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P76159

- LYSQ_ECOLI

UniProt

P76159 - LYSQ_ECOLI

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Protein
Probable lysozyme from lambdoid prophage Qin
Gene
arrQ, ydfQ, b1554, JW1546
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton donor By similarity
Active sitei44 – 441Nucleophile By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysozyme from lambdoid prophage Qin (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:arrQ
Synonyms:ydfQ
Ordered Locus Names:b1554, JW1546
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13829. arrQ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Probable lysozyme from lambdoid prophage Qin
PRO_0000218110Add
BLAST

Proteomic databases

PRIDEiP76159.

Expressioni

Gene expression databases

GenevestigatoriP76159.

Interactioni

Protein-protein interaction databases

IntActiP76159. 2 interactions.
STRINGi511145.b1554.

Structurei

3D structure databases

ProteinModelPortaliP76159.
SMRiP76159. Positions 32-174.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3772.
HOGENOMiHOG000277067.
KOiK01185.
OMAiKDCRIRS.
OrthoDBiEOG6M6JNK.
PhylomeDBiP76159.

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P76159-1 [UniParc]FASTAAdd to Basket

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MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT    50
ICRGATVVDG KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP 100
QKAGIASFCP YNIGPGKCFP STFYKRLNAG DRKGACEAIR WWIKDGGRDC 150
RIRSNNCYGQ VIRRDQESAL TCWGIEQ 177
Length:177
Mass (Da):19,663
Last modified:February 1, 1997 - v1
Checksum:i52DCCA3D315AC888
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRiE64910.
RefSeqiNP_416072.1. NC_000913.3.
YP_489818.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneIDi12930507.
946100.
KEGGiecj:Y75_p1530.
eco:b1554.
PATRICi32118410. VBIEscCol129921_1625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1 .
AP009048 Genomic DNA. Translation: BAE76469.1 .
PIRi E64910.
RefSeqi NP_416072.1. NC_000913.3.
YP_489818.1. NC_007779.1.

3D structure databases

ProteinModelPortali P76159.
SMRi P76159. Positions 32-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P76159. 2 interactions.
STRINGi 511145.b1554.

Proteomic databases

PRIDEi P76159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74627 ; AAC74627 ; b1554 .
BAE76469 ; BAE76469 ; BAE76469 .
GeneIDi 12930507.
946100.
KEGGi ecj:Y75_p1530.
eco:b1554.
PATRICi 32118410. VBIEscCol129921_1625.

Organism-specific databases

EchoBASEi EB3590.
EcoGenei EG13829. arrQ.

Phylogenomic databases

eggNOGi COG3772.
HOGENOMi HOG000277067.
KOi K01185.
OMAi KDCRIRS.
OrthoDBi EOG6M6JNK.
PhylomeDBi P76159.

Enzyme and pathway databases

BioCyci EcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Miscellaneous databases

PROi P76159.

Gene expression databases

Genevestigatori P76159.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiLYSQ_ECOLI
AccessioniPrimary (citable) accession number: P76159
Secondary accession number(s): Q2MB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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