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P76086

- PAAX_ECOLI

UniProt

P76086 - PAAX_ECOLI

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Protein

Transcriptional repressor PaaX

Gene

paaX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'-WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA).2 Publications

Pathwayi

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. phenylacetate catabolic process Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6720-MONOMER.
ECOL316407:JW1394-MONOMER.
UniPathwayiUPA00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor PaaX
Gene namesi
Name:paaX
Synonyms:ydbY
Ordered Locus Names:b1399, JW1394
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13746. paaX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Transcriptional repressor PaaXPRO_0000058165Add
BLAST

Proteomic databases

PaxDbiP76086.

Expressioni

Gene expression databases

GenevestigatoriP76086.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cpxAP0AE823EBI-544692,EBI-9141330
gspHP414432EBI-544692,EBI-1129978

Protein-protein interaction databases

DIPiDIP-10431N.
IntActiP76086. 21 interactions.
STRINGi511145.b1399.

Structurei

3D structure databases

ProteinModelPortaliP76086.
SMRiP76086. Positions 11-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PaaX family.Curated

Phylogenomic databases

eggNOGiCOG3327.
HOGENOMiHOG000147151.
InParanoidiP76086.
KOiK02616.
OMAiLCRNLYR.
OrthoDBiEOG6TBHDM.
PhylomeDBiP76086.

Family and domain databases

InterProiIPR012906. PaaX-like_N.
IPR013225. PaaX_C.
IPR011965. PaaX_trns_reg.
[Graphical view]
PfamiPF07848. PaaX. 1 hit.
PF08223. PaaX_C. 1 hit.
[Graphical view]
PIRSFiPIRSF020623. PaaX. 1 hit.
TIGRFAMsiTIGR02277. PaaX_trns_reg. 1 hit.

Sequencei

Sequence statusi: Complete.

P76086-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLDTFIQH AVNAVPVSGT SLISSLYGDS LSHRGGEIWL GSLAALLEGL
60 70 80 90 100
GFGERFVRTA LFRLNKEGWL DVSRIGRRSF YSLSDKGLRL TRRAESKIYR
110 120 130 140 150
AEQPAWDGKW LLLLSEGLDK STLADVKKQL IWQGFGALAP SLMASPSQKL
160 170 180 190 200
ADVQTLLHEA GVADNVICFE AQIPLALSRA ALRARVEECW HLTEQNAMYE
210 220 230 240 250
TFIQSFRPLV PLLKEAADEL TPERAFHIQL LLIHFYRRVV LKDPLLPEEL
260 270 280 290 300
LPAHWAGHTA RQLCINIYQR VAPAALAFVS EKGETSVGEL PAPGSLYFQR
310
FGGLNIEQEA LCQFIR
Length:316
Mass (Da):35,295
Last modified:February 1, 1997 - v1
Checksum:i286C97DBC2564030
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51D → V in strain: W.
Natural varianti311 – 3111L → I in strain: W.
Natural varianti315 – 3151I → T in strain: W.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97452 Genomic DNA. Translation: CAA66101.1.
U00096 Genomic DNA. Translation: AAC74481.1.
AP009048 Genomic DNA. Translation: BAE76429.1.
PIRiB64891.
RefSeqiNP_415917.1. NC_000913.3.
YP_489668.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74481; AAC74481; b1399.
BAE76429; BAE76429; BAE76429.
GeneIDi12934020.
945966.
KEGGiecj:Y75_p1376.
eco:b1399.
PATRICi32118084. VBIEscCol129921_1462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97452 Genomic DNA. Translation: CAA66101.1 .
U00096 Genomic DNA. Translation: AAC74481.1 .
AP009048 Genomic DNA. Translation: BAE76429.1 .
PIRi B64891.
RefSeqi NP_415917.1. NC_000913.3.
YP_489668.1. NC_007779.1.

3D structure databases

ProteinModelPortali P76086.
SMRi P76086. Positions 11-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-10431N.
IntActi P76086. 21 interactions.
STRINGi 511145.b1399.

Proteomic databases

PaxDbi P76086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74481 ; AAC74481 ; b1399 .
BAE76429 ; BAE76429 ; BAE76429 .
GeneIDi 12934020.
945966.
KEGGi ecj:Y75_p1376.
eco:b1399.
PATRICi 32118084. VBIEscCol129921_1462.

Organism-specific databases

EchoBASEi EB3509.
EcoGenei EG13746. paaX.

Phylogenomic databases

eggNOGi COG3327.
HOGENOMi HOG000147151.
InParanoidi P76086.
KOi K02616.
OMAi LCRNLYR.
OrthoDBi EOG6TBHDM.
PhylomeDBi P76086.

Enzyme and pathway databases

UniPathwayi UPA00930 .
BioCyci EcoCyc:G6720-MONOMER.
ECOL316407:JW1394-MONOMER.

Miscellaneous databases

PROi P76086.

Gene expression databases

Genevestigatori P76086.

Family and domain databases

InterProi IPR012906. PaaX-like_N.
IPR013225. PaaX_C.
IPR011965. PaaX_trns_reg.
[Graphical view ]
Pfami PF07848. PaaX. 1 hit.
PF08223. PaaX_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF020623. PaaX. 1 hit.
TIGRFAMsi TIGR02277. PaaX_trns_reg. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway."
    Ferrandez A., Minambres B., Garcia B., Olivera E.R., Luengo J.M., Garcia J.L., Diaz E.
    J. Biol. Chem. 273:25974-25986(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN PHENYLACETATE CATABOLISM.
    Strain: W / ATCC 11105 / DSM 1900.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli."
    Ferrandez A., Garcia J.L., Diaz E.
    J. Biol. Chem. 275:12214-12222(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR, REGULATION BY PA-COA, CONSENSUS MOTIF.

Entry informationi

Entry nameiPAAX_ECOLI
AccessioniPrimary (citable) accession number: P76086
Secondary accession number(s): O53019, Q2MBC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3