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P76141 (LSRR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulator LsrR
Gene names
Name:lsrR
Synonyms:ydeW
Ordered Locus Names:b1512, JW1505
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. Ref.4 Ref.5 Ref.6

Subcellular location

Cytoplasm Potential.

Induction

Autoregulated.

Sequence similarities

Belongs to the SorC transcriptional regulatory family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   LigandDNA-binding
   Molecular functionActivator
Repressor
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from expression pattern Ref.5. Source: EcoCyc

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Transcriptional regulator LsrR
PRO_0000062790

Regions

DNA binding33 – 5220H-T-H motif Potential

Experimental info

Sequence conflict239 – 31779GAVGD…AILRS → RGGWRHFRLLF Ref.1

Secondary structure

...................................................... 317
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P76141 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: F9EAA1FE716A1F65

FASTA31733,797
        10         20         30         40         50         60 
MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL LEKGHQSGII 

        70         80         90        100        110        120 
RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG RLGIGAAHML MSLLQPQQML 

       130        140        150        160        170        180 
AIGFGEATMN TLQRLSGFIS SQQIRLVTLS GGVGSYMTGI GQLNAACSVN IIPAPLRASS 

       190        200        210        220        230        240 
ADIARTLKNE NCVKDVLLAA QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA 

       250        260        270        280        290        300 
VGDILGYFFD AKGDVVTNIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY 

       310 
INALVTDQDT AAAILRS 

« Hide

References

« Hide 'large scale' references
[1]"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map."
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. expand/collapse author list , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:363-377(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 239-317.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli."
Xavier K.B., Bassler B.L.
J. Bacteriol. 187:238-248(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: K12 / MG1655 / ATCC 47076.
[5]"Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli."
Wang L., Hashimoto Y., Tsao C.-Y., Valdes J.J., Bentley W.E.
J. Bacteriol. 187:2066-2076(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture."
Li J., Attila C., Wang L., Wood T.K., Valdes J.J., Bentley W.E.
J. Bacteriol. 189:6011-6020(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A GLOBAL REGULATOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC74585.1.
AP009048 Genomic DNA. Translation: BAA15192.2.
PIRC64905.
RefSeqNP_416029.1. NC_000913.3.
YP_489775.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GO1X-ray3.00A/B1-317[»]
4L4YX-ray1.90A/B53-317[»]
4L4ZX-ray2.30A/B53-317[»]
4L50X-ray2.10A/B53-317[»]
4L51X-ray1.90A/B53-317[»]
4L5IX-ray3.21A/B/C/D1-317[»]
4L5JX-ray2.60A/B/C/D1-317[»]
ProteinModelPortalP76141.
SMRP76141. Positions 10-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-11688N.
IntActP76141. 5 interactions.
STRING511145.b1512.

Proteomic databases

PaxDbP76141.
PRIDEP76141.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74585; AAC74585; b1512.
BAA15192; BAA15192; BAA15192.
GeneID12931231.
946070.
KEGGecj:Y75_p1487.
eco:b1512.
PATRIC32118320. VBIEscCol129921_1580.

Organism-specific databases

EchoBASEEB3566.
EcoGeneEG13805. lsrR.

Phylogenomic databases

eggNOGCOG2390.
HOGENOMHOG000243107.
KOK11531.
OMAGERCITV.
OrthoDBEOG6GTZKW.
PhylomeDBP76141.
ProtClustDBPRK15418.

Enzyme and pathway databases

BioCycEcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Gene expression databases

GenevestigatorP76141.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF04198. Sugar-bind. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP76141.

Entry information

Entry nameLSRR_ECOLI
AccessionPrimary (citable) accession number: P76141
Secondary accession number(s): P77190
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene