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Protein

Probable D,D-dipeptide-binding periplasmic protein DdpA

Gene

ddpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDDS-MONOMER.
ECOL316407:JW5240-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D,D-dipeptide-binding periplasmic protein DdpA
Gene namesi
Name:ddpA
Synonyms:yddS
Ordered Locus Names:b1487, JW5240
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13790. ddpA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 516491Probable D,D-dipeptide-binding periplasmic protein DdpAPRO_0000031805Add
BLAST

Proteomic databases

EPDiP76128.
PaxDbiP76128.
PRIDEiP76128.

Expressioni

Inductioni

Induced by RpoS in stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA).Curated

Protein-protein interaction databases

BioGridi4261978. 352 interactions.
DIPiDIP-11672N.
IntActiP76128. 2 interactions.
STRINGi511145.b1487.

Structurei

3D structure databases

ProteinModelPortaliP76128.
SMRiP76128. Positions 37-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
HOGENOMiHOG000200399.
InParanoidiP76128.
KOiK02035.
OMAiFVNLGYE.
PhylomeDBiP76128.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSISFRPT LLALVLATNF PVAHAAVPKD MLVIGKAADP QTLDPAVTID
60 70 80 90 100
NNDWTVTYPS YQRLVQYKTD GDKGSTDVEG DLASSWKASD DQKEWTFTLK
110 120 130 140 150
DNAKFADGTP VTAEAVKLSF ERLLKIGQGP AEAFPKDLKI DAPDEHTVKF
160 170 180 190 200
TLSQPFAPFL YTLANDGASI INPAVLKEHA ADDARGFLAQ NTAGSGPFML
210 220 230 240 250
KSWQKGQQLV LVPNPHYPGN KPNFKRVSVK IIGESASRRL QLSRGDIDIA
260 270 280 290 300
DALPVDQLNA LKQENKVNVA EYPSLRVTYL YLNNSKAPLN QADLRRAISW
310 320 330 340 350
STDYQGMVNG ILSGNGKQMR GPIPEGMWGY DATAMQYNHD ETKAKAEWDK
360 370 380 390 400
VTSKPTSLTF LYSDNDPNWE PIALATQSSL NKLGIIVKLE KLANATMRDR
410 420 430 440 450
VGKGDYDIAI GNWSPDFADP YMFMNYWFES DKKGLPGNRS FYENSEVDKL
460 470 480 490 500
LRNALATTDQ TQRTRDYQQA QKIVIDDAAY VYLFQKNYQL AMNKEVKGFV
510
FNPMLEQVFN INTMSK
Length:516
Mass (Da):57,641
Last modified:February 1, 1997 - v1
Checksum:i86E1C32CC3E06FB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74560.1.
AP009048 Genomic DNA. Translation: BAA15142.2.
PIRiB64902.
RefSeqiNP_416004.1. NC_000913.3.
WP_000830550.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74560; AAC74560; b1487.
BAA15142; BAA15142; BAA15142.
GeneIDi946052.
KEGGiecj:JW5240.
eco:b1487.
PATRICi32118268. VBIEscCol129921_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74560.1.
AP009048 Genomic DNA. Translation: BAA15142.2.
PIRiB64902.
RefSeqiNP_416004.1. NC_000913.3.
WP_000830550.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76128.
SMRiP76128. Positions 37-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261978. 352 interactions.
DIPiDIP-11672N.
IntActiP76128. 2 interactions.
STRINGi511145.b1487.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Proteomic databases

EPDiP76128.
PaxDbiP76128.
PRIDEiP76128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74560; AAC74560; b1487.
BAA15142; BAA15142; BAA15142.
GeneIDi946052.
KEGGiecj:JW5240.
eco:b1487.
PATRICi32118268. VBIEscCol129921_1554.

Organism-specific databases

EchoBASEiEB3551.
EcoGeneiEG13790. ddpA.

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
HOGENOMiHOG000200399.
InParanoidiP76128.
KOiK02035.
OMAiFVNLGYE.
PhylomeDBiP76128.

Enzyme and pathway databases

BioCyciEcoCyc:YDDS-MONOMER.
ECOL316407:JW5240-MONOMER.

Miscellaneous databases

PROiP76128.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDPA_ECOLI
AccessioniPrimary (citable) accession number: P76128
Secondary accession number(s): P76874, P77769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.