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Protein

Transcriptional regulator KdgR

Gene

kdgR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 5320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7003-MONOMER.
ECOL316407:JW1816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator KdgR
Gene namesi
Name:kdgR
Synonyms:yebP
Ordered Locus Names:b1827, JW1816
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14018. kdgR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Transcriptional regulator KdgRPRO_0000201760Add
BLAST

Proteomic databases

EPDiP76268.
PaxDbiP76268.
PRIDEiP76268.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
yebVP645033EBI-1123676,EBI-9126792

Protein-protein interaction databases

BioGridi4261734. 9 interactions.
DIPiDIP-10057N.
IntActiP76268. 4 interactions.
STRINGi511145.b1827.

Structurei

Secondary structure

1
263
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi88 – 10417Combined sources
Beta strandi108 – 1147Combined sources
Beta strandi117 – 1248Combined sources
Beta strandi139 – 1457Combined sources
Helixi146 – 1538Combined sources
Helixi157 – 1648Combined sources
Helixi180 – 19314Combined sources
Beta strandi196 – 2038Combined sources
Beta strandi206 – 2149Combined sources
Beta strandi220 – 2267Combined sources
Beta strandi229 – 2324Combined sources
Helixi235 – 25521Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YSPX-ray1.80A88-263[»]
ProteinModelPortaliP76268.
SMRiP76268. Positions 31-258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76268.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 7462HTH iclR-typePROSITE-ProRule annotationAdd
BLAST
Domaini89 – 258170IclR-EDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH iclR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 iclR-ED (iclR effector binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105J4Q. Bacteria.
COG1414. LUCA.
HOGENOMiHOG000107041.
InParanoidiP76268.
KOiK19333.
OMAiWRDREEV.
OrthoDBiEOG6MWN8D.
PhylomeDBiP76268.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR014757. Tscrpt_reg_IclR_C.
IPR005471. Tscrpt_reg_IclR_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09339. HTH_IclR. 1 hit.
PF01614. IclR. 1 hit.
[Graphical view]
SMARTiSM00346. HTH_ICLR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS51077. HTH_ICLR. 1 hit.
PS51078. ICLR_ED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANADLDKQP DSVSSVLKVF GILQALGEER EIGITELSQR VMMSKSTVYR
60 70 80 90 100
FLQTMKTLGY VAQEGESEKY SLTLKLFELG ARALQNVDLI RSADIQMREL
110 120 130 140 150
SRLTKETIHL GALDEDSIVY IHKIDSMYNL RMYSRIGRRN PLYSTAIGKV
160 170 180 190 200
LLAWRDRDEV KQILEGVEYK RSTERTITST EALLPVLDQV REQGYGEDNE
210 220 230 240 250
EQEEGLRCIA VPVFDRFGVV IAGLSISFPT LRFSEERLQE YVAMLHTAAR
260
KISAQMGYHD YPF
Length:263
Mass (Da):30,029
Last modified:February 1, 1997 - v1
Checksum:i5744F66467922C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74897.1.
AP009048 Genomic DNA. Translation: BAA15635.1.
PIRiC64944.
RefSeqiNP_416341.1. NC_000913.3.
WP_001262203.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74897; AAC74897; b1827.
BAA15635; BAA15635; BAA15635.
GeneIDi946129.
KEGGiecj:JW1816.
eco:b1827.
PATRICi32118975. VBIEscCol129921_1905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74897.1.
AP009048 Genomic DNA. Translation: BAA15635.1.
PIRiC64944.
RefSeqiNP_416341.1. NC_000913.3.
WP_001262203.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YSPX-ray1.80A88-263[»]
ProteinModelPortaliP76268.
SMRiP76268. Positions 31-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261734. 9 interactions.
DIPiDIP-10057N.
IntActiP76268. 4 interactions.
STRINGi511145.b1827.

Proteomic databases

EPDiP76268.
PaxDbiP76268.
PRIDEiP76268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74897; AAC74897; b1827.
BAA15635; BAA15635; BAA15635.
GeneIDi946129.
KEGGiecj:JW1816.
eco:b1827.
PATRICi32118975. VBIEscCol129921_1905.

Organism-specific databases

EchoBASEiEB3772.
EcoGeneiEG14018. kdgR.

Phylogenomic databases

eggNOGiENOG4105J4Q. Bacteria.
COG1414. LUCA.
HOGENOMiHOG000107041.
InParanoidiP76268.
KOiK19333.
OMAiWRDREEV.
OrthoDBiEOG6MWN8D.
PhylomeDBiP76268.

Enzyme and pathway databases

BioCyciEcoCyc:G7003-MONOMER.
ECOL316407:JW1816-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP76268.
PROiP76268.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.40. 1 hit.
InterProiIPR029016. GAF_dom-like.
IPR014757. Tscrpt_reg_IclR_C.
IPR005471. Tscrpt_reg_IclR_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09339. HTH_IclR. 1 hit.
PF01614. IclR. 1 hit.
[Graphical view]
SMARTiSM00346. HTH_ICLR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS51077. HTH_ICLR. 1 hit.
PS51078. ICLR_ED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Structural study of effector binding specificity in iclR transcriptional regulators."
    Midwest center for structural genomics (MCSG)
    Submitted (MAR-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 88-263.

Entry informationi

Entry nameiKDGR_ECOLI
AccessioniPrimary (citable) accession number: P76268
Secondary accession number(s): O07975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 16, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.