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Protein

Leucine efflux protein

Gene

leuE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exporter of leucine. Can also transport its natural analog L-alpha-amino-n-butyric acid and some other structurally unrelated amino acids.1 Publication

GO - Molecular functioni

  • homoserine transmembrane transporter activity Source: GO_Central
  • L-leucine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • homoserine transport Source: GO_Central
  • leucine transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6984-MONOMER
MetaCyc:G6984-MONOMER

Protein family/group databases

TCDBi2.A.76.1.5 the resistance to homoserine/threonine (rhtb) family

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine efflux protein
Gene namesi
Name:leuE
Synonyms:yeaS
Ordered Locus Names:b1798, JW1787
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13505 leuE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947421 – 212Leucine efflux proteinAdd BLAST212

Proteomic databases

PaxDbiP76249
PRIDEiP76249

Expressioni

Inductioni

Induced by leucine, L-alpha-amino-n-butyric acid and, to a lesser extent, by several other amino acids. This induction is mediated by lrp.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260333, 34 interactors
STRINGi316385.ECDH10B_1936

Structurei

3D structure databases

ProteinModelPortaliP76249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rht family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108NIW Bacteria
COG1280 LUCA
HOGENOMiHOG000122945
InParanoidiP76249
KOiK11250
OMAiGVGAMFI
PhylomeDBiP76249

Family and domain databases

InterProiView protein in InterPro
IPR001123 LeuE-type
PANTHERiPTHR30086 PTHR30086, 1 hit
PfamiView protein in Pfam
PF01810 LysE, 1 hit
PIRSFiPIRSF006324 LeuE, 1 hit

Sequencei

Sequence statusi: Complete.

P76249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAEYGVLNY WTYLVGAIFI VLVPGPNTLF VLKNSVSSGM KGGYLAACGV
60 70 80 90 100
FIGDAVLMFL AWAGVATLIK TTPILFNIVR YLGAFYLLYL GSKILYATLK
110 120 130 140 150
GKNSEAKSDE PQYGAIFKRA LILSLTNPKA ILFYVSFFVQ FIDVNAPHTG
160 170 180 190 200
ISFFILAATL ELVSFCYLSF LIISGAFVTQ YIRTKKKLAK VGNSLIGLMF
210
VGFAARLATL QS
Length:212
Mass (Da):23,201
Last modified:February 1, 1997 - v1
Checksum:i342E0DF348C9AD9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74868.1
AP009048 Genomic DNA Translation: BAA15593.1
PIRiF64940
RefSeqiNP_416312.1, NC_000913.3
WP_000457206.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74868; AAC74868; b1798
BAA15593; BAA15593; BAA15593
GeneIDi946157
KEGGiecj:JW1787
eco:b1798
PATRICifig|1411691.4.peg.455

Similar proteinsi

Entry informationi

Entry nameiLEUE_ECOLI
AccessioniPrimary (citable) accession number: P76249
Secondary accession number(s): O07969, O07971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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