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P76141

- LSRR_ECOLI

UniProt

P76141 - LSRR_ECOLI

Protein

Transcriptional regulator LsrR

Gene

lsrR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. response to heat Source: EcoCyc
    3. transcription, DNA-templated Source: EcoCyc

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:G6799-MONOMER.
    ECOL316407:JW1505-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulator LsrR
    Gene namesi
    Name:lsrR
    Synonyms:ydeW
    Ordered Locus Names:b1512, JW1505
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13805. lsrR.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Transcriptional regulator LsrRPRO_0000062790Add
    BLAST

    Proteomic databases

    PaxDbiP76141.
    PRIDEiP76141.

    Expressioni

    Inductioni

    Autoregulated.

    Gene expression databases

    GenevestigatoriP76141.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-11688N.
    IntActiP76141. 5 interactions.
    STRINGi511145.b1512.

    Structurei

    Secondary structure

    1
    317
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi15 – 2713
    Helixi35 – 406
    Helixi44 – 5714
    Beta strandi58 – 647
    Helixi71 – 8111
    Beta strandi85 – 906
    Helixi98 – 11316
    Beta strandi119 – 1224
    Helixi126 – 14116
    Beta strandi145 – 1517
    Helixi154 – 1563
    Helixi157 – 1604
    Beta strandi161 – 1633
    Beta strandi165 – 1673
    Helixi181 – 1899
    Helixi191 – 20111
    Beta strandi204 – 2085
    Helixi213 – 2186
    Helixi220 – 2234
    Helixi229 – 2379
    Beta strandi242 – 2443
    Beta strandi247 – 2493
    Helixi261 – 2644
    Helixi270 – 2734
    Beta strandi276 – 2827
    Helixi286 – 2883
    Helixi289 – 2979
    Beta strandi302 – 3076
    Helixi308 – 3158

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GO1X-ray3.00A/B1-317[»]
    4L4YX-ray1.90A/B53-317[»]
    4L4ZX-ray2.30A/B53-317[»]
    4L50X-ray2.10A/B53-317[»]
    4L51X-ray1.90A/B53-317[»]
    4L5IX-ray3.21A/B/C/D1-317[»]
    4L5JX-ray2.60A/B/C/D1-317[»]
    ProteinModelPortaliP76141.
    SMRiP76141. Positions 10-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2390.
    HOGENOMiHOG000243107.
    KOiK11531.
    OMAiADMQIHQ.
    OrthoDBiEOG6GTZKW.
    PhylomeDBiP76141.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR007324. Sugar-bd_dom_put.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF04198. Sugar-bind. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P76141-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL    50
    LEKGHQSGII RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG 100
    RLGIGAAHML MSLLQPQQML AIGFGEATMN TLQRLSGFIS SQQIRLVTLS 150
    GGVGSYMTGI GQLNAACSVN IIPAPLRASS ADIARTLKNE NCVKDVLLAA 200
    QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA VGDILGYFFD 250
    AKGDVVTNIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY 300
    INALVTDQDT AAAILRS 317
    Length:317
    Mass (Da):33,797
    Last modified:February 1, 1997 - v1
    Checksum:iF9EAA1FE716A1F65
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 31779GAVGD…AILRS → RGGWRHFRLLF(PubMed:9097039)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74585.1.
    AP009048 Genomic DNA. Translation: BAA15192.2.
    PIRiC64905.
    RefSeqiNP_416029.1. NC_000913.3.
    YP_489775.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74585; AAC74585; b1512.
    BAA15192; BAA15192; BAA15192.
    GeneIDi12931231.
    946070.
    KEGGiecj:Y75_p1487.
    eco:b1512.
    PATRICi32118320. VBIEscCol129921_1580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC74585.1 .
    AP009048 Genomic DNA. Translation: BAA15192.2 .
    PIRi C64905.
    RefSeqi NP_416029.1. NC_000913.3.
    YP_489775.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GO1 X-ray 3.00 A/B 1-317 [» ]
    4L4Y X-ray 1.90 A/B 53-317 [» ]
    4L4Z X-ray 2.30 A/B 53-317 [» ]
    4L50 X-ray 2.10 A/B 53-317 [» ]
    4L51 X-ray 1.90 A/B 53-317 [» ]
    4L5I X-ray 3.21 A/B/C/D 1-317 [» ]
    4L5J X-ray 2.60 A/B/C/D 1-317 [» ]
    ProteinModelPortali P76141.
    SMRi P76141. Positions 10-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-11688N.
    IntActi P76141. 5 interactions.
    STRINGi 511145.b1512.

    Proteomic databases

    PaxDbi P76141.
    PRIDEi P76141.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74585 ; AAC74585 ; b1512 .
    BAA15192 ; BAA15192 ; BAA15192 .
    GeneIDi 12931231.
    946070.
    KEGGi ecj:Y75_p1487.
    eco:b1512.
    PATRICi 32118320. VBIEscCol129921_1580.

    Organism-specific databases

    EchoBASEi EB3566.
    EcoGenei EG13805. lsrR.

    Phylogenomic databases

    eggNOGi COG2390.
    HOGENOMi HOG000243107.
    KOi K11531.
    OMAi ADMQIHQ.
    OrthoDBi EOG6GTZKW.
    PhylomeDBi P76141.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6799-MONOMER.
    ECOL316407:JW1505-MONOMER.

    Miscellaneous databases

    PROi P76141.

    Gene expression databases

    Genevestigatori P76141.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR007324. Sugar-bd_dom_put.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF04198. Sugar-bind. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 239-317.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli."
      Xavier K.B., Bassler B.L.
      J. Bacteriol. 187:238-248(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: K12 / MG1655 / ATCC 47076.
    5. "Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli."
      Wang L., Hashimoto Y., Tsao C.-Y., Valdes J.J., Bentley W.E.
      J. Bacteriol. 187:2066-2076(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture."
      Li J., Attila C., Wang L., Wood T.K., Valdes J.J., Bentley W.E.
      J. Bacteriol. 189:6011-6020(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A GLOBAL REGULATOR.

    Entry informationi

    Entry nameiLSRR_ECOLI
    AccessioniPrimary (citable) accession number: P76141
    Secondary accession number(s): P77190
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3