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Protein

Flagellar biosynthetic protein FlhB

Gene

flhB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

Keywordsi

Biological processBacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7028-MONOMER

Protein family/group databases

MEROPSiN06.A01

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthetic protein FlhB
Gene namesi
Name:flhB
Synonyms:yecQ
Ordered Locus Names:b1880, JW1869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14035 flhB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31PeriplasmicSequence analysisAdd BLAST31
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 73CytoplasmicSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 144CytoplasmicSequence analysisAdd BLAST29
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 189PeriplasmicSequence analysisAdd BLAST24
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 382CytoplasmicSequence analysisAdd BLAST172

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001809491 – 382Flagellar biosynthetic protein FlhBAdd BLAST382

Proteomic databases

PaxDbiP76299
PRIDEiP76299

Interactioni

Protein-protein interaction databases

BioGridi4260378, 21 interactors
IntActiP76299, 3 interactors
STRINGi316385.ECDH10B_2021

Structurei

3D structure databases

ProteinModelPortaliP76299
SMRiP76299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type III secretion exporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D00 Bacteria
COG1377 LUCA
HOGENOMiHOG000253899
InParanoidiP76299
KOiK02401
OMAiSLKMTKQ
PhylomeDBiP76299

Family and domain databases

Gene3Di3.40.1690.10, 1 hit
InterProiView protein in InterPro
IPR006136 FlhB
IPR006135 T3SS_substrate_exporter
IPR029025 T3SS_substrate_exporter_C
PANTHERiPTHR30531 PTHR30531, 1 hit
PfamiView protein in Pfam
PF01312 Bac_export_2, 1 hit
PRINTSiPR00950 TYPE3IMSPROT
SUPFAMiSSF160544 SSF160544, 1 hit
TIGRFAMsiTIGR00328 flhB, 1 hit

Sequencei

Sequence statusi: Complete.

P76299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDESDDKTE APTPHRLEKA REEGQIPRSR ELTSLLILLV GVSVIWFGGV
60 70 80 90 100
SLARRLSGML SAGLHFDHSI INDPNLILGQ IILLIREAML ALLPLISGVV
110 120 130 140 150
LVALISPVML GGLVFSGKSL QPKFSKLNPL PGIKRMFSAQ TGAELLKAIL
160 170 180 190 200
KTILVGSVTG FFLWHHWPQM MRLMAESPIT AMGNAMDLVG LCALLVVLGV
210 220 230 240 250
IPMVGFDVFF QIFSHLKKLR MSRQDIRDEF KQSEGDPHVK GRIRQMQRAA
260 270 280 290 300
ARRRMMADVP KADVIVNNPT HYSVALQYDE NKMSAPKVVA KGAGLVALRI
310 320 330 340 350
REIGAENNVP TLEAPPLARA LYRHAEIGQQ IPGQLYAAVA EVLAWVWQLK
360 370 380
RWRLAGGQRP VQPTHLPVPE ALDFINEKPT HE
Length:382
Mass (Da):42,238
Last modified:February 1, 1997 - v1
Checksum:i3E319DFC30FEC4CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250A → R in AAC17834 (Ref. 1) Curated1
Sequence conflicti316P → R in AAC17834 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA Translation: AAC17834.1
U00096 Genomic DNA Translation: AAC74950.1
AP009048 Genomic DNA Translation: BAA15696.1
PIRiH64950
RefSeqiNP_416394.1, NC_000913.3
WP_001278954.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74950; AAC74950; b1880
BAA15696; BAA15696; BAA15696
GeneIDi946391
KEGGiecj:JW1869
eco:b1880
PATRICifig|1411691.4.peg.368

Similar proteinsi

Entry informationi

Entry nameiFLHB_ECOLI
AccessioniPrimary (citable) accession number: P76299
Secondary accession number(s): O87955
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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