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Protein

Probable lysozyme from lambdoid prophage Qin

Gene

arrQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton donorBy similarity
Active sitei44 – 441NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysozyme from lambdoid prophage Qin (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:arrQ
Synonyms:ydfQ
Ordered Locus Names:b1554, JW1546
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13829. arrQ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Probable lysozyme from lambdoid prophage QinPRO_0000218110Add
BLAST

Proteomic databases

PRIDEiP76159.

Interactioni

Protein-protein interaction databases

IntActiP76159. 2 interactions.
STRINGi511145.b1554.

Structurei

3D structure databases

ProteinModelPortaliP76159.
SMRiP76159. Positions 32-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Phylogenomic databases

eggNOGiCOG3772.
HOGENOMiHOG000277067.
InParanoidiP76159.
KOiK01185.
OMAiKDCRIRS.
OrthoDBiEOG6M6JNK.
PhylomeDBiP76159.

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P76159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT
60 70 80 90 100
ICRGATVVDG KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP
110 120 130 140 150
QKAGIASFCP YNIGPGKCFP STFYKRLNAG DRKGACEAIR WWIKDGGRDC
160 170
RIRSNNCYGQ VIRRDQESAL TCWGIEQ
Length:177
Mass (Da):19,663
Last modified:February 1, 1997 - v1
Checksum:i52DCCA3D315AC888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRiE64910.
RefSeqiNP_416072.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneIDi946100.
KEGGiecj:Y75_p1530.
eco:b1554.
PATRICi32118410. VBIEscCol129921_1625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRiE64910.
RefSeqiNP_416072.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP76159.
SMRiP76159. Positions 32-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP76159. 2 interactions.
STRINGi511145.b1554.

Proteomic databases

PRIDEiP76159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneIDi946100.
KEGGiecj:Y75_p1530.
eco:b1554.
PATRICi32118410. VBIEscCol129921_1625.

Organism-specific databases

EchoBASEiEB3590.
EcoGeneiEG13829. arrQ.

Phylogenomic databases

eggNOGiCOG3772.
HOGENOMiHOG000277067.
InParanoidiP76159.
KOiK01185.
OMAiKDCRIRS.
OrthoDBiEOG6M6JNK.
PhylomeDBiP76159.

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Miscellaneous databases

PROiP76159.

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiLYSQ_ECOLI
AccessioniPrimary (citable) accession number: P76159
Secondary accession number(s): Q2MB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.