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Protein

Probable ATP-dependent helicase YoaA

Gene

yoaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 528ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6992-MONOMER.
ECOL316407:JW1797-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent helicase YoaA (EC:3.6.4.12)
Gene namesi
Name:yoaA
Ordered Locus Names:b1808, JW1797
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13513. yoaA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Probable ATP-dependent helicase YoaAPRO_0000102006Add
BLAST

Proteomic databases

EPDiP76257.
PaxDbiP76257.
PRIDEiP76257.

Interactioni

Protein-protein interaction databases

BioGridi4260341. 111 interactions.
DIPiDIP-12786N.
IntActiP76257. 9 interactions.
STRINGi511145.b1808.

Structurei

3D structure databases

ProteinModelPortaliP76257.
SMRiP76257. Positions 39-80, 479-601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 272263Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi225 – 2284DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 1964Poly-Val

Sequence similaritiesi

Belongs to the helicase family. DinG subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DVT. Bacteria.
COG1199. LUCA.
HOGENOMiHOG000242574.
InParanoidiP76257.
KOiK03722.
OMAiAKIIVVN.
OrthoDBiEOG6742WF.
PhylomeDBiP76257.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13307. Helicase_C_2. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDFAPDGQ LAKAIPGFKP REPQRQMAVA VTQAIEKGQP LVVEAGTGTG
60 70 80 90 100
KTYAYLAPAL RAKKKVIIST GSKALQDQLY SRDLPTVSKA LKYTGNVALL
110 120 130 140 150
KGRSNYLCLE RLEQQALAGG DLPVQILSDV ILLRSWSNQT VDGDISTCVS
160 170 180 190 200
VAEDSQAWPL VTSTNDNCLG SDCPMYKDCF VVKARKKAMD ADVVVVNHHL
210 220 230 240 250
FLADMVVKES GFGELIPEAD VMIFDEAHQL PDIASQYFGQ SLSSRQLLDL
260 270 280 290 300
AKDITIAYRT ELKDTQQLQK CADRLAQSAQ DFRLQLGEPG YRGNLRELLA
310 320 330 340 350
NPQIQRAFLL LDDTLELCYD VAKLSLGRSA LLDAAFERAT LYRTRLKRLK
360 370 380 390 400
EINQPGYSYW YECTSRHFTL ALTPLSVADK FKELMAQKPG SWIFTSATLS
410 420 430 440 450
VNDDLHHFTS RLGIEQAESL LLPSPFDYSR QALLCVLRNL PQTNQPGSAR
460 470 480 490 500
QLAAMLRPII EANNGRCFML CTSHAMMRDL AEQFRATMTL PVLLQGETSK
510 520 530 540 550
GQLLQQFVSA GNALLVATSS FWEGVDVRGD TLSLVIIDKL PFTSPDDPLL
560 570 580 590 600
KARMEDCRLR GGDPFDEVQL PDAVITLKQG VGRLIRDADD RGVLVICDNR
610 620 630
LVMRPYGATF LASLPPAPRT RDIARAVRFL AIPSSR
Length:636
Mass (Da):70,378
Last modified:February 1, 1997 - v1
Checksum:i14CEBD04CCBE701F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74878.1.
AP009048 Genomic DNA. Translation: BAA15617.1.
PIRiH64941.
RefSeqiNP_416322.1. NC_000913.3.
WP_000128841.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74878; AAC74878; b1808.
BAA15617; BAA15617; BAA15617.
GeneIDi946305.
KEGGiecj:JW1797.
eco:b1808.
PATRICi32118933. VBIEscCol129921_1884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74878.1.
AP009048 Genomic DNA. Translation: BAA15617.1.
PIRiH64941.
RefSeqiNP_416322.1. NC_000913.3.
WP_000128841.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76257.
SMRiP76257. Positions 39-80, 479-601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260341. 111 interactions.
DIPiDIP-12786N.
IntActiP76257. 9 interactions.
STRINGi511145.b1808.

Proteomic databases

EPDiP76257.
PaxDbiP76257.
PRIDEiP76257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74878; AAC74878; b1808.
BAA15617; BAA15617; BAA15617.
GeneIDi946305.
KEGGiecj:JW1797.
eco:b1808.
PATRICi32118933. VBIEscCol129921_1884.

Organism-specific databases

EchoBASEiEB3286.
EcoGeneiEG13513. yoaA.

Phylogenomic databases

eggNOGiENOG4105DVT. Bacteria.
COG1199. LUCA.
HOGENOMiHOG000242574.
InParanoidiP76257.
KOiK03722.
OMAiAKIIVVN.
OrthoDBiEOG6742WF.
PhylomeDBiP76257.

Enzyme and pathway databases

BioCyciEcoCyc:G6992-MONOMER.
ECOL316407:JW1797-MONOMER.

Miscellaneous databases

PROiP76257.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13307. Helicase_C_2. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYOAA_ECOLI
AccessioniPrimary (citable) accession number: P76257
Secondary accession number(s): O07973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 13, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.