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Protein

Transcriptional regulator LsrR

Gene

lsrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

  • bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding Source: EcoCyc
  • carbohydrate binding Source: InterPro
  • identical protein binding Source: EcoCyc

GO - Biological processi

  • regulation of DNA-templated transcription, initiation Source: EcoCyc
  • response to heat Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator LsrR
Gene namesi
Name:lsrR
Synonyms:ydeW
Ordered Locus Names:b1512, JW1505
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13805. lsrR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000627901 – 317Transcriptional regulator LsrRAdd BLAST317

Proteomic databases

PaxDbiP76141.
PRIDEiP76141.

Expressioni

Inductioni

Autoregulated.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4260225. 8 interactors.
DIPiDIP-11688N.
IntActiP76141. 5 interactors.
STRINGi511145.b1512.

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 27Combined sources13
Helixi35 – 40Combined sources6
Helixi44 – 57Combined sources14
Beta strandi58 – 64Combined sources7
Helixi71 – 81Combined sources11
Beta strandi85 – 90Combined sources6
Helixi98 – 113Combined sources16
Beta strandi119 – 122Combined sources4
Helixi126 – 141Combined sources16
Beta strandi145 – 151Combined sources7
Helixi154 – 156Combined sources3
Helixi157 – 160Combined sources4
Beta strandi161 – 163Combined sources3
Beta strandi165 – 167Combined sources3
Helixi181 – 189Combined sources9
Helixi191 – 201Combined sources11
Beta strandi204 – 208Combined sources5
Helixi213 – 218Combined sources6
Helixi220 – 223Combined sources4
Helixi229 – 237Combined sources9
Beta strandi242 – 244Combined sources3
Beta strandi247 – 249Combined sources3
Helixi261 – 264Combined sources4
Helixi270 – 273Combined sources4
Beta strandi276 – 282Combined sources7
Helixi286 – 288Combined sources3
Helixi289 – 297Combined sources9
Beta strandi302 – 307Combined sources6
Helixi308 – 315Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GO1X-ray3.00A/B1-317[»]
4L4YX-ray1.90A/B53-317[»]
4L4ZX-ray2.30A/B53-317[»]
4L50X-ray2.10A/B53-317[»]
4L51X-ray1.90A/B53-317[»]
4L5IX-ray3.21A/B/C/D1-317[»]
4L5JX-ray2.60A/B/C/D1-317[»]
ProteinModelPortaliP76141.
SMRiP76141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DKT. Bacteria.
COG2390. LUCA.
HOGENOMiHOG000243107.
InParanoidiP76141.
KOiK11531.
OMAiHQIMETA.
PhylomeDBiP76141.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04198. Sugar-bind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTINDSAISE QGMCEEEQVA RIAWFYYHDG LTQSEISDRL GLTRLKVSRL
60 70 80 90 100
LEKGHQSGII RVQINSRFEG CLEYETQLRR QFSLQHVRVI PGLADADVGG
110 120 130 140 150
RLGIGAAHML MSLLQPQQML AIGFGEATMN TLQRLSGFIS SQQIRLVTLS
160 170 180 190 200
GGVGSYMTGI GQLNAACSVN IIPAPLRASS ADIARTLKNE NCVKDVLLAA
210 220 230 240 250
QAADVAIVGI GAVSQQDDAT IIRSGYISQG EQLMIGRKGA VGDILGYFFD
260 270 280 290 300
AKGDVVTNIK IHNELIGLPL SALKTIPVRV GVAGGENKAE AIAAAMKGGY
310
INALVTDQDT AAAILRS
Length:317
Mass (Da):33,797
Last modified:February 1, 1997 - v1
Checksum:iF9EAA1FE716A1F65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239 – 317GAVGD…AILRS → RGGWRHFRLLF (PubMed:9097039).CuratedAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74585.1.
AP009048 Genomic DNA. Translation: BAA15192.2.
PIRiC64905.
RefSeqiNP_416029.1. NC_000913.3.
WP_000154342.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74585; AAC74585; b1512.
BAA15192; BAA15192; BAA15192.
GeneIDi946070.
KEGGiecj:JW1505.
eco:b1512.
PATRICi32118320. VBIEscCol129921_1580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74585.1.
AP009048 Genomic DNA. Translation: BAA15192.2.
PIRiC64905.
RefSeqiNP_416029.1. NC_000913.3.
WP_000154342.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GO1X-ray3.00A/B1-317[»]
4L4YX-ray1.90A/B53-317[»]
4L4ZX-ray2.30A/B53-317[»]
4L50X-ray2.10A/B53-317[»]
4L51X-ray1.90A/B53-317[»]
4L5IX-ray3.21A/B/C/D1-317[»]
4L5JX-ray2.60A/B/C/D1-317[»]
ProteinModelPortaliP76141.
SMRiP76141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260225. 8 interactors.
DIPiDIP-11688N.
IntActiP76141. 5 interactors.
STRINGi511145.b1512.

Proteomic databases

PaxDbiP76141.
PRIDEiP76141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74585; AAC74585; b1512.
BAA15192; BAA15192; BAA15192.
GeneIDi946070.
KEGGiecj:JW1505.
eco:b1512.
PATRICi32118320. VBIEscCol129921_1580.

Organism-specific databases

EchoBASEiEB3566.
EcoGeneiEG13805. lsrR.

Phylogenomic databases

eggNOGiENOG4105DKT. Bacteria.
COG2390. LUCA.
HOGENOMiHOG000243107.
InParanoidiP76141.
KOiK11531.
OMAiHQIMETA.
PhylomeDBiP76141.

Enzyme and pathway databases

BioCyciEcoCyc:G6799-MONOMER.
ECOL316407:JW1505-MONOMER.

Miscellaneous databases

PROiP76141.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR007324. Sugar-bd_dom_put.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04198. Sugar-bind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSRR_ECOLI
AccessioniPrimary (citable) accession number: P76141
Secondary accession number(s): P77190
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.