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Protein

Two-component-system connector protein SafA

Gene

safA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions.1 Publication

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2841

Names & Taxonomyi

Protein namesi
Recommended name:
Two-component-system connector protein SafA
Alternative name(s):
Regulatory protein b1500
Sensor associating factor A
Gene namesi
Name:safA
Synonyms:yneN
Ordered Locus Names:b1500, JW1494.1
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14466 safA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18Cytoplasmic1 PublicationAdd BLAST18
Transmembranei19 – 39Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini40 – 65Periplasmic1 PublicationAdd BLAST26

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002237151 – 65Two-component-system connector protein SafAAdd BLAST65

Proteomic databases

PaxDbiP76136
PRIDEiP76136

Expressioni

Inductioni

By acid stress, via the EvgS/EvgA system.2 Publications

Interactioni

Subunit structurei

Interacts with PhoQ.1 Publication

Protein-protein interaction databases

DIPiDIP-46181N
IntActiP76136, 1 interactor
STRINGi511145.b1500

Structurei

3D structure databases

ProteinModelPortaliP76136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SafA family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000059395
OMAiNYKGIMS

Family and domain databases

InterProiView protein in InterPro
IPR031411 SafA
PfamiView protein in Pfam
PF17073 SafA, 1 hit

Sequencei

Sequence statusi: Complete.

P76136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHATTVKNKI TQRDNYKEIM SAIVVVLLLT LTLIAIFSAI DQLSISEMGR
60
IARDLTHFII NSLQG
Length:65
Mass (Da):7,272
Last modified:February 1, 1997 - v1
Checksum:i10ECD1B9EE15463E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74573.1
AP009048 Genomic DNA No translation available.
PIRiG64903
RefSeqiNP_416017.1, NC_000913.3
WP_000543384.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74573; AAC74573; b1500
GeneIDi946061
KEGGieco:b1500
PATRICifig|1411691.4.peg.766

Entry informationi

Entry nameiSAFA_ECOLI
AccessioniPrimary (citable) accession number: P76136
Secondary accession number(s): B2D6K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health