Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-nitroimidazole transporter

Gene

nimT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in efflux of 2-nitroimidazole.1 Publication

GO - Biological processi

  • response to antibiotic Source: EcoCyc
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1791-MONOMER.
ECOL316407:JW1780-MONOMER.
MetaCyc:B1791-MONOMER.

Protein family/group databases

TCDBi2.A.1.17.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
2-nitroimidazole transporter1 Publication
Gene namesi
Name:nimT1 Publication
Synonyms:yeaN
Ordered Locus Names:b1791, JW1780
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13500. nimT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicCuratedAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 52PeriplasmicCuratedAdd BLAST19
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 80CytoplasmicCurated7
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 140CytoplasmicCuratedAdd BLAST18
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 163PeriplasmicCurated2
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 218CytoplasmicCuratedAdd BLAST34
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 249PeriplasmicCurated10
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 278CytoplasmicCurated8
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 304PeriplasmicCurated5
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 334CytoplasmicCurated9
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 366PeriplasmicCuratedAdd BLAST11
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 393Cytoplasmic1 Publication6

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant is sensitive to 2-nitroimidazole.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057091 – 3932-nitroimidazole transporterAdd BLAST393

Proteomic databases

PaxDbiP76242.
PRIDEiP76242.

Expressioni

Inductioni

Repressed by NimR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261819. 164 interactors.
STRINGi511145.b1791.

Structurei

3D structure databases

ProteinModelPortaliP76242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DJ2. Bacteria.
COG2807. LUCA.
HOGENOMiHOG000273878.
InParanoidiP76242.
KOiK03449.
OMAiPLMGRIH.
PhylomeDBiP76242.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004747. Cyan_transport.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00896. CynX. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCSTSLSGK NRIVLIAGIL MIATTLRVTF TGAAPLLDTI RSAYSLTTAQ
60 70 80 90 100
TGLLTTLPLL AFALISPLAA PVARRFGMER SLFAALLLIC AGIAIRSLPS
110 120 130 140 150
PYLLFGGTAV IGGGIALGNV LLPGLIKRDF PHSVARLTGA YSLTMGAAAA
160 170 180 190 200
LGSAMVVPLA LNGFGWQGAL LMLMCFPLLA LFLWLPQWRS QQHANLSTSR
210 220 230 240 250
ALHTRGIWRS PLAWQVTLFL GINSLVYYVI IGWLPAILIS HGYSEAQAGS
260 270 280 290 300
LHGLLQLATA APGLLIPLFL HHVKDQRGIA AFVALMCAVG AVGLCFMPAH
310 320 330 340 350
AITWTLLFGF GSGATMILGL TFIGLRASSA HQAAALSGMA QSVGYLLAAC
360 370 380 390
GPPLMGKIHD ANGNWSVPLM GVAILSLLMA IFGLCAGRDK EIR
Length:393
Mass (Da):41,208
Last modified:February 1, 1997 - v1
Checksum:iA486E89BA91558B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74861.1.
AP009048 Genomic DNA. Translation: BAA15589.1.
PIRiG64939.
RefSeqiNP_416305.1. NC_000913.3.
WP_000128491.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74861; AAC74861; b1791.
BAA15589; BAA15589; BAA15589.
GeneIDi946309.
KEGGiecj:JW1780.
eco:b1791.
PATRICi32118895. VBIEscCol129921_1865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74861.1.
AP009048 Genomic DNA. Translation: BAA15589.1.
PIRiG64939.
RefSeqiNP_416305.1. NC_000913.3.
WP_000128491.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261819. 164 interactors.
STRINGi511145.b1791.

Protein family/group databases

TCDBi2.A.1.17.3. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP76242.
PRIDEiP76242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74861; AAC74861; b1791.
BAA15589; BAA15589; BAA15589.
GeneIDi946309.
KEGGiecj:JW1780.
eco:b1791.
PATRICi32118895. VBIEscCol129921_1865.

Organism-specific databases

EchoBASEiEB3273.
EcoGeneiEG13500. nimT.

Phylogenomic databases

eggNOGiENOG4105DJ2. Bacteria.
COG2807. LUCA.
HOGENOMiHOG000273878.
InParanoidiP76242.
KOiK03449.
OMAiPLMGRIH.
PhylomeDBiP76242.

Enzyme and pathway databases

BioCyciEcoCyc:B1791-MONOMER.
ECOL316407:JW1780-MONOMER.
MetaCyc:B1791-MONOMER.

Miscellaneous databases

PROiP76242.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004747. Cyan_transport.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00896. CynX. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIMT_ECOLI
AccessioniPrimary (citable) accession number: P76242
Secondary accession number(s): O07966, O07968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.