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Protein

HTH-type transcriptional regulator McbR

Gene

mcbR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 56H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6761-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator McbR
Gene namesi
Name:mcbR
Synonyms:yncC
Ordered Locus Names:b1450, JW1445
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13773 mcbR

Pathology & Biotechi

Disruption phenotypei

Disruption of this gene induces 30 genes and represses 10 genes more than fourfold. It decreases biofilm formation, increases extracellular indole, leads to colanic acid overproduction and elicits mucoidy.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506861 – 221HTH-type transcriptional regulator McbRAdd BLAST221

Proteomic databases

PaxDbiP76114
PRIDEiP76114

Expressioni

Inductioni

Induced by LsrR, LsrK, MqsR and TqsA. Repressed by LuxS and YgiV.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rplCP604382EBI-560824,EBI-542200

Protein-protein interaction databases

BioGridi4260196, 3 interactors
DIPiDIP-12749N
IntActiP76114, 11 interactors
STRINGi316385.ECDH10B_1580

Structurei

3D structure databases

ProteinModelPortaliP76114
SMRiP76114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 77HTH gntR-typePROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiENOG4108WYP Bacteria
COG1802 LUCA
HOGENOMiHOG000273993
InParanoidiP76114
KOiK13654
OMAiSLTMQVE
PhylomeDBiP76114

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.20.120.530, 1 hit
InterProiView protein in InterPro
IPR011711 GntR_C
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07729 FCD, 1 hit
PF00392 GntR, 1 hit
SMARTiView protein in SMART
SM00895 FCD, 1 hit
SM00345 HTH_GNTR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48008 SSF48008, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P76114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTGKMKHV SLTLQVENDL KHQLSIGALK PGARLITKNL AEQLGMSITP
60 70 80 90 100
VREALLRLVS VNALSVAPAQ AFTVPEVGKR QLDEINRIRY ELELMAVALA
110 120 130 140 150
VENLTPQDLA ELQELLEKLQ QAQEKGDMEQ IINVNRLFRL AIYHRSNMPI
160 170 180 190 200
LCEMIEQLWV RMGPGLHYLY EAINPAELRE HIENYHLLLA ALKAKDKEGC
210 220
RHCLAEIMQQ NIAILYQQYN R
Length:221
Mass (Da):25,151
Last modified:July 15, 1999 - v2
Checksum:i7A589BCFAE20D75C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74532.2
AP009048 Genomic DNA Translation: BAA15082.1
PIRiE64897
RefSeqiNP_415967.2, NC_000913.3
WP_001300742.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74532; AAC74532; b1450
BAA15082; BAA15082; BAA15082
GeneIDi946014
KEGGiecj:JW1445
eco:b1450
PATRICifig|1411691.4.peg.818

Similar proteinsi

Entry informationi

Entry nameiMCBR_ECOLI
AccessioniPrimary (citable) accession number: P76114
Secondary accession number(s): P77347
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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