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Protein

Transcriptional regulator LsrR

Gene

lsrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 5220H-T-H motifSequence AnalysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to heat Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator LsrR
Gene namesi
Name:lsrR
Synonyms:ydeW
Ordered Locus Names:b1512, JW1505
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13805. lsrR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Transcriptional regulator LsrRPRO_0000062790Add
BLAST

Proteomic databases

PaxDbiP76141.
PRIDEiP76141.

Expressioni

Inductioni

Autoregulated.

Interactioni

Protein-protein interaction databases

DIPiDIP-11688N.
IntActiP76141. 5 interactions.
STRINGi511145.b1512.

Structurei

Secondary structure

1
317
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 2713Combined sources
Helixi35 – 406Combined sources
Helixi44 – 5714Combined sources
Beta strandi58 – 647Combined sources
Helixi71 – 8111Combined sources
Beta strandi85 – 906Combined sources
Helixi98 – 11316Combined sources
Beta strandi119 – 1224Combined sources
Helixi126 – 14116Combined sources
Beta strandi145 – 1517Combined sources
Helixi154 – 1563Combined sources
Helixi157 – 1604Combined sources
Beta strandi161 – 1633Combined sources
Beta strandi165 – 1673Combined sources
Helixi181 – 1899Combined sources
Helixi191 – 20111Combined sources
Beta strandi204 – 2085Combined sources
Helixi213 – 2186Combined sources
Helixi220 – 2234Combined sources
Helixi229 – 2379Combined sources
Beta strandi242 – 2443Combined sources
Beta strandi247 – 2493Combined sources
Helixi261 – 2644Combined sources
Helixi270 – 2734Combined sources
Beta strandi276 – 2827Combined sources
Helixi286 – 2883Combined sources
Helixi289 – 2979Combined sources
Beta strandi302 – 3076Combined sources
Helixi308 – 3158Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GO1X-ray3.00A/B1-317[»]
4L4YX-ray1.90A/B53-317[»]
4L4ZX-ray2.30A/B53-317[»]
4L50X-ray2.10A/B53-317[»]
4L51X-ray1.90A/B53-317[»]
4L5IX-ray3.21A/B/C/D1-317[»]
4L5JX-ray2.60A/B/C/D1-317[»]
ProteinModelPortaliP76141.
SMRiP76141. Positions 10-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2390.
HOGENOMiHOG000243107.
InParanoidiP76141.
KOiK11531.
OMAiRSAMRMG.
OrthoDBiEOG6GTZKW.
PhylomeDBiP76141.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04198. Sugar-bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL
60 70 80 90 100
LEKGHQSGII RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG
110 120 130 140 150
RLGIGAAHML MSLLQPQQML AIGFGEATMN TLQRLSGFIS SQQIRLVTLS
160 170 180 190 200
GGVGSYMTGI GQLNAACSVN IIPAPLRASS ADIARTLKNE NCVKDVLLAA
210 220 230 240 250
QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA VGDILGYFFD
260 270 280 290 300
AKGDVVTNIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY
310
INALVTDQDT AAAILRS
Length:317
Mass (Da):33,797
Last modified:February 1, 1997 - v1
Checksum:iF9EAA1FE716A1F65
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 31779GAVGD…AILRS → RGGWRHFRLLF (PubMed:9097039).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74585.1.
AP009048 Genomic DNA. Translation: BAA15192.2.
PIRiC64905.
RefSeqiNP_416029.1. NC_000913.3.
WP_000154342.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC74585; AAC74585; b1512.
BAA15192; BAA15192; BAA15192.
GeneIDi946070.
KEGGieco:b1512.
PATRICi32118320. VBIEscCol129921_1580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74585.1.
AP009048 Genomic DNA. Translation: BAA15192.2.
PIRiC64905.
RefSeqiNP_416029.1. NC_000913.3.
WP_000154342.1. NZ_CP010445.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GO1X-ray3.00A/B1-317[»]
4L4YX-ray1.90A/B53-317[»]
4L4ZX-ray2.30A/B53-317[»]
4L50X-ray2.10A/B53-317[»]
4L51X-ray1.90A/B53-317[»]
4L5IX-ray3.21A/B/C/D1-317[»]
4L5JX-ray2.60A/B/C/D1-317[»]
ProteinModelPortaliP76141.
SMRiP76141. Positions 10-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-11688N.
IntActiP76141. 5 interactions.
STRINGi511145.b1512.

Proteomic databases

PaxDbiP76141.
PRIDEiP76141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74585; AAC74585; b1512.
BAA15192; BAA15192; BAA15192.
GeneIDi946070.
KEGGieco:b1512.
PATRICi32118320. VBIEscCol129921_1580.

Organism-specific databases

EchoBASEiEB3566.
EcoGeneiEG13805. lsrR.

Phylogenomic databases

eggNOGiCOG2390.
HOGENOMiHOG000243107.
InParanoidiP76141.
KOiK11531.
OMAiRSAMRMG.
OrthoDBiEOG6GTZKW.
PhylomeDBiP76141.

Enzyme and pathway databases

BioCyciEcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Miscellaneous databases

PROiP76141.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04198. Sugar-bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 239-317.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli."
    Xavier K.B., Bassler B.L.
    J. Bacteriol. 187:238-248(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli."
    Wang L., Hashimoto Y., Tsao C.-Y., Valdes J.J., Bentley W.E.
    J. Bacteriol. 187:2066-2076(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture."
    Li J., Attila C., Wang L., Wood T.K., Valdes J.J., Bentley W.E.
    J. Bacteriol. 189:6011-6020(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A GLOBAL REGULATOR.

Entry informationi

Entry nameiLSRR_ECOLI
AccessioniPrimary (citable) accession number: P76141
Secondary accession number(s): P77190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.