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Protein

HTH-type transcriptional regulator NimR

Gene

nimR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi178 – 19922H-T-H motifPROSITE-ProRule annotationAdd
BLAST
DNA bindingi225 – 24824H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6976-MONOMER.
ECOL316407:JW1779-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator NimRCurated
Alternative name(s):
Regulator of nimT1 Publication
Gene namesi
Name:nimR1 Publication
Synonyms:yeaM
Ordered Locus Names:b1790, JW1779
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13499. nimR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273HTH-type transcriptional regulator NimRPRO_0000194611Add
BLAST

Proteomic databases

PaxDbiP76241.
PRIDEiP76241.

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260327. 11 interactions.
IntActiP76241. 15 interactions.
STRINGi511145.b1790.

Structurei

3D structure databases

ProteinModelPortaliP76241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 258101HTH araC/xylS-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105R1U. Bacteria.
ENOG410XQRW. LUCA.
HOGENOMiHOG000111166.
InParanoidiP76241.
OMAiRGQLHIV.
PhylomeDBiP76241.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHRLNLNGY EPDRHHEAAV AFCIHAGTDE LTSPVHQHRK GQLILALHGA
60 70 80 90 100
ITCTVENALW MVPPQYAVWI PGGVEHSNQV TANAELCFLF IEPSAVTMPT
110 120 130 140 150
TCCTLKISPL CRELILTLAN RTTTQRAEPM TRRLIQVLFD ELPQQPQQQL
160 170 180 190 200
HLPVSSHPKI RTMVEMMAKG PVEWGALGQW AGFFAMSERN LARLIVKETG
210 220 230 240 250
LSFRQWRQQL QLIMALQGLV KGDTVQKVAH TLGYDSTTAF ITMFKKGLGQ
260 270
TPGRYIARLT TVSPQSAKPD PRQ
Length:273
Mass (Da):30,554
Last modified:February 1, 1997 - v1
Checksum:i51A7E8E6D5827980
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74860.1.
AP009048 Genomic DNA. Translation: BAE76528.1.
PIRiF64939.
RefSeqiNP_416304.1. NC_000913.3.
WP_000972248.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74860; AAC74860; b1790.
BAE76528; BAE76528; BAE76528.
GeneIDi946590.
KEGGiecj:JW1779.
eco:b1790.
PATRICi32118893. VBIEscCol129921_1864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74860.1.
AP009048 Genomic DNA. Translation: BAE76528.1.
PIRiF64939.
RefSeqiNP_416304.1. NC_000913.3.
WP_000972248.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260327. 11 interactions.
IntActiP76241. 15 interactions.
STRINGi511145.b1790.

Proteomic databases

PaxDbiP76241.
PRIDEiP76241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74860; AAC74860; b1790.
BAE76528; BAE76528; BAE76528.
GeneIDi946590.
KEGGiecj:JW1779.
eco:b1790.
PATRICi32118893. VBIEscCol129921_1864.

Organism-specific databases

EchoBASEiEB3272.
EcoGeneiEG13499. nimR.

Phylogenomic databases

eggNOGiENOG4105R1U. Bacteria.
ENOG410XQRW. LUCA.
HOGENOMiHOG000111166.
InParanoidiP76241.
OMAiRGQLHIV.
PhylomeDBiP76241.

Enzyme and pathway databases

BioCyciEcoCyc:G6976-MONOMER.
ECOL316407:JW1779-MONOMER.

Miscellaneous databases

PROiP76241.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIMR_ECOLI
AccessioniPrimary (citable) accession number: P76241
Secondary accession number(s): Q2MB28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.