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Protein

Flagellar biosynthetic protein FlhB

Gene

flhB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7028-MONOMER.
ECOL316407:JW1869-MONOMER.

Protein family/group databases

MEROPSiN06.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthetic protein FlhB
Gene namesi
Name:flhB
Synonyms:yecQ
Ordered Locus Names:b1880, JW1869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14035. flhB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31PeriplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 73CytoplasmicSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 144CytoplasmicSequence analysisAdd BLAST29
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 189PeriplasmicSequence analysisAdd BLAST24
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 382CytoplasmicSequence analysisAdd BLAST172

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001809491 – 382Flagellar biosynthetic protein FlhBAdd BLAST382

Proteomic databases

PaxDbiP76299.
PRIDEiP76299.

Interactioni

Protein-protein interaction databases

BioGridi4260378. 19 interactors.
IntActiP76299. 3 interactors.
STRINGi511145.b1880.

Structurei

3D structure databases

ProteinModelPortaliP76299.
SMRiP76299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type III secretion exporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D00. Bacteria.
COG1377. LUCA.
HOGENOMiHOG000253899.
InParanoidiP76299.
KOiK02401.
OMAiNLKMSKQ.
PhylomeDBiP76299.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006136. FlhB.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR00328. flhB. 1 hit.

Sequencei

Sequence statusi: Complete.

P76299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDESDDKTE APTPHRLEKA REEGQIPRSR ELTSLLILLV GVSVIWFGGV
60 70 80 90 100
SLARRLSGML SAGLHFDHSI INDPNLILGQ IILLIREAML ALLPLISGVV
110 120 130 140 150
LVALISPVML GGLVFSGKSL QPKFSKLNPL PGIKRMFSAQ TGAELLKAIL
160 170 180 190 200
KTILVGSVTG FFLWHHWPQM MRLMAESPIT AMGNAMDLVG LCALLVVLGV
210 220 230 240 250
IPMVGFDVFF QIFSHLKKLR MSRQDIRDEF KQSEGDPHVK GRIRQMQRAA
260 270 280 290 300
ARRRMMADVP KADVIVNNPT HYSVALQYDE NKMSAPKVVA KGAGLVALRI
310 320 330 340 350
REIGAENNVP TLEAPPLARA LYRHAEIGQQ IPGQLYAAVA EVLAWVWQLK
360 370 380
RWRLAGGQRP VQPTHLPVPE ALDFINEKPT HE
Length:382
Mass (Da):42,238
Last modified:February 1, 1997 - v1
Checksum:i3E319DFC30FEC4CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250A → R in AAC17834 (Ref. 1) Curated1
Sequence conflicti316P → R in AAC17834 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA. Translation: AAC17834.1.
U00096 Genomic DNA. Translation: AAC74950.1.
AP009048 Genomic DNA. Translation: BAA15696.1.
PIRiH64950.
RefSeqiNP_416394.1. NC_000913.3.
WP_001278954.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74950; AAC74950; b1880.
BAA15696; BAA15696; BAA15696.
GeneIDi946391.
KEGGiecj:JW1869.
eco:b1880.
PATRICi32119085. VBIEscCol129921_1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA. Translation: AAC17834.1.
U00096 Genomic DNA. Translation: AAC74950.1.
AP009048 Genomic DNA. Translation: BAA15696.1.
PIRiH64950.
RefSeqiNP_416394.1. NC_000913.3.
WP_001278954.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76299.
SMRiP76299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260378. 19 interactors.
IntActiP76299. 3 interactors.
STRINGi511145.b1880.

Protein family/group databases

MEROPSiN06.A01.

Proteomic databases

PaxDbiP76299.
PRIDEiP76299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74950; AAC74950; b1880.
BAA15696; BAA15696; BAA15696.
GeneIDi946391.
KEGGiecj:JW1869.
eco:b1880.
PATRICi32119085. VBIEscCol129921_1960.

Organism-specific databases

EchoBASEiEB3789.
EcoGeneiEG14035. flhB.

Phylogenomic databases

eggNOGiENOG4105D00. Bacteria.
COG1377. LUCA.
HOGENOMiHOG000253899.
InParanoidiP76299.
KOiK02401.
OMAiNLKMSKQ.
PhylomeDBiP76299.

Enzyme and pathway databases

BioCyciEcoCyc:G7028-MONOMER.
ECOL316407:JW1869-MONOMER.

Miscellaneous databases

PROiP76299.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006136. FlhB.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PANTHERiPTHR30531. PTHR30531. 1 hit.
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR00328. flhB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFLHB_ECOLI
AccessioniPrimary (citable) accession number: P76299
Secondary accession number(s): O87955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.