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Protein

Putative defective protein IntQ

Gene

intQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:G6837-MONOMER.
ECOL316407:JW1571-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative defective protein IntQCurated
Alternative name(s):
Putative lambdoid prophage Qin defective integrase
Gene namesi
Name:intQ
Ordered Locus Names:b1579, JW1571
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13188. intQ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975161 – 398Putative defective protein IntQAdd BLAST398

Proteomic databases

PRIDEiP76168.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
xseAP049942EBI-559711,EBI-559703

Protein-protein interaction databases

BioGridi4260817. 24 interactors.
DIPiDIP-10039N.
IntActiP76168. 6 interactors.
STRINGi316407.85675030.

Structurei

3D structure databases

ProteinModelPortaliP76168.
SMRiP76168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4107R08. Bacteria.
COG0582. LUCA.
HOGENOMiHOG000120142.
InParanoidiP76168.
KOiK14059.
OMAiKQFPSSH.
PhylomeDBiP76168.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR022000. DUF3596.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
[Graphical view]
PfamiPF12167. DUF3596. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

P76168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITDVWKYRG KSTGELRSSV CYAIKTGVFD YAKQFPSSRN LEKFGEARQD
60 70 80 90 100
LTIKELAEKF LALKETEVAK TSLNTYRAVI KNILSIIGEK NLASSINKEK
110 120 130 140 150
LLEVRKELLT GYQIPKSNYI VTQPGRSAVT VNNYMTNLNA VFQFGVDNGY
160 170 180 190 200
LADNPFKGIS PLKESRTIPD PLSREEFIRL IDACRNQQAK NLWCVSVYTG
210 220 230 240 250
VRPGELCALG WEDIDLKNGT MMIRRNLAKD RFTVPKTQAG TNRVIHLIKP
260 270 280 290 300
AIDALRSQMT LTRLSKEHII DVHFREYGRT EKQKCTFVFQ PEVSARVKNY
310 320 330 340 350
GDHFTVDSIR QMWDAAIKRA GLRHRKSYQS RHTYACWSLT AGANPAFIAN
360 370 380 390
QMGHADAQMV FQVYGKWMSE NNNAQVALLN TQLSEFAPTM PHNEAMKN
Length:398
Mass (Da):45,262
Last modified:November 2, 2016 - v3
Checksum:iD9A24416922D80CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274F → L in BAE76475 (PubMed:16738553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE76475.1.
PIRiE64913.

Genome annotation databases

EnsemblBacteriaiBAE76475; BAE76475; BAE76475.
KEGGiecj:JW1571.
PATRICi48662472. VBIEscCol107702_1596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE76475.1.
PIRiE64913.

3D structure databases

ProteinModelPortaliP76168.
SMRiP76168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260817. 24 interactors.
DIPiDIP-10039N.
IntActiP76168. 6 interactors.
STRINGi316407.85675030.

Proteomic databases

PRIDEiP76168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE76475; BAE76475; BAE76475.
KEGGiecj:JW1571.
PATRICi48662472. VBIEscCol107702_1596.

Organism-specific databases

EcoGeneiEG13188. intQ.

Phylogenomic databases

eggNOGiENOG4107R08. Bacteria.
COG0582. LUCA.
HOGENOMiHOG000120142.
InParanoidiP76168.
KOiK14059.
OMAiKQFPSSH.
PhylomeDBiP76168.

Enzyme and pathway databases

BioCyciEcoCyc:G6837-MONOMER.
ECOL316407:JW1571-MONOMER.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR022000. DUF3596.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
[Graphical view]
PfamiPF12167. DUF3596. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINTQ_ECOLI
AccessioniPrimary (citable) accession number: P76168
Secondary accession number(s): Q2MB81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2016
Last modified: November 2, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

May not be functional, the original sequence is interrupted by an IS2 element.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.