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Protein

Flagellar biosynthesis protein FlhA

Gene

flhA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

GO - Biological processi

  • bacterial-type flagellum assembly Source: EcoCyc
  • protein secretion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Bacterial flagellum biogenesis, Bacterial flagellum protein export, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G370-MONOMER.
ECOL316407:JW1868-MONOMER.

Protein family/group databases

TCDBi1.A.104.1.1. the proposed flagellar biosynthesis na+ channel, flah (flah) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar biosynthesis protein FlhA
Gene namesi
Name:flhA
Ordered Locus Names:b1879, JW1868
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14273. flhA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900161 – 692Flagellar biosynthesis protein FlhAAdd BLAST692

Proteomic databases

EPDiP76298.
PaxDbiP76298.
PRIDEiP76298.

Interactioni

Protein-protein interaction databases

BioGridi4260377. 7 interactors.
IntActiP76298. 1 interactor.
STRINGi511145.b1879.

Structurei

3D structure databases

ProteinModelPortaliP76298.
SMRiP76298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254014.
InParanoidiP76298.
KOiK02400.
OMAiETKELGW.
PhylomeDBiP76298.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLAAMLRL PANLKSTQWQ ILAGPILILL ILSMMVLPLP AFILDLLFTF
60 70 80 90 100
NIALSIMVLL VAMFTQRTLE FAAFPTILLF TTLLRLALNV ASTRIILMEG
110 120 130 140 150
HTGAAAAGKV VEAFGHFLVG GNFAIGIVVF VILVIINFMV ITKGAGRIAE
160 170 180 190 200
VGARFVLDGM PGKQMAIDAD LNAGLIGEDE AKKRRSEVTQ EADFYGSMDG
210 220 230 240 250
ASKFVRGDAI AGILIMVINI VGGLLVGVLQ HGMSMGHAAE SYTLLTIGDG
260 270 280 290 300
LVAQIPALVI STAAGVIVTR VSTDQDVGEQ MVNQLFSNPS VMLLSAAVLG
310 320 330 340 350
LLGLVPGMPN LVFLLFTAGL LGLAWWIRGR EQKAPAEPKP VKMAENNTVV
360 370 380 390 400
EATWNDVQLE DSLGMEVGYR LIPMVDFQQD GELLGRIRSI RKKFAQEMGF
410 420 430 440 450
LPPVVHIRDN MDLQPARYRI LMKGVEIGSG DAYPGRWLAI NPGTAAGTLP
460 470 480 490 500
GEATVDPAFG LNAIWIESAL KEQAQIQGYT VVEASTVVAT HLNHLISQHA
510 520 530 540 550
AELFGRQEAQ QLLDRVAQEM PKLTEDLVPG VVTLTTLHKV LQNLLDEKVP
560 570 580 590 600
IRDMRTILET LAEHAPIQSD PHELTAVVRV ALGRAITQQW FPGKDEVHVI
610 620 630 640 650
GLDTPLERLL LQALQGGGGL EPGLADRLLA QTQEALSRQE MLGAPPVLLV
660 670 680 690
NHALRPLLSR FLRRSLPQLV VLSNLELSDN RHIRMTATIG GK
Length:692
Mass (Da):74,843
Last modified:February 1, 1997 - v1
Checksum:i558B235085DE69C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328R → S in AAC17835 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA. Translation: AAC17835.1.
U00096 Genomic DNA. Translation: AAC74949.1.
AP009048 Genomic DNA. Translation: BAA15688.1.
PIRiG64950.
RefSeqiNP_416393.1. NC_000913.3.
WP_000066951.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74949; AAC74949; b1879.
BAA15688; BAA15688; BAA15688.
GeneIDi946390.
KEGGiecj:JW1868.
eco:b1879.
PATRICi32119083. VBIEscCol129921_1959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88319 Genomic DNA. Translation: AAC17835.1.
U00096 Genomic DNA. Translation: AAC74949.1.
AP009048 Genomic DNA. Translation: BAA15688.1.
PIRiG64950.
RefSeqiNP_416393.1. NC_000913.3.
WP_000066951.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76298.
SMRiP76298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260377. 7 interactors.
IntActiP76298. 1 interactor.
STRINGi511145.b1879.

Protein family/group databases

TCDBi1.A.104.1.1. the proposed flagellar biosynthesis na+ channel, flah (flah) family.

Proteomic databases

EPDiP76298.
PaxDbiP76298.
PRIDEiP76298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74949; AAC74949; b1879.
BAA15688; BAA15688; BAA15688.
GeneIDi946390.
KEGGiecj:JW1868.
eco:b1879.
PATRICi32119083. VBIEscCol129921_1959.

Organism-specific databases

EchoBASEiEB4021.
EcoGeneiEG14273. flhA.

Phylogenomic databases

eggNOGiENOG4105D7B. Bacteria.
COG1298. LUCA.
HOGENOMiHOG000254014.
InParanoidiP76298.
KOiK02400.
OMAiETKELGW.
PhylomeDBiP76298.

Enzyme and pathway databases

BioCyciEcoCyc:G370-MONOMER.
ECOL316407:JW1868-MONOMER.

Miscellaneous databases

PROiP76298.

Family and domain databases

InterProiIPR025505. FHIPEP_CS.
IPR006301. FlhA.
IPR001712. T3SS_FHIPEP.
[Graphical view]
PfamiPF00771. FHIPEP. 1 hit.
[Graphical view]
PIRSFiPIRSF005419. FlhA. 1 hit.
PRINTSiPR00949. TYPE3IMAPROT.
TIGRFAMsiTIGR01398. FlhA. 1 hit.
PROSITEiPS00994. FHIPEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLHA_ECOLI
AccessioniPrimary (citable) accession number: P76298
Secondary accession number(s): O87956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.