UniProtKB - P76264 (MNTP_ECOLI)
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Protein
Probable manganese efflux pump MntP
Gene
mntP
Organism
Escherichia coli (strain K12)
Status
Functioni
Probably functions as a manganese efflux pump.UniRule annotation1 Publication
GO - Molecular functioni
- manganese ion transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- manganese ion transmembrane transport Source: EcoCyc
- response to manganese ion Source: EcoCyc
Keywordsi
Biological process | Ion transport, Transport |
Ligand | Manganese |
Enzyme and pathway databases
BioCyci | EcoCyc:G6999-MONOMER. MetaCyc:G6999-MONOMER. |
Protein family/group databases
TCDBi | 2.A.107.1.1. the mntp mn(2+) exporter (mntp) family. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable manganese efflux pump MntPUniRule annotation |
Gene namesi | Ordered Locus Names:b1821, JW5830 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Organism-specific databases
EcoGenei | EG14012. mntP. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 2 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 3 – 23 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 24 – 65 | PeriplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 66 – 86 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 87 – 105 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 106 – 128 | HelicalUniRule annotationAdd BLAST | 23 | |
Topological domaini | 129 – 142 | PeriplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 143 – 163 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 164 – 167 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 168 – 187 | HelicalUniRule annotationAdd BLAST | 20 | |
Topological domaini | 188 | PeriplasmicSequence analysis | 1 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Deletion causes manganese sensitivity and leads to increased intracellular manganese levels.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155649 | 1 – 188 | Probable manganese efflux pump MntPAdd BLAST | 188 |
Proteomic databases
PaxDbi | P76264. |
PRIDEi | P76264. |
Expressioni
Inductioni
Up-regulated by MntR in response to manganese.1 Publication
Interactioni
Protein-protein interaction databases
BioGridi | 4263026. 7 interactors. |
STRINGi | 316385.ECDH10B_1959. |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4108UI1. Bacteria. COG1971. LUCA. |
HOGENOMi | HOG000238852. |
InParanoidi | P76264. |
OMAi | HWIAFTL. |
PhylomeDBi | P76264. |
Family and domain databases
HAMAPi | MF_01521. MntP_pump. 1 hit. |
InterProi | View protein in InterPro IPR003810. Mntp/YtaF. IPR022929. Put_MntP. |
PANTHERi | PTHR35529. PTHR35529. 1 hit. |
Pfami | View protein in Pfam PF02659. Mntp. 1 hit. |
i Sequence
Sequence statusi: Complete.
P76264-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNITATVLLA FGMSMDAFAA SIGKGATLHK PKFSEALRTG LIFGAVETLT
60 70 80 90 100
PLIGWGMGML ASRFVLEWNH WIAFVLLIFL GGRMIIEGFR GADDEDEEPR
110 120 130 140 150
RRHGFWLLVT TAIATSLDAM AVGVGLAFLQ VNIIATALAI GCATLIMSTL
160 170 180
GMMVGRFIGS IIGKKAEILG GLVLIGIGVQ ILWTHFHG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA. Translation: AAC74891.2. AP009048 Genomic DNA. Translation: BAA15632.2. X75948 Genomic DNA. No translation available. |
PIRi | E64943. |
RefSeqi | NP_416335.4. NC_000913.3. WP_001296134.1. NZ_LN832404.1. |
Genome annotation databases
EnsemblBacteriai | AAC74891; AAC74891; b1821. BAA15632; BAA15632; BAA15632. |
GeneIDi | 946341. |
KEGGi | ecj:JW5830. eco:b1821. |
PATRICi | fig|511145.12.peg.1898. |
Similar proteinsi
Entry informationi
Entry namei | MNTP_ECOLI | |
Accessioni | P76264Primary (citable) accession number: P76264 Secondary accession number(s): O07974 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | September 27, 2004 | |
Last modified: | March 28, 2018 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |