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Protein

2-nitroimidazole transporter

Gene

nimT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in efflux of 2-nitroimidazole.1 Publication

GO - Biological processi

  • response to antibiotic Source: EcoCyc
  • transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1791-MONOMER.
ECOL316407:JW1780-MONOMER.

Protein family/group databases

TCDBi2.A.1.17.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
2-nitroimidazole transporter1 Publication
Gene namesi
Name:nimT1 Publication
Synonyms:yeaN
Ordered Locus Names:b1791, JW1780
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13500. nimT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicCuratedAdd
BLAST
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Topological domaini34 – 5219PeriplasmicCuratedAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Topological domaini74 – 807CytoplasmicCurated
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Topological domaini123 – 14018CytoplasmicCuratedAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 1632PeriplasmicCurated
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 21834CytoplasmicCuratedAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Topological domaini240 – 24910PeriplasmicCurated
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Topological domaini271 – 2788CytoplasmicCurated
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Topological domaini300 – 3045PeriplasmicCurated
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 3349CytoplasmicCurated
Transmembranei335 – 35521HelicalSequence analysisAdd
BLAST
Topological domaini356 – 36611PeriplasmicCuratedAdd
BLAST
Transmembranei367 – 38721HelicalSequence analysisAdd
BLAST
Topological domaini388 – 3936Cytoplasmic1 Publication

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant is sensitive to 2-nitroimidazole.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3933932-nitroimidazole transporterPRO_0000205709Add
BLAST

Proteomic databases

PaxDbiP76242.

Expressioni

Inductioni

Repressed by NimR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261819. 164 interactions.
STRINGi511145.b1791.

Structurei

3D structure databases

ProteinModelPortaliP76242.
SMRiP76242. Positions 51-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DJ2. Bacteria.
COG2807. LUCA.
HOGENOMiHOG000273878.
InParanoidiP76242.
KOiK03449.
OMAiPLMGRIH.
OrthoDBiEOG6BCSTK.
PhylomeDBiP76242.

Family and domain databases

InterProiIPR004747. Cyan_transport.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00896. CynX. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCSTSLSGK NRIVLIAGIL MIATTLRVTF TGAAPLLDTI RSAYSLTTAQ
60 70 80 90 100
TGLLTTLPLL AFALISPLAA PVARRFGMER SLFAALLLIC AGIAIRSLPS
110 120 130 140 150
PYLLFGGTAV IGGGIALGNV LLPGLIKRDF PHSVARLTGA YSLTMGAAAA
160 170 180 190 200
LGSAMVVPLA LNGFGWQGAL LMLMCFPLLA LFLWLPQWRS QQHANLSTSR
210 220 230 240 250
ALHTRGIWRS PLAWQVTLFL GINSLVYYVI IGWLPAILIS HGYSEAQAGS
260 270 280 290 300
LHGLLQLATA APGLLIPLFL HHVKDQRGIA AFVALMCAVG AVGLCFMPAH
310 320 330 340 350
AITWTLLFGF GSGATMILGL TFIGLRASSA HQAAALSGMA QSVGYLLAAC
360 370 380 390
GPPLMGKIHD ANGNWSVPLM GVAILSLLMA IFGLCAGRDK EIR
Length:393
Mass (Da):41,208
Last modified:February 1, 1997 - v1
Checksum:iA486E89BA91558B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74861.1.
AP009048 Genomic DNA. Translation: BAA15589.1.
PIRiG64939.
RefSeqiNP_416305.1. NC_000913.3.
WP_000128491.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74861; AAC74861; b1791.
BAA15589; BAA15589; BAA15589.
GeneIDi946309.
KEGGiecj:JW1780.
eco:b1791.
PATRICi32118895. VBIEscCol129921_1865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74861.1.
AP009048 Genomic DNA. Translation: BAA15589.1.
PIRiG64939.
RefSeqiNP_416305.1. NC_000913.3.
WP_000128491.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76242.
SMRiP76242. Positions 51-83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261819. 164 interactions.
STRINGi511145.b1791.

Protein family/group databases

TCDBi2.A.1.17.3. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP76242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74861; AAC74861; b1791.
BAA15589; BAA15589; BAA15589.
GeneIDi946309.
KEGGiecj:JW1780.
eco:b1791.
PATRICi32118895. VBIEscCol129921_1865.

Organism-specific databases

EchoBASEiEB3273.
EcoGeneiEG13500. nimT.

Phylogenomic databases

eggNOGiENOG4105DJ2. Bacteria.
COG2807. LUCA.
HOGENOMiHOG000273878.
InParanoidiP76242.
KOiK03449.
OMAiPLMGRIH.
OrthoDBiEOG6BCSTK.
PhylomeDBiP76242.

Enzyme and pathway databases

BioCyciEcoCyc:B1791-MONOMER.
ECOL316407:JW1780-MONOMER.

Miscellaneous databases

PROiP76242.

Family and domain databases

InterProiIPR004747. Cyan_transport.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00896. CynX. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Role of transcription factor NimR (YeaM) in sensitivity control of Escherichia coli to 2-nitroimidazole."
    Ogasawara H., Ohe S., Ishihama A.
    FEMS Microbiol. Lett. 362:1-8(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12.

Entry informationi

Entry nameiNIMT_ECOLI
AccessioniPrimary (citable) accession number: P76242
Secondary accession number(s): O07966, O07968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.