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P76242 (YEAN_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inner membrane transport protein YeaN
Gene names
Name:yeaN
Ordered Locus Names:b1791, JW1780
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Inner membrane transport protein YeaN
PRO_0000205709

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5219Periplasmic Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 807Cytoplasmic Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane102 – 12221Helical; Potential
Topological domain123 – 14018Cytoplasmic Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 1632Periplasmic Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 21834Cytoplasmic Potential
Transmembrane219 – 23921Helical; Potential
Topological domain240 – 24910Periplasmic Potential
Transmembrane250 – 27021Helical; Potential
Topological domain271 – 2788Cytoplasmic Potential
Transmembrane279 – 29921Helical; Potential
Topological domain300 – 3045Periplasmic Potential
Transmembrane305 – 32521Helical; Potential
Topological domain326 – 3349Cytoplasmic Potential
Transmembrane335 – 35521Helical; Potential
Topological domain356 – 36611Periplasmic Potential
Transmembrane367 – 38721Helical; Potential
Topological domain388 – 3936Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P76242 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: A486E89BA91558B3

FASTA39341,208
        10         20         30         40         50         60 
MTCSTSLSGK NRIVLIAGIL MIATTLRVTF TGAAPLLDTI RSAYSLTTAQ TGLLTTLPLL 

        70         80         90        100        110        120 
AFALISPLAA PVARRFGMER SLFAALLLIC AGIAIRSLPS PYLLFGGTAV IGGGIALGNV 

       130        140        150        160        170        180 
LLPGLIKRDF PHSVARLTGA YSLTMGAAAA LGSAMVVPLA LNGFGWQGAL LMLMCFPLLA 

       190        200        210        220        230        240 
LFLWLPQWRS QQHANLSTSR ALHTRGIWRS PLAWQVTLFL GINSLVYYVI IGWLPAILIS 

       250        260        270        280        290        300 
HGYSEAQAGS LHGLLQLATA APGLLIPLFL HHVKDQRGIA AFVALMCAVG AVGLCFMPAH 

       310        320        330        340        350        360 
AITWTLLFGF GSGATMILGL TFIGLRASSA HQAAALSGMA QSVGYLLAAC GPPLMGKIHD 

       370        380        390 
ANGNWSVPLM GVAILSLLMA IFGLCAGRDK EIR

« Hide

References

[1]"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map."
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. expand/collapse author list , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00096 Genomic DNA. Translation: AAC74861.1.
AP009048 Genomic DNA. Translation: BAA15589.1.
PIRG64939.
RefSeqNP_416305.1. NC_000913.2.
YP_490052.1. NC_007779.1.

3D structure databases

ProteinModelPortalP76242.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b1791.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74861; AAC74861; b1791.
BAA15589; BAA15589; BAA15589.
GeneID12932825.
946309.
KEGGecj:Y75_p1766.
eco:b1791.
PATRIC32118895. VBIEscCol129921_1865.

Organism-specific databases

EchoBASEEB3273.
EcoGeneEG13500. yeaN.

Phylogenomic databases

eggNOGCOG2807.
HOGENOMHOG000273878.
KOK03449.
OMALWIIILG.
ProtClustDBCLSK880204.

Enzyme and pathway databases

BioCycEcoCyc:B1791-MONOMER.
ECOL316407:JW1780-MONOMER.

Gene expression databases

GenevestigatorP76242.

Family and domain databases

InterProIPR004747. Cyan_transport.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00896. CynX. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYEAN_ECOLI
AccessionPrimary (citable) accession number: P76242
Secondary accession number(s): O07966, O07968
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

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