1 hit.
TIGRFAMs	TIGR01387. cztR_silR_copR. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YEDW_ECOLI

Accession

Primary (citable) accession number: P76340
Secondary accession number(s): P97172

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 27, 2001
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents