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Protein

Anaerobic sulfatase-maturating enzyme homolog YdeM

Gene

ydeM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Despite its homology to the anaerobic sulfatase-maturating enzymes, it is not involved in Cys-type sulfatase maturation in vivo.Curated

Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Curated
  • iron-sulfur clusterCuratedNote: May bind at least one other iron-sulfur cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi16Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi19Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi257Iron-sulfurSequence analysis1
Metal bindingi263Iron-sulfurSequence analysis1
Metal bindingi278Iron-sulfurSequence analysis1
Metal bindingi315Iron-sulfurSequence analysis1
Metal bindingi318Iron-sulfurSequence analysis1
Metal bindingi324Iron-sulfurSequence analysis1
Metal bindingi328Iron-sulfurSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • protein maturation Source: EcoCyc

Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:G6787-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic sulfatase-maturating enzyme homolog YdeM
Short name:
AnSME homolog
Gene namesi
Name:ydeM
Ordered Locus Names:b1497, JW1492
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13795 ydeM

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001344631 – 385Anaerobic sulfatase-maturating enzyme homolog YdeMAdd BLAST385

Proteomic databases

PaxDbiP76134
PRIDEiP76134

Interactioni

Protein-protein interaction databases

BioGridi4260790, 10 interactors
IntActiP76134, 1 interactor
STRINGi316385.ECDH10B_1628

Structurei

3D structure databases

ProteinModelPortaliP76134
SMRiP76134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C4X Bacteria
COG0641 LUCA
HOGENOMiHOG000000300
InParanoidiP76134
KOiK06871
OMAiIYPCYRF
PhylomeDBiP76134

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR023885 4Fe4S-binding_SPASM_dom
IPR013785 Aldolase_TIM
IPR034491 Anaerob_Ser_sulfatase-maturase
IPR034481 Main_SPASM_domain-containing
IPR007197 rSAM
IPR034395 SPASM/twitch_domain-containing
IPR023867 Sulphatase_maturase_rSAM
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF13186 SPASM, 1 hit
SFLDiSFLDF00285 anaerobic_Ser-type_sulfatase-m, 1 hit
SFLDG01067 SPASM/twitch_domain_containing, 1 hit
SFLDG01072 dehydrogenase_like, 1 hit
SFLDG01386 main_SPASM_domain-containing, 1 hit
SFLDS00029 Radical_SAM, 1 hit
TIGRFAMsiTIGR04085 rSAM_more_4Fe4S, 1 hit
TIGR03942 sulfatase_rSAM, 1 hit

Sequencei

Sequence statusi: Complete.

P76134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVTAKPSSF QCNLKCDYCF YLEKESQFTH EKWMDDSTLK EFIKQYIAAS
60 70 80 90 100
GNQVYFTWQG GEPTLAGLDF FRKVIHYQQR YAGQKRIFNA LQTNGILLNN
110 120 130 140 150
EWCAFLKEHE FLVGISIDGP QELHDRYRRS NSGNGTFAKV IAAIERLKSY
160 170 180 190 200
QVEFNTLTVI NNVNVHYPLE VYHFLKSIGS KHMQFIELLE TGTPNIDFSG
210 220 230 240 250
HSENTFRIID FSVPPTAYGK FMSTIFMQWV KNDVGEIFIR QFESFVSRFL
260 270 280 290 300
GNGHTSCIFQ ESCKDNLVVE SNGDIYECDH FVYPQYKIGN INKSELKTMN
310 320 330 340 350
SVQLTAQKKR IPAKCQQCAY KPICNGGCPK HRITKVNNET VSYFCEGYKI
360 370 380
LFSTMVPYMN AMVELAKNRV PLYHIMDVAK QMENN
Length:385
Mass (Da):44,518
Last modified:July 15, 1998 - v2
Checksum:i964E34F73E680329
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74570.2
AP009048 Genomic DNA Translation: BAA15168.1
PIRiD64903
RefSeqiNP_416014.4, NC_000913.3
WP_001301030.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74570; AAC74570; b1497
BAA15168; BAA15168; BAA15168
GeneIDi945981
KEGGiecj:JW1492
eco:b1497
PATRICifig|511145.12.peg.1564

Entry informationi

Entry nameiYDEM_ECOLI
AccessioniPrimary (citable) accession number: P76134
Secondary accession number(s): P77755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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