P76290 (CMOA_ECOLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 82.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: tRNA (cmo5U34)-methyltransferase EC=2.1.1.- | ||||||
| Gene names |
| ||||||
| Organism | Escherichia coli (strain K12) | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 247 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) By similarity. HAMAP MF_01589 |
| Subunit structure | Monomer By similarity. HAMAP MF_01589 |
| Sequence similarities | Belongs to the methyltransferase superfamily. CmoA family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | tRNA processing |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | tRNA wobble uridine modification Inferred from electronic annotation. Source: InterPro |
| Molecular function | tRNA (uracil) methyltransferase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 247 | 247 | tRNA (cmo5U34)-methyltransferase HAMAP MF_01589 | PRO_0000169083 | |||||
Regions | |||||||||
| Region | 64 – 66 | 3 | S-adenosyl-L-methionine binding By similarity | ||||||
| Region | 117 – 118 | 2 | S-adenosyl-L-methionine binding By similarity | ||||||
Sites | |||||||||
| Binding site | 39 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 89 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 132 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 199 | 1 | Substrate Potential | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U00096 Genomic DNA. Translation: AAC74940.1. AP009048 Genomic DNA. Translation: BAA15680.1. |
| PIR | F64949. |
| RefSeq | NP_416384.1. NC_000913.2. |
3D structure databases | |
| ProteinModelPortal | P76290. |
| SMR | P76290. Positions 20-242. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P76290. 5 interactions. |
PTM databases | |
| PhosSite | P76290. |
2D gel databases | |
| SWISS-2DPAGE | P76290. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000003301; EBESCP00000003301; EBESCG00000002705. EBESCT00000018270; EBESCP00000017561; EBESCG00000017324. |
| GeneID | 946380. |
| GenomeReviews | Gene locus JW1859 in contig AP009048_GR. Gene locus b1870 in contig U00096_GR. |
| KEGG | ecj:JW1859. eco:b1870. |
| PATRIC | 32119063. VBIEscCol129921_1949. |
Organism-specific databases | |
| EchoBASE | EB3787. |
| EcoGene | EG14033. cmoA. |
Phylogenomic databases | |
| eggNOG | COG0500. |
| GeneTree | EBGT00050000010755. |
| HOGENOM | HBG296860. |
| OMA | YDLGCSR. |
| PhylomeDB | P76290. |
| ProtClustDB | PRK15451. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:G7020-MONOMER. |
Gene expression databases | |
| Genevestigator | P76290. |
Family and domain databases | |
| HAMAP | MF_01589. tRNA_methyltr_CmoA. [Tree] |
| InterPro | IPR005271. tRNA_cmo5U34_MeTrfase. [Graphical view] |
| KO | K15256. |
| PANTHER | PTHR10108:SF412. PTHR10108:SF412. 1 hit. |
| PIRSF | PIRSF006325. MeTrfase_bac. 1 hit. |
| TIGRFAMs | TIGR00740. TIGR00740. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | CMOA_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P76290 Secondary accession number(s): O07982 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

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