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P76159

- LYSQ_ECOLI

UniProt

P76159 - LYSQ_ECOLI

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Protein

Probable lysozyme from lambdoid prophage Qin

Gene

arrQ

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton donorBy similarity
Active sitei44 – 441NucleophileBy similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysozyme from lambdoid prophage Qin (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene namesi
Name:arrQ
Synonyms:ydfQ
Ordered Locus Names:b1554, JW1546
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13829. arrQ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Probable lysozyme from lambdoid prophage QinPRO_0000218110Add
BLAST

Proteomic databases

PRIDEiP76159.

Expressioni

Gene expression databases

GenevestigatoriP76159.

Interactioni

Protein-protein interaction databases

IntActiP76159. 2 interactions.
STRINGi511145.b1554.

Structurei

3D structure databases

ProteinModelPortaliP76159.
SMRiP76159. Positions 32-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Phylogenomic databases

eggNOGiCOG3772.
HOGENOMiHOG000277067.
InParanoidiP76159.
KOiK01185.
OMAiKDCRIRS.
OrthoDBiEOG6M6JNK.
PhylomeDBiP76159.

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P76159-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT
60 70 80 90 100
ICRGATVVDG KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP
110 120 130 140 150
QKAGIASFCP YNIGPGKCFP STFYKRLNAG DRKGACEAIR WWIKDGGRDC
160 170
RIRSNNCYGQ VIRRDQESAL TCWGIEQ
Length:177
Mass (Da):19,663
Last modified:February 1, 1997 - v1
Checksum:i52DCCA3D315AC888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRiE64910.
RefSeqiNP_416072.1. NC_000913.3.
YP_489818.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneIDi12930507.
946100.
KEGGiecj:Y75_p1530.
eco:b1554.
PATRICi32118410. VBIEscCol129921_1625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1 .
AP009048 Genomic DNA. Translation: BAE76469.1 .
PIRi E64910.
RefSeqi NP_416072.1. NC_000913.3.
YP_489818.1. NC_007779.1.

3D structure databases

ProteinModelPortali P76159.
SMRi P76159. Positions 32-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P76159. 2 interactions.
STRINGi 511145.b1554.

Proteomic databases

PRIDEi P76159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74627 ; AAC74627 ; b1554 .
BAE76469 ; BAE76469 ; BAE76469 .
GeneIDi 12930507.
946100.
KEGGi ecj:Y75_p1530.
eco:b1554.
PATRICi 32118410. VBIEscCol129921_1625.

Organism-specific databases

EchoBASEi EB3590.
EcoGenei EG13829. arrQ.

Phylogenomic databases

eggNOGi COG3772.
HOGENOMi HOG000277067.
InParanoidi P76159.
KOi K01185.
OMAi KDCRIRS.
OrthoDBi EOG6M6JNK.
PhylomeDBi P76159.

Enzyme and pathway databases

BioCyci EcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Miscellaneous databases

PROi P76159.

Gene expression databases

Genevestigatori P76159.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiLYSQ_ECOLI
AccessioniPrimary (citable) accession number: P76159
Secondary accession number(s): Q2MB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3