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Protein

Probable prophage lysozyme

Gene

rrrQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton donorBy similarity1
Active sitei44NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable prophage lysozymeCurated (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Probable lysozyme from lambdoid prophage Qin
Gene namesi
Name:rrrQ
Synonyms:arrQ, ydfQ
Ordered Locus Names:b1554, JW1546
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13829 rrrQ

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002181101 – 177Probable prophage lysozymeAdd BLAST177

Proteomic databases

PaxDbiP76159
PRIDEiP76159

Interactioni

Protein-protein interaction databases

BioGridi4259501, 5 interactors
IntActiP76159, 2 interactors
STRINGi316385.ECDH10B_1686

Structurei

3D structure databases

ProteinModelPortaliP76159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Phylogenomic databases

eggNOGiCOG3772 LUCA
HOGENOMiHOG000277067
InParanoidiP76159
KOiK01185
OMAiKDCRIRS
PhylomeDBiP76159

Family and domain databases

CDDicd00737 endolysin_autolysin, 1 hit
InterProiView protein in InterPro
IPR033907 Endolysin_autolysin
IPR002196 Glyco_hydro_24
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00959 Phage_lysozyme, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

P76159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT
60 70 80 90 100
ICRGATVVDG KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP
110 120 130 140 150
QKAGIASFCP YNIGPGKCFP STFYKRLNAG DRKGACEAIR WWIKDGGRDC
160 170
RIRSNNCYGQ VIRRDQESAL TCWGIEQ
Length:177
Mass (Da):19,663
Last modified:February 1, 1997 - v1
Checksum:i52DCCA3D315AC888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74627.1
AP009048 Genomic DNA Translation: BAE76469.1
PIRiE64910
RefSeqiNP_416072.1, NC_000913.3
WP_001092971.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554
BAE76469; BAE76469; BAE76469
GeneIDi946100
KEGGiecj:JW1546
eco:b1554
PATRICifig|1411691.4.peg.710

Similar proteinsi

Entry informationi

Entry nameiLYSQ_ECOLI
AccessioniPrimary (citable) accession number: P76159
Secondary accession number(s): Q2MB87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health