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P76299

- FLHB_ECOLI

UniProt

P76299 - FLHB_ECOLI

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Protein

Flagellar biosynthetic protein FlhB

Gene

flhB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

  1. bacterial-type flagellum assembly Source: InterPro
  2. protein secretion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7028-MONOMER.
ECOL316407:JW1869-MONOMER.

Protein family/group databases

MEROPSiN06.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthetic protein FlhB
Gene namesi
Name:flhB
Synonyms:yecQ
Ordered Locus Names:b1880, JW1869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG14035. flhB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Topological domaini53 – 7321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Topological domaini116 – 14429CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 18924PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 382172CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Flagellar biosynthetic protein FlhBPRO_0000180949Add
BLAST

Proteomic databases

PRIDEiP76299.

Expressioni

Gene expression databases

GenevestigatoriP76299.

Interactioni

Protein-protein interaction databases

IntActiP76299. 3 interactions.
STRINGi511145.b1880.

Structurei

3D structure databases

ProteinModelPortaliP76299.
SMRiP76299. Positions 228-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type III secretion exporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1377.
HOGENOMiHOG000253899.
InParanoidiP76299.
KOiK02401.
OMAiETEGKPE.
OrthoDBiEOG6FRD1F.
PhylomeDBiP76299.

Family and domain databases

Gene3Di3.40.1690.10. 1 hit.
InterProiIPR006136. T3SS_FlhB.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view]
PfamiPF01312. Bac_export_2. 1 hit.
[Graphical view]
PRINTSiPR00950. TYPE3IMSPROT.
SUPFAMiSSF160544. SSF160544. 1 hit.
TIGRFAMsiTIGR00328. flhB. 1 hit.

Sequencei

Sequence statusi: Complete.

P76299-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDESDDKTE APTPHRLEKA REEGQIPRSR ELTSLLILLV GVSVIWFGGV
60 70 80 90 100
SLARRLSGML SAGLHFDHSI INDPNLILGQ IILLIREAML ALLPLISGVV
110 120 130 140 150
LVALISPVML GGLVFSGKSL QPKFSKLNPL PGIKRMFSAQ TGAELLKAIL
160 170 180 190 200
KTILVGSVTG FFLWHHWPQM MRLMAESPIT AMGNAMDLVG LCALLVVLGV
210 220 230 240 250
IPMVGFDVFF QIFSHLKKLR MSRQDIRDEF KQSEGDPHVK GRIRQMQRAA
260 270 280 290 300
ARRRMMADVP KADVIVNNPT HYSVALQYDE NKMSAPKVVA KGAGLVALRI
310 320 330 340 350
REIGAENNVP TLEAPPLARA LYRHAEIGQQ IPGQLYAAVA EVLAWVWQLK
360 370 380
RWRLAGGQRP VQPTHLPVPE ALDFINEKPT HE
Length:382
Mass (Da):42,238
Last modified:February 1, 1997 - v1
Checksum:i3E319DFC30FEC4CC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501A → R in AAC17834. 1 PublicationCurated
Sequence conflicti316 – 3161P → R in AAC17834. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA. Translation: AAC17834.1.
U00096 Genomic DNA. Translation: AAC74950.1.
AP009048 Genomic DNA. Translation: BAA15696.1.
PIRiH64950.
RefSeqiNP_416394.1. NC_000913.3.
YP_490142.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74950; AAC74950; b1880.
BAA15696; BAA15696; BAA15696.
GeneIDi12931384.
946391.
KEGGiecj:Y75_p1856.
eco:b1880.
PATRICi32119085. VBIEscCol129921_1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA. Translation: AAC17834.1 .
U00096 Genomic DNA. Translation: AAC74950.1 .
AP009048 Genomic DNA. Translation: BAA15696.1 .
PIRi H64950.
RefSeqi NP_416394.1. NC_000913.3.
YP_490142.1. NC_007779.1.

3D structure databases

ProteinModelPortali P76299.
SMRi P76299. Positions 228-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P76299. 3 interactions.
STRINGi 511145.b1880.

Protein family/group databases

MEROPSi N06.A01.

Proteomic databases

PRIDEi P76299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74950 ; AAC74950 ; b1880 .
BAA15696 ; BAA15696 ; BAA15696 .
GeneIDi 12931384.
946391.
KEGGi ecj:Y75_p1856.
eco:b1880.
PATRICi 32119085. VBIEscCol129921_1960.

Organism-specific databases

EchoBASEi EB3789.
EcoGenei EG14035. flhB.

Phylogenomic databases

eggNOGi COG1377.
HOGENOMi HOG000253899.
InParanoidi P76299.
KOi K02401.
OMAi ETEGKPE.
OrthoDBi EOG6FRD1F.
PhylomeDBi P76299.

Enzyme and pathway databases

BioCyci EcoCyc:G7028-MONOMER.
ECOL316407:JW1869-MONOMER.

Miscellaneous databases

PROi P76299.

Gene expression databases

Genevestigatori P76299.

Family and domain databases

Gene3Di 3.40.1690.10. 1 hit.
InterProi IPR006136. T3SS_FlhB.
IPR006135. T3SS_substrate_exporter.
IPR029025. T3SS_substrate_exporter_C.
[Graphical view ]
Pfami PF01312. Bac_export_2. 1 hit.
[Graphical view ]
PRINTSi PR00950. TYPE3IMSPROT.
SUPFAMi SSF160544. SSF160544. 1 hit.
TIGRFAMsi TIGR00328. flhB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization of flhB operon in E.coli."
    Cho M., Matsumura P.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiFLHB_ECOLI
AccessioniPrimary (citable) accession number: P76299
Secondary accession number(s): O87955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3