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P76086 (PAAX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional repressor PaaX
Gene names
Name:paaX
Synonyms:ydbY
Ordered Locus Names:b1399, JW1394
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'-WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA). Ref.1 Ref.4

Pathway

Aromatic compound metabolism; phenylacetate degradation.

Sequence similarities

Belongs to the PaaX family.

Ontologies

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Transcriptional repressor PaaX
PRO_0000058165

Natural variations

Natural variant51D → V in strain: W.
Natural variant3111L → I in strain: W.
Natural variant3151I → T in strain: W.

Sequences

Sequence LengthMass (Da)Tools
P76086 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 286C97DBC2564030

FASTA31635,295
        10         20         30         40         50         60 
MSKLDTFIQH AVNAVPVSGT SLISSLYGDS LSHRGGEIWL GSLAALLEGL GFGERFVRTA 

        70         80         90        100        110        120 
LFRLNKEGWL DVSRIGRRSF YSLSDKGLRL TRRAESKIYR AEQPAWDGKW LLLLSEGLDK 

       130        140        150        160        170        180 
STLADVKKQL IWQGFGALAP SLMASPSQKL ADVQTLLHEA GVADNVICFE AQIPLALSRA 

       190        200        210        220        230        240 
ALRARVEECW HLTEQNAMYE TFIQSFRPLV PLLKEAADEL TPERAFHIQL LLIHFYRRVV 

       250        260        270        280        290        300 
LKDPLLPEEL LPAHWAGHTA RQLCINIYQR VAPAALAFVS EKGETSVGEL PAPGSLYFQR 

       310 
FGGLNIEQEA LCQFIR 

« Hide

References

« Hide 'large scale' references
[1]"Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway."
Ferrandez A., Minambres B., Garcia B., Olivera E.R., Luengo J.M., Garcia J.L., Diaz E.
J. Biol. Chem. 273:25974-25986(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN PHENYLACETATE CATABOLISM.
Strain: W / ATCC 11105 / DSM 1900.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli."
Ferrandez A., Garcia J.L., Diaz E.
J. Biol. Chem. 275:12214-12222(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR, REGULATION BY PA-COA, CONSENSUS MOTIF.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97452 Genomic DNA. Translation: CAA66101.1.
U00096 Genomic DNA. Translation: AAC74481.1.
AP009048 Genomic DNA. Translation: BAE76429.1.
PIRB64891.
RefSeqNP_415917.1. NC_000913.3.
YP_489668.1. NC_007779.1.

3D structure databases

ProteinModelPortalP76086.
SMRP76086. Positions 11-277.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-10431N.
IntActP76086. 21 interactions.
STRING511145.b1399.

Proteomic databases

PaxDbP76086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74481; AAC74481; b1399.
BAE76429; BAE76429; BAE76429.
GeneID12934020.
945966.
KEGGecj:Y75_p1376.
eco:b1399.
PATRIC32118084. VBIEscCol129921_1462.

Organism-specific databases

EchoBASEEB3509.
EcoGeneEG13746. paaX.

Phylogenomic databases

eggNOGCOG3327.
HOGENOMHOG000147151.
KOK02616.
OMALLIHEYR.
OrthoDBEOG6TBHDM.
PhylomeDBP76086.
ProtClustDBCLSK891750.

Enzyme and pathway databases

BioCycEcoCyc:G6720-MONOMER.
ECOL316407:JW1394-MONOMER.
UniPathwayUPA00930.

Gene expression databases

GenevestigatorP76086.

Family and domain databases

InterProIPR012906. PaaX-like_N.
IPR013225. PaaX_C.
IPR011965. PaaX_trns_reg.
[Graphical view]
PfamPF07848. PaaX. 1 hit.
PF08223. PaaX_C. 1 hit.
[Graphical view]
PIRSFPIRSF020623. PaaX. 1 hit.
TIGRFAMsTIGR02277. PaaX_trns_reg. 1 hit.
ProtoNetSearch...

Other

PROP76086.

Entry information

Entry namePAAX_ECOLI
AccessionPrimary (citable) accession number: P76086
Secondary accession number(s): O53019, Q2MBC7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene