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Protein

Probable sensor-like histidine kinase YedV

Gene

yedV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable member of a two-component regulatory system YedW/YedV. Activates YedW by phosphorylation.1 Publication

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphorelay sensor kinase activity Source: InterPro
  • protein kinase activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7056-MONOMER.
ECOL316407:JW1951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sensor-like histidine kinase YedV (EC:2.7.13.3)
Gene namesi
Name:yedV
Ordered Locus Names:b1968, JW1951
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14044. yedV.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 158128PeriplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Topological domaini180 – 452273CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Probable sensor-like histidine kinase YedVPRO_0000074914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP76339.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ygbTQ468963EBI-554869,EBI-1130209

Protein-protein interaction databases

BioGridi4259161. 12 interactions.
DIPiDIP-11852N.
IntActiP76339. 4 interactions.
MINTiMINT-1232374.
STRINGi511145.b1968.

Structurei

3D structure databases

ProteinModelPortaliP76339.
SMRiP76339. Positions 188-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 23454HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini242 – 452211Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107ZY3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000126762.
InParanoidiP76339.
KOiK02484.
OMAiKSHIHIT.
PhylomeDBiP76339.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR006290. CztS_silS_copS.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01386. cztS_silS_copS. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLSITVRL TLLFILLLSV AGAGIVWTLY NGLASELKWR DDTTLINRTA
60 70 80 90 100
QIKQLLIDGV NPDTLPVYFN RMMDVSQDIL IIHGDSINKI VNRTNVSDGM
110 120 130 140 150
LNNIPASETI SAAGIYRSII NDTEIDALRI NIDEVSPSLT VTVAKLASAR
160 170 180 190 200
HNMLEQYKIN SIIICIVAIV LCSVLSPLLI RTGLREIKKL SGVTEALNYN
210 220 230 240 250
DSREPVEVSA LPRELKPLGQ ALNKMHHALV KDFERLSQFA DDLAHELRTP
260 270 280 290 300
INALLGQNQV TLSQTRSIAE YQKTIAGNIE ELENISRLTE NILFLARADK
310 320 330 340 350
NNVLVKLDSL SLNKEVENLL DYLEYLSDEK EICFKVECNQ QIFADKILLQ
360 370 380 390 400
RMLSNLIVNA IRYSPEKSRI HITSFLDTNS YLNIDIASPG TKINEPEKLF
410 420 430 440 450
RRFWRGDNSR HSVGQGLGLS LVKAIAELHG GSATYHYLNK HNVFRITLPQ

RN
Length:452
Mass (Da):50,850
Last modified:February 1, 1997 - v1
Checksum:i172A6410C3CEBE8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75034.1.
AP009048 Genomic DNA. Translation: BAA15795.1.
PIRiD64961.
RefSeqiNP_416477.1. NC_000913.3.
WP_000826792.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75034; AAC75034; b1968.
BAA15795; BAA15795; BAA15795.
GeneIDi946487.
KEGGiecj:JW1951.
eco:b1968.
PATRICi32119267. VBIEscCol129921_2048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75034.1.
AP009048 Genomic DNA. Translation: BAA15795.1.
PIRiD64961.
RefSeqiNP_416477.1. NC_000913.3.
WP_000826792.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76339.
SMRiP76339. Positions 188-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259161. 12 interactions.
DIPiDIP-11852N.
IntActiP76339. 4 interactions.
MINTiMINT-1232374.
STRINGi511145.b1968.

Proteomic databases

PaxDbiP76339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75034; AAC75034; b1968.
BAA15795; BAA15795; BAA15795.
GeneIDi946487.
KEGGiecj:JW1951.
eco:b1968.
PATRICi32119267. VBIEscCol129921_2048.

Organism-specific databases

EchoBASEiEB3797.
EcoGeneiEG14044. yedV.

Phylogenomic databases

eggNOGiENOG4107ZY3. Bacteria.
COG0642. LUCA.
HOGENOMiHOG000126762.
InParanoidiP76339.
KOiK02484.
OMAiKSHIHIT.
PhylomeDBiP76339.

Enzyme and pathway databases

BioCyciEcoCyc:G7056-MONOMER.
ECOL316407:JW1951-MONOMER.

Miscellaneous databases

PROiP76339.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR006290. CztS_silS_copS.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01386. cztS_silS_copS. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEDV_ECOLI
AccessioniPrimary (citable) accession number: P76339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.