Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P76204

- YDIV_ECOLI

UniProt

P76204 - YDIV_ECOLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative anti-FlhC(2)FlhD(4) factor YdiV

Gene

ydiV

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Upon overexpression acts as a novel anti-FlhC2FlhD4 factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC.

GO - Molecular functioni

  1. transcription factor binding Source: EcoCyc

GO - Biological processi

  1. negative regulation of bacterial-type flagellum-dependent cell motility Source: EcoCyc
  2. negative regulation of sequence-specific DNA binding transcription factor activity Source: EcoCyc
  3. negative regulation of transcription regulatory region DNA binding Source: EcoCyc
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6925-MONOMER.
ECOL316407:JW1697-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative anti-FlhC(2)FlhD(4) factor YdiV
Alternative name(s):
c-di-GMP regulator CdgR
Gene namesi
Name:ydiV
Synonyms:cdgR
Ordered Locus Names:b1707, JW1697
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13981. ydiV.

Pathology & Biotechi

Disruption phenotypei

A double sdiA/ydiV deletion mutant leads to decreased cAMP levels which inhibits quorum sensing system 2. Repressed by glucose. Unlike the case in Salmonella typhimurium, disruption has no effect on motility or FliC levels.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Putative anti-FlhC(2)FlhD(4) factor YdiVPRO_0000168997Add
BLAST

Expressioni

Inductioni

Induced by extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6), in an SdiA-dependent fashion. Repressed by glucose. Induced at pH 5.0 in an RpoS-dependent fashion. Very poorly expressed in both rich and nutrient-poor medium due to inefficient translation (at protein level).3 Publications

Gene expression databases

GenevestigatoriP76204.

Interactioni

Protein-protein interaction databases

DIPiDIP-11763N.
IntActiP76204. 5 interactions.
STRINGi511145.b1707.

Structurei

Secondary structure

1
237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 85
Beta strandi9 – 1911
Beta strandi25 – 3612
Beta strandi39 – 435
Helixi45 – 517
Helixi54 – 7017
Helixi72 – 776
Beta strandi81 – 855
Helixi88 – 969
Beta strandi97 – 1015
Helixi102 – 1054
Beta strandi110 – 1145
Helixi121 – 1266
Helixi128 – 1369
Beta strandi139 – 1446
Beta strandi146 – 1494
Helixi152 – 1554
Beta strandi160 – 1645
Helixi166 – 1749
Helixi176 – 1783
Helixi179 – 18911
Turni190 – 1923
Beta strandi194 – 1985
Helixi204 – 2107
Helixi211 – 2133
Beta strandi216 – 2183
Helixi228 – 2347

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TLQX-ray1.91A/B1-237[»]
4ES4X-ray2.90A/C/E/G1-237[»]
ProteinModelPortaliP76204.
SMRiP76204. Positions 2-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 237237EALAdd
BLAST

Sequence similaritiesi

Belongs to the YdiV family.Curated
Contains 1 EAL domain.Curated

Phylogenomic databases

eggNOGiCOG2200.
HOGENOMiHOG000120996.
OMAiSFEPFMR.
OrthoDBiEOG6V4GB5.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR001633. EAL_dom.
[Graphical view]
PfamiPF00563. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.

Sequencei

Sequence statusi: Complete.

P76204 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIFLENLYH SDCYFLPIRD NQQVLVGVEL ITHFSSEDGT VRIPTSRVIA
60 70 80 90 100
QLTEEQHWQL FSEQLELLKS CQHFFIQHKL FAWLNLTPQV ATLLLERDNY
110 120 130 140 150
AGELLKYPFI ELLINENYPH LNEGKDNRGL LSLSQVYPLV LGNLGAGNST
160 170 180 190 200
MKAVFDGLFT RVMLDKSFIQ QQITHRSFEP FIRAIQAQIS PCCNCIIAGG
210 220 230
IDTAEILAQI TPFDFHALQG CLWPAVPINQ ITTLVQR
Length:237
Mass (Da):27,046
Last modified:February 1, 1997 - v1
Checksum:i5684FCD246D7C16F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74777.1.
AP009048 Genomic DNA. Translation: BAE76505.1.
PIRiC64929.
RefSeqiNP_416222.1. NC_000913.3.
YP_489969.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74777; AAC74777; b1707.
BAE76505; BAE76505; BAE76505.
GeneIDi12931305.
946217.
KEGGiecj:Y75_p1682.
eco:b1707.
PATRICi32118720. VBIEscCol129921_1778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74777.1 .
AP009048 Genomic DNA. Translation: BAE76505.1 .
PIRi C64929.
RefSeqi NP_416222.1. NC_000913.3.
YP_489969.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TLQ X-ray 1.91 A/B 1-237 [» ]
4ES4 X-ray 2.90 A/C/E/G 1-237 [» ]
ProteinModelPortali P76204.
SMRi P76204. Positions 2-237.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-11763N.
IntActi P76204. 5 interactions.
STRINGi 511145.b1707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74777 ; AAC74777 ; b1707 .
BAE76505 ; BAE76505 ; BAE76505 .
GeneIDi 12931305.
946217.
KEGGi ecj:Y75_p1682.
eco:b1707.
PATRICi 32118720. VBIEscCol129921_1778.

Organism-specific databases

EchoBASEi EB3738.
EcoGenei EG13981. ydiV.

Phylogenomic databases

eggNOGi COG2200.
HOGENOMi HOG000120996.
OMAi SFEPFMR.
OrthoDBi EOG6V4GB5.

Enzyme and pathway databases

BioCyci EcoCyc:G6925-MONOMER.
ECOL316407:JW1697-MONOMER.

Miscellaneous databases

PROi P76204.

Gene expression databases

Genevestigatori P76204.

Family and domain databases

Gene3Di 3.20.20.450. 1 hit.
InterProi IPR001633. EAL_dom.
[Graphical view ]
Pfami PF00563. EAL. 1 hit.
[Graphical view ]
SUPFAMi SSF141868. SSF141868. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli."
    Weber H., Pesavento C., Possling A., Tischendorf G., Hengge R.
    Mol. Microbiol. 62:1014-1034(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, RPOS-DEPENDENCE.
    Strain: K12 / MC4100.
  4. "An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli."
    Zhou X., Meng X., Sun B.
    Cell Res. 18:937-948(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY AI-1 IN AN SDIA-DEPENDENT FASHION, REPRESSION BY GLUCOSE, DISRUPTION PHENOTYPE.
    Strain: K12 / W3110 / ZK126.
  5. "Functional and expressional analyses of the anti-FlhD4C2 factor gene ydiV in Escherichia coli."
    Wada T., Hatamoto Y., Kutsukake K.
    Microbiology 158:1533-1542(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION, INTERACTION WITH FLHC(2)FLHD(4), INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Entry informationi

Entry nameiYDIV_ECOLI
AccessioniPrimary (citable) accession number: P76204
Secondary accession number(s): Q2MB51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3