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Protein

2-nitroimidazole transporter

Gene

nimT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in efflux of 2-nitroimidazole.1 Publication

GO - Biological processi

  • response to antibiotic Source: EcoCyc
  • transmembrane transport Source: InterPro

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1791-MONOMER
MetaCyc:B1791-MONOMER

Protein family/group databases

TCDBi2.A.1.17.3 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
2-nitroimidazole transporter1 Publication
Gene namesi
Name:nimT1 Publication
Synonyms:yeaN
Ordered Locus Names:b1791, JW1780
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13500 nimT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicCuratedAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 52PeriplasmicCuratedAdd BLAST19
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 80CytoplasmicCurated7
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 140CytoplasmicCuratedAdd BLAST18
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 163PeriplasmicCurated2
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 218CytoplasmicCuratedAdd BLAST34
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 249PeriplasmicCurated10
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 278CytoplasmicCurated8
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 304PeriplasmicCurated5
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 334CytoplasmicCurated9
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 366PeriplasmicCuratedAdd BLAST11
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 393Cytoplasmic1 Publication6

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant is sensitive to 2-nitroimidazole.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057091 – 3932-nitroimidazole transporterAdd BLAST393

Proteomic databases

PaxDbiP76242
PRIDEiP76242

Expressioni

Inductioni

Repressed by NimR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261819, 164 interactors
STRINGi316385.ECDH10B_1929

Structurei

3D structure databases

ProteinModelPortaliP76242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DJ2 Bacteria
COG2807 LUCA
HOGENOMiHOG000273878
InParanoidiP76242
KOiK03449
OMAiYTMALCL
PhylomeDBiP76242

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004747 Cyan_transport
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00896 CynX, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P76242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCSTSLSGK NRIVLIAGIL MIATTLRVTF TGAAPLLDTI RSAYSLTTAQ
60 70 80 90 100
TGLLTTLPLL AFALISPLAA PVARRFGMER SLFAALLLIC AGIAIRSLPS
110 120 130 140 150
PYLLFGGTAV IGGGIALGNV LLPGLIKRDF PHSVARLTGA YSLTMGAAAA
160 170 180 190 200
LGSAMVVPLA LNGFGWQGAL LMLMCFPLLA LFLWLPQWRS QQHANLSTSR
210 220 230 240 250
ALHTRGIWRS PLAWQVTLFL GINSLVYYVI IGWLPAILIS HGYSEAQAGS
260 270 280 290 300
LHGLLQLATA APGLLIPLFL HHVKDQRGIA AFVALMCAVG AVGLCFMPAH
310 320 330 340 350
AITWTLLFGF GSGATMILGL TFIGLRASSA HQAAALSGMA QSVGYLLAAC
360 370 380 390
GPPLMGKIHD ANGNWSVPLM GVAILSLLMA IFGLCAGRDK EIR
Length:393
Mass (Da):41,208
Last modified:February 1, 1997 - v1
Checksum:iA486E89BA91558B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74861.1
AP009048 Genomic DNA Translation: BAA15589.1
PIRiG64939
RefSeqiNP_416305.1, NC_000913.3
WP_000128491.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74861; AAC74861; b1791
BAA15589; BAA15589; BAA15589
GeneIDi946309
KEGGiecj:JW1780
eco:b1791
PATRICifig|1411691.4.peg.464

Similar proteinsi

Entry informationi

Entry nameiNIMT_ECOLI
AccessioniPrimary (citable) accession number: P76242
Secondary accession number(s): O07966, O07968
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health