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P76159 (LYSQ_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable lysozyme from lambdoid prophage Qin

EC=3.2.1.17
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Gene names
Name:arrQ
Synonyms:ydfQ
Ordered Locus Names:b1554, JW1546
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Probable lysozyme from lambdoid prophage Qin
PRO_0000218110

Sites

Active site351Proton donor By similarity
Active site441Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P76159 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 52DCCA3D315AC888

FASTA17719,663
        10         20         30         40         50         60 
MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT ICRGATVVDG 

        70         80         90        100        110        120 
KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP QKAGIASFCP YNIGPGKCFP 

       130        140        150        160        170 
STFYKRLNAG DRKGACEAIR WWIKDGGRDC RIRSNNCYGQ VIRRDQESAL TCWGIEQ 

« Hide

References

[1]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC74627.1.
AP009048 Genomic DNA. Translation: BAE76469.1.
PIRE64910.
RefSeqNP_416072.1. NC_000913.3.
YP_489818.1. NC_007779.1.

3D structure databases

ProteinModelPortalP76159.
SMRP76159. Positions 1-176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP76159. 2 interactions.
STRING511145.b1554.

Proteomic databases

PRIDEP76159.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74627; AAC74627; b1554.
BAE76469; BAE76469; BAE76469.
GeneID12930507.
946100.
KEGGecj:Y75_p1530.
eco:b1554.
PATRIC32118410. VBIEscCol129921_1625.

Organism-specific databases

EchoBASEEB3590.
EcoGeneEG13829. arrQ.

Phylogenomic databases

eggNOGCOG3772.
HOGENOMHOG000277067.
KOK01185.
OMAQESELTC.
OrthoDBEOG6M6JNK.
PhylomeDBP76159.
ProtClustDBCLSK879915.

Enzyme and pathway databases

BioCycEcoCyc:G6827-MONOMER.
ECOL316407:JW1546-MONOMER.

Gene expression databases

GenevestigatorP76159.

Family and domain databases

Gene3D1.10.530.40. 1 hit.
InterProIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Other

PROP76159.

Entry information

Entry nameLYSQ_ECOLI
AccessionPrimary (citable) accession number: P76159
Secondary accession number(s): Q2MB87
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene