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Protein

Probable prophage lysozyme

Gene

rrrQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton donorBy similarity1
Active sitei44NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable prophage lysozymeCurated (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Probable lysozyme from lambdoid prophage Qin
Gene namesi
Name:rrrQ
Synonyms:arrQ, ydfQ
Ordered Locus Names:b1554, JW1546
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13829. rrrQ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002181101 – 177Probable prophage lysozymeAdd BLAST177

Proteomic databases

PaxDbiP76159.
PRIDEiP76159.

Interactioni

Protein-protein interaction databases

BioGridi4259501. 5 interactors.
IntActiP76159. 2 interactors.
STRINGi511145.b1554.

Structurei

3D structure databases

ProteinModelPortaliP76159.
SMRiP76159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Phylogenomic databases

eggNOGiCOG3772. LUCA.
HOGENOMiHOG000277067.
InParanoidiP76159.
KOiK01185.
OMAiKDCRIRS.
PhylomeDBiP76159.

Family and domain databases

CDDicd00737. endolysin_autolysin. 1 hit.
Gene3Di1.10.530.40. 1 hit.
InterProiIPR033907. Endolysin_autolysin.
IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

P76159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT
60 70 80 90 100
ICRGATVVDG KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP
110 120 130 140 150
QKAGIASFCP YNIGPGKCFP STFYKRLNAG DRKGACEAIR WWIKDGGRDC
160 170
RIRSNNCYGQ VIRRDQESAL TCWGIEQ
Length:177
Mass (Da):19,663
Last modified:February 1, 1997 - v1
Checksum:i52DCCA3D315AC888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRiE64910.
RefSeqiNP_416072.1. NC_000913.3.
WP_001092971.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneIDi946100.
KEGGiecj:JW1546.
eco:b1554.
PATRICi32118410. VBIEscCol129921_1625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRiE64910.
RefSeqiNP_416072.1. NC_000913.3.
WP_001092971.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76159.
SMRiP76159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259501. 5 interactors.
IntActiP76159. 2 interactors.
STRINGi511145.b1554.

Proteomic databases

PaxDbiP76159.
PRIDEiP76159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneIDi946100.
KEGGiecj:JW1546.
eco:b1554.
PATRICi32118410. VBIEscCol129921_1625.

Organism-specific databases

EchoBASEiEB3590.
EcoGeneiEG13829. rrrQ.

Phylogenomic databases

eggNOGiCOG3772. LUCA.
HOGENOMiHOG000277067.
InParanoidiP76159.
KOiK01185.
OMAiKDCRIRS.
PhylomeDBiP76159.

Enzyme and pathway databases

BioCyciEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Miscellaneous databases

PROiP76159.

Family and domain databases

CDDicd00737. endolysin_autolysin. 1 hit.
Gene3Di1.10.530.40. 1 hit.
InterProiIPR033907. Endolysin_autolysin.
IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLYSQ_ECOLI
AccessioniPrimary (citable) accession number: P76159
Secondary accession number(s): Q2MB87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.