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Protein

Voltage-gated ClC-type chloride channel ClcB

Gene

clcB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

BioCyciEcoCyc:YNFJ-MONOMER.
ECOL316407:JW5263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated ClC-type chloride channel ClcB
Gene namesi
Name:clcB
Synonyms:mriT, ynfJ
Ordered Locus Names:b1592, JW5263
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13848. clcB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11CytoplasmicSequence analysis
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Topological domaini23 – 5331PeriplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Topological domaini75 – 14571CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Topological domaini167 – 17711PeriplasmicSequence analysisAdd
BLAST
Transmembranei178 – 20023HelicalSequence analysisAdd
BLAST
Topological domaini201 – 22121CytoplasmicSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 25715PeriplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 29012CytoplasmicSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Topological domaini312 – 3154PeriplasmicSequence analysis
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Topological domaini337 – 35115CytoplasmicSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Topological domaini373 – 3797PeriplasmicSequence analysis
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Topological domaini401 – 41818CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Voltage-gated ClC-type chloride channel ClcBPRO_0000094485Add
BLAST

Proteomic databases

PaxDbiP76175.

Interactioni

Protein-protein interaction databases

BioGridi4259118. 6 interactions.
DIPiDIP-28065N.
IntActiP76175. 1 interaction.
STRINGi511145.b1592.

Structurei

3D structure databases

ProteinModelPortaliP76175.
SMRiP76175. Positions 5-410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CMQ. Bacteria.
COG0038. LUCA.
HOGENOMiHOG000230177.
InParanoidiP76175.
KOiK03281.
OMAiPWYVRFW.
PhylomeDBiP76175.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
HAMAPiMF_01203. CLC_ClcB. 1 hit.
InterProiIPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR023790. Cl-channel_volt-gated_ClcB.
[Graphical view]
PfamiPF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
SUPFAMiSSF81340. SSF81340. 1 hit.

Sequencei

Sequence statusi: Complete.

P76175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHRLLIATV VGILAAFAVA GFRHAMLLLE WLFLNNDSGS LVNAATNLSP
60 70 80 90 100
WRRLLTPALG GLAAGLLLMG WQKFTQQRPH APTDYMEALQ TDGQFDYAAS
110 120 130 140 150
LVKSLASLLV VTSGSAIGRE GAMILLAALA ASCFAQRFTP RQEWKLWIAC
160 170 180 190 200
GAAAGMAAAY RAPLAGSLFI AEVLFGTMML ASLGPVIISA VVALLVSNLI
210 220 230 240 250
NHSDALLYNV QLSVTVQARD YALIISTGVL AGLCGPLLLT LMNACHRGFV
260 270 280 290 300
SLKLAPPWQL ALGGLIVGLL SLFTPAVWGN GYSTVQSFLT APPLLMIIAG
310 320 330 340 350
IFLCKLCAVL ASSGSGAPGG VFTPTLFIGL AIGMLYGRSL GLWFPDGEEI
360 370 380 390 400
TLLLGLTGMA TLLAATTHAP IMSTLMICEM TGEYQLLPGL LIACVIASVI
410
SRTLHRDSIY RQHTAQHS
Length:418
Mass (Da):44,153
Last modified:April 23, 2003 - v2
Checksum:iF19EAFD7C87F4C01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74664.2.
AP009048 Genomic DNA. Translation: BAA15316.2.
PIRiB64915.
RefSeqiNP_416109.2. NC_000913.3.
WP_001350514.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74664; AAC74664; b1592.
BAA15316; BAA15316; BAA15316.
GeneIDi947179.
KEGGiecj:JW5263.
eco:b1592.
PATRICi32118486. VBIEscCol129921_1663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74664.2.
AP009048 Genomic DNA. Translation: BAA15316.2.
PIRiB64915.
RefSeqiNP_416109.2. NC_000913.3.
WP_001350514.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76175.
SMRiP76175. Positions 5-410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259118. 6 interactions.
DIPiDIP-28065N.
IntActiP76175. 1 interaction.
STRINGi511145.b1592.

Proteomic databases

PaxDbiP76175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74664; AAC74664; b1592.
BAA15316; BAA15316; BAA15316.
GeneIDi947179.
KEGGiecj:JW5263.
eco:b1592.
PATRICi32118486. VBIEscCol129921_1663.

Organism-specific databases

EchoBASEiEB3609.
EcoGeneiEG13848. clcB.

Phylogenomic databases

eggNOGiENOG4105CMQ. Bacteria.
COG0038. LUCA.
HOGENOMiHOG000230177.
InParanoidiP76175.
KOiK03281.
OMAiPWYVRFW.
PhylomeDBiP76175.

Enzyme and pathway databases

BioCyciEcoCyc:YNFJ-MONOMER.
ECOL316407:JW5263-MONOMER.

Miscellaneous databases

PROiP76175.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
HAMAPiMF_01203. CLC_ClcB. 1 hit.
InterProiIPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR023790. Cl-channel_volt-gated_ClcB.
[Graphical view]
PfamiPF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
SUPFAMiSSF81340. SSF81340. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLCB_ECOLI
AccessioniPrimary (citable) accession number: P76175
Secondary accession number(s): P77195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: April 23, 2003
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.