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Protein

Probable manganese efflux pump MntP

Gene

mntP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as a manganese efflux pump.UniRule annotation1 Publication

GO - Molecular functioni

  • manganese ion transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • manganese ion transmembrane transport Source: EcoCyc
  • response to manganese ion Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciEcoCyc:G6999-MONOMER.
ECOL316407:JW5830-MONOMER.
MetaCyc:G6999-MONOMER.

Protein family/group databases

TCDBi2.A.107.1.1. the mntp mn2+ exporter (mntp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese efflux pump MntPUniRule annotation
Gene namesi
Name:mntPUniRule annotation
Synonyms:yebN
Ordered Locus Names:b1821, JW5830
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14012. mntP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence analysis
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Topological domaini24 – 6542PeriplasmicSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalUniRule annotationAdd
BLAST
Topological domaini87 – 10519CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12823HelicalUniRule annotationAdd
BLAST
Topological domaini129 – 14214PeriplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Topological domaini164 – 1674CytoplasmicSequence analysis
Transmembranei168 – 18720HelicalUniRule annotationAdd
BLAST
Topological domaini188 – 1881PeriplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion causes manganese sensitivity and leads to increased intracellular manganese levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Probable manganese efflux pump MntPPRO_0000155649Add
BLAST

Proteomic databases

PaxDbiP76264.

Expressioni

Inductioni

Up-regulated by MntR in response to manganese.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263026. 7 interactions.
STRINGi511145.b1821.

Structurei

3D structure databases

ProteinModelPortaliP76264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MntP (TC 9.B.29) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108UI1. Bacteria.
COG1971. LUCA.
HOGENOMiHOG000238852.
InParanoidiP76264.
OMAiFIGGKMI.
PhylomeDBiP76264.

Family and domain databases

HAMAPiMF_01521. MntP_pump. 1 hit.
InterProiIPR003810. Mntp/YtaF.
IPR022929. Put_MntP.
[Graphical view]
PfamiPF02659. Mntp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITATVLLA FGMSMDAFAA SIGKGATLHK PKFSEALRTG LIFGAVETLT
60 70 80 90 100
PLIGWGMGML ASRFVLEWNH WIAFVLLIFL GGRMIIEGFR GADDEDEEPR
110 120 130 140 150
RRHGFWLLVT TAIATSLDAM AVGVGLAFLQ VNIIATALAI GCATLIMSTL
160 170 180
GMMVGRFIGS IIGKKAEILG GLVLIGIGVQ ILWTHFHG
Length:188
Mass (Da):20,117
Last modified:September 27, 2004 - v2
Checksum:i09BBB5C3D6185A9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74891.2.
AP009048 Genomic DNA. Translation: BAA15632.2.
X75948 Genomic DNA. No translation available.
PIRiE64943.
RefSeqiNP_416335.4. NC_000913.3.
WP_001296134.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74891; AAC74891; b1821.
BAA15632; BAA15632; BAA15632.
GeneIDi946341.
KEGGiecj:JW5830.
eco:b1821.
PATRICi32118961. VBIEscCol129921_1898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74891.2.
AP009048 Genomic DNA. Translation: BAA15632.2.
X75948 Genomic DNA. No translation available.
PIRiE64943.
RefSeqiNP_416335.4. NC_000913.3.
WP_001296134.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263026. 7 interactions.
STRINGi511145.b1821.

Protein family/group databases

TCDBi2.A.107.1.1. the mntp mn2+ exporter (mntp) family.

Proteomic databases

PaxDbiP76264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74891; AAC74891; b1821.
BAA15632; BAA15632; BAA15632.
GeneIDi946341.
KEGGiecj:JW5830.
eco:b1821.
PATRICi32118961. VBIEscCol129921_1898.

Organism-specific databases

EchoBASEiEB3768.
EcoGeneiEG14012. mntP.

Phylogenomic databases

eggNOGiENOG4108UI1. Bacteria.
COG1971. LUCA.
HOGENOMiHOG000238852.
InParanoidiP76264.
OMAiFIGGKMI.
PhylomeDBiP76264.

Enzyme and pathway databases

BioCyciEcoCyc:G6999-MONOMER.
ECOL316407:JW5830-MONOMER.
MetaCyc:G6999-MONOMER.

Miscellaneous databases

PROiP76264.

Family and domain databases

HAMAPiMF_01521. MntP_pump. 1 hit.
InterProiIPR003810. Mntp/YtaF.
IPR022929. Put_MntP.
[Graphical view]
PfamiPF02659. Mntp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNTP_ECOLI
AccessioniPrimary (citable) accession number: P76264
Secondary accession number(s): O07974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 27, 2004
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.