Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P76299

- FLHB_ECOLI

UniProt

P76299 - FLHB_ECOLI

Protein

Flagellar biosynthetic protein FlhB

Gene

flhB

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

    GO - Biological processi

    1. protein secretion Source: InterPro

    Keywords - Biological processi

    Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciEcoCyc:G7028-MONOMER.
    ECOL316407:JW1869-MONOMER.

    Protein family/group databases

    MEROPSiN06.A01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellar biosynthetic protein FlhB
    Gene namesi
    Name:flhB
    Synonyms:yecQ
    Ordered Locus Names:b1880, JW1869
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG14035. flhB.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Flagellar biosynthetic protein FlhBPRO_0000180949Add
    BLAST

    Proteomic databases

    PRIDEiP76299.

    Expressioni

    Gene expression databases

    GenevestigatoriP76299.

    Interactioni

    Protein-protein interaction databases

    IntActiP76299. 3 interactions.
    STRINGi511145.b1880.

    Structurei

    3D structure databases

    ProteinModelPortaliP76299.
    SMRiP76299. Positions 228-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 7321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 14429CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 18924PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini211 – 382172CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type III secretion exporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1377.
    HOGENOMiHOG000253899.
    KOiK02401.
    OMAiETEGKPE.
    OrthoDBiEOG6FRD1F.
    PhylomeDBiP76299.

    Family and domain databases

    Gene3Di3.40.1690.10. 1 hit.
    InterProiIPR006136. T3SS_FlhB.
    IPR006135. T3SS_substrate_exporter.
    IPR029025. T3SS_substrate_exporter_C.
    [Graphical view]
    PfamiPF01312. Bac_export_2. 1 hit.
    [Graphical view]
    PRINTSiPR00950. TYPE3IMSPROT.
    SUPFAMiSSF160544. SSF160544. 1 hit.
    TIGRFAMsiTIGR00328. flhB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P76299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDESDDKTE APTPHRLEKA REEGQIPRSR ELTSLLILLV GVSVIWFGGV    50
    SLARRLSGML SAGLHFDHSI INDPNLILGQ IILLIREAML ALLPLISGVV 100
    LVALISPVML GGLVFSGKSL QPKFSKLNPL PGIKRMFSAQ TGAELLKAIL 150
    KTILVGSVTG FFLWHHWPQM MRLMAESPIT AMGNAMDLVG LCALLVVLGV 200
    IPMVGFDVFF QIFSHLKKLR MSRQDIRDEF KQSEGDPHVK GRIRQMQRAA 250
    ARRRMMADVP KADVIVNNPT HYSVALQYDE NKMSAPKVVA KGAGLVALRI 300
    REIGAENNVP TLEAPPLARA LYRHAEIGQQ IPGQLYAAVA EVLAWVWQLK 350
    RWRLAGGQRP VQPTHLPVPE ALDFINEKPT HE 382
    Length:382
    Mass (Da):42,238
    Last modified:February 1, 1997 - v1
    Checksum:i3E319DFC30FEC4CC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501A → R in AAC17834. 1 PublicationCurated
    Sequence conflicti316 – 3161P → R in AAC17834. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88319 Genomic DNA. Translation: AAC17834.1.
    U00096 Genomic DNA. Translation: AAC74950.1.
    AP009048 Genomic DNA. Translation: BAA15696.1.
    PIRiH64950.
    RefSeqiNP_416394.1. NC_000913.3.
    YP_490142.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74950; AAC74950; b1880.
    BAA15696; BAA15696; BAA15696.
    GeneIDi12931384.
    946391.
    KEGGiecj:Y75_p1856.
    eco:b1880.
    PATRICi32119085. VBIEscCol129921_1960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88319 Genomic DNA. Translation: AAC17834.1 .
    U00096 Genomic DNA. Translation: AAC74950.1 .
    AP009048 Genomic DNA. Translation: BAA15696.1 .
    PIRi H64950.
    RefSeqi NP_416394.1. NC_000913.3.
    YP_490142.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P76299.
    SMRi P76299. Positions 228-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P76299. 3 interactions.
    STRINGi 511145.b1880.

    Protein family/group databases

    MEROPSi N06.A01.

    Proteomic databases

    PRIDEi P76299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74950 ; AAC74950 ; b1880 .
    BAA15696 ; BAA15696 ; BAA15696 .
    GeneIDi 12931384.
    946391.
    KEGGi ecj:Y75_p1856.
    eco:b1880.
    PATRICi 32119085. VBIEscCol129921_1960.

    Organism-specific databases

    EchoBASEi EB3789.
    EcoGenei EG14035. flhB.

    Phylogenomic databases

    eggNOGi COG1377.
    HOGENOMi HOG000253899.
    KOi K02401.
    OMAi ETEGKPE.
    OrthoDBi EOG6FRD1F.
    PhylomeDBi P76299.

    Enzyme and pathway databases

    BioCyci EcoCyc:G7028-MONOMER.
    ECOL316407:JW1869-MONOMER.

    Miscellaneous databases

    PROi P76299.

    Gene expression databases

    Genevestigatori P76299.

    Family and domain databases

    Gene3Di 3.40.1690.10. 1 hit.
    InterProi IPR006136. T3SS_FlhB.
    IPR006135. T3SS_substrate_exporter.
    IPR029025. T3SS_substrate_exporter_C.
    [Graphical view ]
    Pfami PF01312. Bac_export_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00950. TYPE3IMSPROT.
    SUPFAMi SSF160544. SSF160544. 1 hit.
    TIGRFAMsi TIGR00328. flhB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of flhB operon in E.coli."
      Cho M., Matsumura P.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Global topology analysis of the Escherichia coli inner membrane proteome."
      Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
      Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiFLHB_ECOLI
    AccessioniPrimary (citable) accession number: P76299
    Secondary accession number(s): O87955
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3