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Protein

Free methionine-R-sulfoxide reductase

Gene

msrC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.1 Publication

Catalytic activityi

L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin.1 Publication

Kineticsi

  1. KM=3.9 mM for L-methionine-(R)-S-oxide1 Publication
  2. KM=9.8 µM for thioredoxin1 Publication

    GO - Molecular functioni

    • L-methionine-(R)-S-oxide reductase activity Source: EcoCyc

    Keywordsi

    Molecular functionOxidoreductase

    Enzyme and pathway databases

    BioCyciEcoCyc:G7005-MONOMER
    MetaCyc:G7005-MONOMER
    BRENDAi1.8.4.14 2026

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Free methionine-R-sulfoxide reductase (EC:1.8.4.14)
    Short name:
    fRMsr
    Gene namesi
    Name:msrC
    Synonyms:yebR
    Ordered Locus Names:b1832, JW1821
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    Proteomesi
    • UP000000318 Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    EcoGeneiEG14020 msrC

    Subcellular locationi

    GO - Cellular componenti

    • cytosol Source: EcoCyc

    Pathology & Biotechi

    Chemistry databases

    DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001715531 – 165Free methionine-R-sulfoxide reductaseAdd BLAST165

    Proteomic databases

    PaxDbiP76270
    PRIDEiP76270

    2D gel databases

    SWISS-2DPAGEiP76270

    Interactioni

    Protein-protein interaction databases

    BioGridi425915623 interactors.
    DIPiDIP-11813N
    IntActiP76270 8 interactors.
    STRINGi316385.ECDH10B_1971

    Structurei

    Secondary structure

    1165
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi3 – 18Combined sources16
    Helixi24 – 38Combined sources15
    Beta strandi39 – 41Combined sources3
    Beta strandi43 – 51Combined sources9
    Beta strandi54 – 63Combined sources10
    Beta strandi67 – 70Combined sources4
    Helixi74 – 82Combined sources9
    Beta strandi86 – 89Combined sources4
    Turni91 – 93Combined sources3
    Beta strandi105 – 114Combined sources10
    Beta strandi117 – 128Combined sources12
    Helixi134 – 152Combined sources19
    Helixi156 – 158Combined sources3

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1VHMX-ray2.10A/B1-165[»]
    ProteinModelPortaliP76270
    SMRiP76270
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP76270

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini49 – 149GAFAdd BLAST101

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiENOG4108ZGC Bacteria
    COG1956 LUCA
    HOGENOMiHOG000022909
    InParanoidiP76270
    KOiK08968
    OMAiGICGQVA
    PhylomeDBiP76270

    Family and domain databases

    Gene3Di3.30.450.401 hit
    InterProiView protein in InterPro
    IPR000614 FRMsr_CS
    IPR003018 GAF
    IPR029016 GAF-like_dom_sf
    PfamiView protein in Pfam
    PF13185 GAF_2, 1 hit
    SMARTiView protein in SMART
    SM00065 GAF, 1 hit
    PROSITEiView protein in PROSITE
    PS01320 UPF0067, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P76270-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNKTEFYADL NRDFNALMAG ETSFLATLAN TSALLYERLT DINWAGFYLL
    60 70 80 90 100
    EDDTLVLGPF QGKIACVRIP VGRGVCGTAV ARNQVQRIED VHVFDGHIAC
    110 120 130 140 150
    DAASNSEIVL PLVVKNQIIG VLDIDSTVFG RFTDEDEQGL RQLVAQLEKV
    160
    LATTDYKKFF ASVAG
    Length:165
    Mass (Da):18,122
    Last modified:December 4, 2007 - v2
    Checksum:iB49F1D1740DD5D43
    GO

    Sequence cautioni

    The sequence BAA15640 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U00096 Genomic DNA Translation: AAC74902.2
    AP009048 Genomic DNA Translation: BAA15640.1 Different initiation.
    PIRiH64944
    RefSeqiNP_416346.4, NC_000913.3
    WP_001043877.1, NZ_LN832404.1

    Genome annotation databases

    EnsemblBacteriaiAAC74902; AAC74902; b1832
    BAA15640; BAA15640; BAA15640
    GeneIDi946086
    KEGGiecj:JW1821
    eco:b1832
    PATRICifig|511145.12.peg.1910

    Similar proteinsi

    Entry informationi

    Entry nameiMSRC_ECOLI
    AccessioniPrimary (citable) accession number: P76270
    Secondary accession number(s): O07976, O07978
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 4, 2007
    Last modified: March 28, 2018
    This is version 124 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome