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Protein

HTH-type transcriptional regulator NimR

Gene

nimR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi178 – 199H-T-H motifPROSITE-ProRule annotationAdd BLAST22
DNA bindingi225 – 248H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6976-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator NimRCurated
Alternative name(s):
Regulator of nimT1 Publication
Gene namesi
Name:nimR1 Publication
Synonyms:yeaM
Ordered Locus Names:b1790, JW1779
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13499 nimR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001946111 – 273HTH-type transcriptional regulator NimRAdd BLAST273

Proteomic databases

PaxDbiP76241
PRIDEiP76241

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260327, 11 interactors
IntActiP76241, 15 interactors
STRINGi316385.ECDH10B_1928

Structurei

3D structure databases

ProteinModelPortaliP76241
SMRiP76241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 258HTH araC/xylS-typePROSITE-ProRule annotationAdd BLAST101

Phylogenomic databases

eggNOGiENOG4105R1U Bacteria
ENOG410XQRW LUCA
HOGENOMiHOG000111166
InParanoidiP76241
OMAiHRHDDHQ
PhylomeDBiP76241

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR003313 AraC-bd
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF02311 AraC_binding, 1 hit
PF12833 HTH_18, 1 hit
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF51182 SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P76241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHRLNLNGY EPDRHHEAAV AFCIHAGTDE LTSPVHQHRK GQLILALHGA
60 70 80 90 100
ITCTVENALW MVPPQYAVWI PGGVEHSNQV TANAELCFLF IEPSAVTMPT
110 120 130 140 150
TCCTLKISPL CRELILTLAN RTTTQRAEPM TRRLIQVLFD ELPQQPQQQL
160 170 180 190 200
HLPVSSHPKI RTMVEMMAKG PVEWGALGQW AGFFAMSERN LARLIVKETG
210 220 230 240 250
LSFRQWRQQL QLIMALQGLV KGDTVQKVAH TLGYDSTTAF ITMFKKGLGQ
260 270
TPGRYIARLT TVSPQSAKPD PRQ
Length:273
Mass (Da):30,554
Last modified:February 1, 1997 - v1
Checksum:i51A7E8E6D5827980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74860.1
AP009048 Genomic DNA Translation: BAE76528.1
PIRiF64939
RefSeqiNP_416304.1, NC_000913.3
WP_000972248.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74860; AAC74860; b1790
BAE76528; BAE76528; BAE76528
GeneIDi946590
KEGGiecj:JW1779
eco:b1790
PATRICifig|511145.12.peg.1864

Similar proteinsi

Entry informationi

Entry nameiNIMR_ECOLI
AccessioniPrimary (citable) accession number: P76241
Secondary accession number(s): Q2MB28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health