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Protein

HTH-type transcriptional regulator DmlR

Gene

dmlR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 41H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • malate metabolic process Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6985-MONOMER.
ECOL316407:JW1788-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator DmlR
Alternative name(s):
D-malate degradation protein R
Gene namesi
Name:dmlR
Synonyms:yeaT
Ordered Locus Names:b1799, JW1788
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13506. dmlR.

Pathology & Biotechi

Disruption phenotypei

Deletion of dmlR inhibits aerobic growth on D-malate and inhibits the induction of dmlA expression by D-malate and L- and meso-tartrate.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057861 – 307HTH-type transcriptional regulator DmlRAdd BLAST307

Proteomic databases

PaxDbiP76250.
PRIDEiP76250.

Expressioni

Inductioni

Expression of dmlR is subject to negative autoregulation under both aerobic and anaerobic growth conditions. Its level of expression is generally lower under anaerobic conditions than that under aerobic conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260334. 12 interactors.
IntActiP76250. 13 interactors.
STRINGi511145.b1799.

Structurei

3D structure databases

ProteinModelPortaliP76250.
SMRiP76250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 62HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EJC. Bacteria.
ENOG410XNQA. LUCA.
HOGENOMiHOG000233519.
InParanoidiP76250.
KOiK16135.
OMAiQLEIRFD.
PhylomeDBiP76250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLPLLNDL RVFMLVARRA GFAAVAEELG VSPAFVSKRI ALLEQTLNVV
60 70 80 90 100
LLHRTTRRVT ITEEGERIYE WAQRILQDVG QMMDELSDVR QVPQGMLRII
110 120 130 140 150
SSFGFGRQVV APALLALAKA YPQLELRFDV EDRLVDLVNE GVDLDIRIGD
160 170 180 190 200
DIAPNLIARK LATNYRILCA SPEFIAQHGA PKHLTDLSAL PCLVIKERDH
210 220 230 240 250
PFGVWQLRNK EGPHAIKVTG PLSSNHGEIV HQWCLDGQGI ALRSWWDVSE
260 270 280 290 300
NIASGHLVQV LPEYYQPANV WAVYVSRLAT SAKVRITVEF LRQYFAEHYP

NFSLEHA
Length:307
Mass (Da):34,631
Last modified:December 15, 1998 - v2
Checksum:i608ACFB1873AA364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74869.2.
AP009048 Genomic DNA. Translation: BAA15594.1.
PIRiG64940.
RefSeqiNP_416313.4. NC_000913.3.
WP_001061575.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74869; AAC74869; b1799.
BAA15594; BAA15594; BAA15594.
GeneIDi946316.
KEGGiecj:JW1788.
eco:b1799.
PATRICi32118915. VBIEscCol129921_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74869.2.
AP009048 Genomic DNA. Translation: BAA15594.1.
PIRiG64940.
RefSeqiNP_416313.4. NC_000913.3.
WP_001061575.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76250.
SMRiP76250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260334. 12 interactors.
IntActiP76250. 13 interactors.
STRINGi511145.b1799.

Proteomic databases

PaxDbiP76250.
PRIDEiP76250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74869; AAC74869; b1799.
BAA15594; BAA15594; BAA15594.
GeneIDi946316.
KEGGiecj:JW1788.
eco:b1799.
PATRICi32118915. VBIEscCol129921_1875.

Organism-specific databases

EchoBASEiEB3279.
EcoGeneiEG13506. dmlR.

Phylogenomic databases

eggNOGiENOG4105EJC. Bacteria.
ENOG410XNQA. LUCA.
HOGENOMiHOG000233519.
InParanoidiP76250.
KOiK16135.
OMAiQLEIRFD.
PhylomeDBiP76250.

Enzyme and pathway databases

BioCyciEcoCyc:G6985-MONOMER.
ECOL316407:JW1788-MONOMER.

Miscellaneous databases

PROiP76250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMLR_ECOLI
AccessioniPrimary (citable) accession number: P76250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.