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P76141

- LSRR_ECOLI

UniProt

P76141 - LSRR_ECOLI

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Protein

Transcriptional regulator LsrR

Gene
lsrR, ydeW, b1512, JW1505
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motif Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator LsrR
Gene namesi
Name:lsrR
Synonyms:ydeW
Ordered Locus Names:b1512, JW1505
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13805. lsrR.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Transcriptional regulator LsrRPRO_0000062790Add
BLAST

Proteomic databases

PaxDbiP76141.
PRIDEiP76141.

Expressioni

Inductioni

Autoregulated.

Gene expression databases

GenevestigatoriP76141.

Interactioni

Protein-protein interaction databases

DIPiDIP-11688N.
IntActiP76141. 5 interactions.
STRINGi511145.b1512.

Structurei

Secondary structure

1
317
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 2713
Helixi35 – 406
Helixi44 – 5714
Beta strandi58 – 647
Helixi71 – 8111
Beta strandi85 – 906
Helixi98 – 11316
Beta strandi119 – 1224
Helixi126 – 14116
Beta strandi145 – 1517
Helixi154 – 1563
Helixi157 – 1604
Beta strandi161 – 1633
Beta strandi165 – 1673
Helixi181 – 1899
Helixi191 – 20111
Beta strandi204 – 2085
Helixi213 – 2186
Helixi220 – 2234
Helixi229 – 2379
Beta strandi242 – 2443
Beta strandi247 – 2493
Helixi261 – 2644
Helixi270 – 2734
Beta strandi276 – 2827
Helixi286 – 2883
Helixi289 – 2979
Beta strandi302 – 3076
Helixi308 – 3158

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GO1X-ray3.00A/B1-317[»]
4L4YX-ray1.90A/B53-317[»]
4L4ZX-ray2.30A/B53-317[»]
4L50X-ray2.10A/B53-317[»]
4L51X-ray1.90A/B53-317[»]
4L5IX-ray3.21A/B/C/D1-317[»]
4L5JX-ray2.60A/B/C/D1-317[»]
ProteinModelPortaliP76141.
SMRiP76141. Positions 10-317.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2390.
HOGENOMiHOG000243107.
KOiK11531.
OMAiADMQIHQ.
OrthoDBiEOG6GTZKW.
PhylomeDBiP76141.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04198. Sugar-bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76141-1 [UniParc]FASTAAdd to Basket

« Hide

MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL    50
LEKGHQSGII RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG 100
RLGIGAAHML MSLLQPQQML AIGFGEATMN TLQRLSGFIS SQQIRLVTLS 150
GGVGSYMTGI GQLNAACSVN IIPAPLRASS ADIARTLKNE NCVKDVLLAA 200
QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA VGDILGYFFD 250
AKGDVVTNIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY 300
INALVTDQDT AAAILRS 317
Length:317
Mass (Da):33,797
Last modified:February 1, 1997 - v1
Checksum:iF9EAA1FE716A1F65
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 31779GAVGD…AILRS → RGGWRHFRLLF1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74585.1.
AP009048 Genomic DNA. Translation: BAA15192.2.
PIRiC64905.
RefSeqiNP_416029.1. NC_000913.3.
YP_489775.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74585; AAC74585; b1512.
BAA15192; BAA15192; BAA15192.
GeneIDi12931231.
946070.
KEGGiecj:Y75_p1487.
eco:b1512.
PATRICi32118320. VBIEscCol129921_1580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74585.1 .
AP009048 Genomic DNA. Translation: BAA15192.2 .
PIRi C64905.
RefSeqi NP_416029.1. NC_000913.3.
YP_489775.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GO1 X-ray 3.00 A/B 1-317 [» ]
4L4Y X-ray 1.90 A/B 53-317 [» ]
4L4Z X-ray 2.30 A/B 53-317 [» ]
4L50 X-ray 2.10 A/B 53-317 [» ]
4L51 X-ray 1.90 A/B 53-317 [» ]
4L5I X-ray 3.21 A/B/C/D 1-317 [» ]
4L5J X-ray 2.60 A/B/C/D 1-317 [» ]
ProteinModelPortali P76141.
SMRi P76141. Positions 10-317.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-11688N.
IntActi P76141. 5 interactions.
STRINGi 511145.b1512.

Proteomic databases

PaxDbi P76141.
PRIDEi P76141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74585 ; AAC74585 ; b1512 .
BAA15192 ; BAA15192 ; BAA15192 .
GeneIDi 12931231.
946070.
KEGGi ecj:Y75_p1487.
eco:b1512.
PATRICi 32118320. VBIEscCol129921_1580.

Organism-specific databases

EchoBASEi EB3566.
EcoGenei EG13805. lsrR.

Phylogenomic databases

eggNOGi COG2390.
HOGENOMi HOG000243107.
KOi K11531.
OMAi ADMQIHQ.
OrthoDBi EOG6GTZKW.
PhylomeDBi P76141.

Enzyme and pathway databases

BioCyci EcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Miscellaneous databases

PROi P76141.

Gene expression databases

Genevestigatori P76141.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF04198. Sugar-bind. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 239-317.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli."
    Xavier K.B., Bassler B.L.
    J. Bacteriol. 187:238-248(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli."
    Wang L., Hashimoto Y., Tsao C.-Y., Valdes J.J., Bentley W.E.
    J. Bacteriol. 187:2066-2076(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture."
    Li J., Attila C., Wang L., Wood T.K., Valdes J.J., Bentley W.E.
    J. Bacteriol. 189:6011-6020(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A GLOBAL REGULATOR.

Entry informationi

Entry nameiLSRR_ECOLI
AccessioniPrimary (citable) accession number: P76141
Secondary accession number(s): P77190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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