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P76204 (YDIV_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative anti-FlhC(2)FlhD(4) factor YdiV
Alternative name(s):
c-di-GMP regulator CdgR
Gene names
Name:ydiV
Synonyms:cdgR
Ordered Locus Names:b1707, JW1697
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Upon overexpression acts as a novel anti-FlhC2FlhD4 factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC. Ref.5

Induction

Induced by extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6), in an SdiA-dependent fashion. Repressed by glucose. Induced at pH 5.0 in an RpoS-dependent fashion. Very poorly expressed in both rich and nutrient-poor medium due to inefficient translation (at protein level). Ref.3 Ref.4 Ref.5

Disruption phenotype

A double sdiA/ydiV deletion mutant leads to decreased cAMP levels which inhibits quorum sensing system 2. Repressed by glucose. Unlike the case in Salmonella typhimurium, disruption has no effect on motility or FliC levels. Ref.4 Ref.5

Sequence similarities

Belongs to the YdiV family.

Contains 1 EAL domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Putative anti-FlhC(2)FlhD(4) factor YdiV
PRO_0000168997

Regions

Domain1 – 237237EAL

Secondary structure

................................................. 237
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P76204 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 5684FCD246D7C16F

FASTA23727,046
        10         20         30         40         50         60 
MKIFLENLYH SDCYFLPIRD NQQVLVGVEL ITHFSSEDGT VRIPTSRVIA QLTEEQHWQL 

        70         80         90        100        110        120 
FSEQLELLKS CQHFFIQHKL FAWLNLTPQV ATLLLERDNY AGELLKYPFI ELLINENYPH 

       130        140        150        160        170        180 
LNEGKDNRGL LSLSQVYPLV LGNLGAGNST MKAVFDGLFT RVMLDKSFIQ QQITHRSFEP 

       190        200        210        220        230 
FIRAIQAQIS PCCNCIIAGG IDTAEILAQI TPFDFHALQG CLWPAVPINQ ITTLVQR 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli."
Weber H., Pesavento C., Possling A., Tischendorf G., Hengge R.
Mol. Microbiol. 62:1014-1034(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, RPOS-DEPENDENCE.
Strain: K12 / MC4100.
[4]"An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli."
Zhou X., Meng X., Sun B.
Cell Res. 18:937-948(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY AI-1 IN AN SDIA-DEPENDENT FASHION, REPRESSION BY GLUCOSE, DISRUPTION PHENOTYPE.
Strain: K12 / W3110 / ZK126.
[5]"Functional and expressional analyses of the anti-FlhD4C2 factor gene ydiV in Escherichia coli."
Wada T., Hatamoto Y., Kutsukake K.
Microbiology 158:1533-1542(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION, INTERACTION WITH FLHC(2)FLHD(4), INDUCTION, DISRUPTION PHENOTYPE.
Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC74777.1.
AP009048 Genomic DNA. Translation: BAE76505.1.
PIRC64929.
RefSeqNP_416222.1. NC_000913.3.
YP_489969.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3TLQX-ray1.91A/B1-237[»]
4ES4X-ray2.90A/C/E/G1-237[»]
ProteinModelPortalP76204.
SMRP76204. Positions 2-237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-11763N.
IntActP76204. 5 interactions.
STRING511145.b1707.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74777; AAC74777; b1707.
BAE76505; BAE76505; BAE76505.
GeneID12931305.
946217.
KEGGecj:Y75_p1682.
eco:b1707.
PATRIC32118720. VBIEscCol129921_1778.

Organism-specific databases

EchoBASEEB3738.
EcoGeneEG13981. ydiV.

Phylogenomic databases

eggNOGCOG2200.
HOGENOMHOG000120996.
OMASFEPFMR.
OrthoDBEOG6V4GB5.
ProtClustDBCLSK880169.

Enzyme and pathway databases

BioCycEcoCyc:G6925-MONOMER.
ECOL316407:JW1697-MONOMER.

Gene expression databases

GenevestigatorP76204.

Family and domain databases

Gene3D3.20.20.450. 1 hit.
InterProIPR001633. Diguanylate_PEstase_EAL_dom.
[Graphical view]
PfamPF00563. EAL. 1 hit.
[Graphical view]
SUPFAMSSF141868. SSF141868. 1 hit.
ProtoNetSearch...

Other

PROP76204.

Entry information

Entry nameYDIV_ECOLI
AccessionPrimary (citable) accession number: P76204
Secondary accession number(s): Q2MB51
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene