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Protein

Anaerobic dimethyl sulfoxide reductase chain YnfH

Gene

ynfH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. The C subunit anchors the other two subunits to the membrane and stabilize the catalytic subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:G6848-MONOMER
MetaCyc:G6848-MONOMER

Protein family/group databases

TCDBi5.A.3.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic dimethyl sulfoxide reductase chain YnfH
Alternative name(s):
DMSO reductase anchor subunit YnfH
Gene namesi
Name:ynfH
Ordered Locus Names:b1590, JW5261
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13846 ynfH

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 45CytoplasmicSequence analysisAdd BLAST15
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 86PeriplasmicSequence analysisAdd BLAST20
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 115CytoplasmicSequence analysis8
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 148PeriplasmicSequence analysisAdd BLAST12
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 180CytoplasmicSequence analysisAdd BLAST11
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 222PeriplasmicSequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 250CytoplasmicSequence analysis7
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 284PeriplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells grow to slightly higher density than wild-type in sublethal levels of streptomycin (PubMed:25316676).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001689671 – 284Anaerobic dimethyl sulfoxide reductase chain YnfHAdd BLAST284

Proteomic databases

PaxDbiP76173
PRIDEiP76173

Interactioni

Subunit structurei

The complex consists of three subunits: YnfF, the reductase; YnfG, an electron transfer protein, and YnfH, a membrane anchor protein.Curated

Protein-protein interaction databases

BioGridi4263479, 7 interactors
STRINGi316385.ECDH10B_1723

Structurei

3D structure databases

ProteinModelPortaliP76173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To E.coli DmsC.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107KGK Bacteria
COG3302 LUCA
HOGENOMiHOG000118381
KOiK07312
OMAiMTRVYQI

Family and domain databases

InterProiView protein in InterPro
IPR007059 DmsC
PANTHERiPTHR38095 PTHR38095, 1 hit
PfamiView protein in Pfam
PF04976 DmsC, 1 hit

Sequencei

Sequence statusi: Complete.

P76173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGWHEWPL VIFTVLGQCV VGALIVSGIG WFAAKNDADR QRIVRGMFFL
60 70 80 90 100
WLLMGVGFIA SVMHLGSPLR AFNSLNRIGA SGLSNEIAAG SIFFAVGGLW
110 120 130 140 150
WLVAVIGKMP QALGKLWLLF SMALGVIFVW MMTCVYQIDT VPTWHNGYTT
160 170 180 190 200
LAFFLTVLLS GPILAAAILR AARVTFNTTP FAIISVLALI ACAGVIVLQG
210 220 230 240 250
LSLASIHSSV QQASALVPDY ASLQVWRVVL LCAGLGCWLC PLIRRREPHV
260 270 280
AGLILGLILI LGGEMIGRVL FYGLHMTVGM AIAG
Length:284
Mass (Da):30,524
Last modified:February 1, 1997 - v1
Checksum:i73F7D760FC4B1344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74662.1
AP009048 Genomic DNA Translation: BAA15314.2
PIRiH64914
RefSeqiNP_416107.1, NC_000913.3
WP_000526503.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74662; AAC74662; b1590
BAA15314; BAA15314; BAA15314
GeneIDi945822
KEGGiecj:JW5261
eco:b1590
PATRICifig|1411691.4.peg.672

Similar proteinsi

Entry informationi

Entry nameiYNFH_ECOLI
AccessioniPrimary (citable) accession number: P76173
Secondary accession number(s): P77142
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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