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Protein

Anaerobic sulfatase-maturating enzyme homolog YdeM

Gene

ydeM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Curated
  • iron-sulfur clusterCuratedNote: May bind at least one other iron-sulfur cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis
Metal bindingi16 – 161Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis
Metal bindingi19 – 191Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis
Metal bindingi257 – 2571Iron-sulfurSequence analysis
Metal bindingi263 – 2631Iron-sulfurSequence analysis
Metal bindingi278 – 2781Iron-sulfurSequence analysis
Metal bindingi315 – 3151Iron-sulfurSequence analysis
Metal bindingi318 – 3181Iron-sulfurSequence analysis
Metal bindingi324 – 3241Iron-sulfurSequence analysis
Metal bindingi328 – 3281Iron-sulfurSequence analysis

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • protein maturation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:G6787-MONOMER.
ECOL316407:JW1492-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic sulfatase-maturating enzyme homolog YdeM
Short name:
AnSME homolog
Gene namesi
Name:ydeM
Ordered Locus Names:b1497, JW1492
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13795. ydeM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Anaerobic sulfatase-maturating enzyme homolog YdeMPRO_0000134463Add
BLAST

Proteomic databases

PaxDbiP76134.

Interactioni

Protein-protein interaction databases

BioGridi4260790. 10 interactions.
IntActiP76134. 1 interaction.
STRINGi511145.b1497.

Structurei

3D structure databases

ProteinModelPortaliP76134.
SMRiP76134. Positions 6-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C4X. Bacteria.
COG0641. LUCA.
HOGENOMiHOG000000300.
InParanoidiP76134.
KOiK06871.
OMAiINIFDEW.
PhylomeDBiP76134.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR023885. 4Fe4S-binding_SPASM_dom.
IPR013785. Aldolase_TIM.
IPR007197. rSAM.
IPR023867. Sulphatase_maturase_rSAM.
[Graphical view]
PfamiPF04055. Radical_SAM. 1 hit.
PF13186. SPASM. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04085. rSAM_more_4Fe4S. 1 hit.
TIGR03942. sulfatase_rSAM. 1 hit.

Sequencei

Sequence statusi: Complete.

P76134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVTAKPSSF QCNLKCDYCF YLEKESQFTH EKWMDDSTLK EFIKQYIAAS
60 70 80 90 100
GNQVYFTWQG GEPTLAGLDF FRKVIHYQQR YAGQKRIFNA LQTNGILLNN
110 120 130 140 150
EWCAFLKEHE FLVGISIDGP QELHDRYRRS NSGNGTFAKV IAAIERLKSY
160 170 180 190 200
QVEFNTLTVI NNVNVHYPLE VYHFLKSIGS KHMQFIELLE TGTPNIDFSG
210 220 230 240 250
HSENTFRIID FSVPPTAYGK FMSTIFMQWV KNDVGEIFIR QFESFVSRFL
260 270 280 290 300
GNGHTSCIFQ ESCKDNLVVE SNGDIYECDH FVYPQYKIGN INKSELKTMN
310 320 330 340 350
SVQLTAQKKR IPAKCQQCAY KPICNGGCPK HRITKVNNET VSYFCEGYKI
360 370 380
LFSTMVPYMN AMVELAKNRV PLYHIMDVAK QMENN
Length:385
Mass (Da):44,518
Last modified:July 15, 1998 - v2
Checksum:i964E34F73E680329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74570.2.
AP009048 Genomic DNA. Translation: BAA15168.1.
PIRiD64903.
RefSeqiNP_416014.4. NC_000913.3.
WP_001301030.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74570; AAC74570; b1497.
BAA15168; BAA15168; BAA15168.
GeneIDi945981.
KEGGiecj:JW1492.
eco:b1497.
PATRICi32118288. VBIEscCol129921_1564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74570.2.
AP009048 Genomic DNA. Translation: BAA15168.1.
PIRiD64903.
RefSeqiNP_416014.4. NC_000913.3.
WP_001301030.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76134.
SMRiP76134. Positions 6-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260790. 10 interactions.
IntActiP76134. 1 interaction.
STRINGi511145.b1497.

Proteomic databases

PaxDbiP76134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74570; AAC74570; b1497.
BAA15168; BAA15168; BAA15168.
GeneIDi945981.
KEGGiecj:JW1492.
eco:b1497.
PATRICi32118288. VBIEscCol129921_1564.

Organism-specific databases

EchoBASEiEB3556.
EcoGeneiEG13795. ydeM.

Phylogenomic databases

eggNOGiENOG4105C4X. Bacteria.
COG0641. LUCA.
HOGENOMiHOG000000300.
InParanoidiP76134.
KOiK06871.
OMAiINIFDEW.
PhylomeDBiP76134.

Enzyme and pathway databases

BioCyciEcoCyc:G6787-MONOMER.
ECOL316407:JW1492-MONOMER.

Miscellaneous databases

PROiP76134.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR023885. 4Fe4S-binding_SPASM_dom.
IPR013785. Aldolase_TIM.
IPR007197. rSAM.
IPR023867. Sulphatase_maturase_rSAM.
[Graphical view]
PfamiPF04055. Radical_SAM. 1 hit.
PF13186. SPASM. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04085. rSAM_more_4Fe4S. 1 hit.
TIGR03942. sulfatase_rSAM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYDEM_ECOLI
AccessioniPrimary (citable) accession number: P76134
Secondary accession number(s): P77755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Despite its homology to the anaerobic sulfatase-maturating enzymes, it is not involved in Cys-type sulfatase maturation in vivo.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.