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P76086

- PAAX_ECOLI

UniProt

P76086 - PAAX_ECOLI

Protein

Transcriptional repressor PaaX

Gene

paaX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'-WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA).2 Publications

    Pathwayi

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. phenylacetate catabolic process Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: EcoCyc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:G6720-MONOMER.
    ECOL316407:JW1394-MONOMER.
    UniPathwayiUPA00930.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional repressor PaaX
    Gene namesi
    Name:paaX
    Synonyms:ydbY
    Ordered Locus Names:b1399, JW1394
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13746. paaX.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Transcriptional repressor PaaXPRO_0000058165Add
    BLAST

    Proteomic databases

    PaxDbiP76086.

    Expressioni

    Gene expression databases

    GenevestigatoriP76086.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    cpxAP0AE823EBI-544692,EBI-9141330
    gspHP414432EBI-544692,EBI-1129978

    Protein-protein interaction databases

    DIPiDIP-10431N.
    IntActiP76086. 21 interactions.
    STRINGi511145.b1399.

    Structurei

    3D structure databases

    ProteinModelPortaliP76086.
    SMRiP76086. Positions 11-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PaaX family.Curated

    Phylogenomic databases

    eggNOGiCOG3327.
    HOGENOMiHOG000147151.
    KOiK02616.
    OMAiLCRNLYR.
    OrthoDBiEOG6TBHDM.
    PhylomeDBiP76086.

    Family and domain databases

    InterProiIPR012906. PaaX-like_N.
    IPR013225. PaaX_C.
    IPR011965. PaaX_trns_reg.
    [Graphical view]
    PfamiPF07848. PaaX. 1 hit.
    PF08223. PaaX_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF020623. PaaX. 1 hit.
    TIGRFAMsiTIGR02277. PaaX_trns_reg. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P76086-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKLDTFIQH AVNAVPVSGT SLISSLYGDS LSHRGGEIWL GSLAALLEGL    50
    GFGERFVRTA LFRLNKEGWL DVSRIGRRSF YSLSDKGLRL TRRAESKIYR 100
    AEQPAWDGKW LLLLSEGLDK STLADVKKQL IWQGFGALAP SLMASPSQKL 150
    ADVQTLLHEA GVADNVICFE AQIPLALSRA ALRARVEECW HLTEQNAMYE 200
    TFIQSFRPLV PLLKEAADEL TPERAFHIQL LLIHFYRRVV LKDPLLPEEL 250
    LPAHWAGHTA RQLCINIYQR VAPAALAFVS EKGETSVGEL PAPGSLYFQR 300
    FGGLNIEQEA LCQFIR 316
    Length:316
    Mass (Da):35,295
    Last modified:February 1, 1997 - v1
    Checksum:i286C97DBC2564030
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51D → V in strain: W.
    Natural varianti311 – 3111L → I in strain: W.
    Natural varianti315 – 3151I → T in strain: W.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97452 Genomic DNA. Translation: CAA66101.1.
    U00096 Genomic DNA. Translation: AAC74481.1.
    AP009048 Genomic DNA. Translation: BAE76429.1.
    PIRiB64891.
    RefSeqiNP_415917.1. NC_000913.3.
    YP_489668.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74481; AAC74481; b1399.
    BAE76429; BAE76429; BAE76429.
    GeneIDi12934020.
    945966.
    KEGGiecj:Y75_p1376.
    eco:b1399.
    PATRICi32118084. VBIEscCol129921_1462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97452 Genomic DNA. Translation: CAA66101.1 .
    U00096 Genomic DNA. Translation: AAC74481.1 .
    AP009048 Genomic DNA. Translation: BAE76429.1 .
    PIRi B64891.
    RefSeqi NP_415917.1. NC_000913.3.
    YP_489668.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P76086.
    SMRi P76086. Positions 11-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-10431N.
    IntActi P76086. 21 interactions.
    STRINGi 511145.b1399.

    Proteomic databases

    PaxDbi P76086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74481 ; AAC74481 ; b1399 .
    BAE76429 ; BAE76429 ; BAE76429 .
    GeneIDi 12934020.
    945966.
    KEGGi ecj:Y75_p1376.
    eco:b1399.
    PATRICi 32118084. VBIEscCol129921_1462.

    Organism-specific databases

    EchoBASEi EB3509.
    EcoGenei EG13746. paaX.

    Phylogenomic databases

    eggNOGi COG3327.
    HOGENOMi HOG000147151.
    KOi K02616.
    OMAi LCRNLYR.
    OrthoDBi EOG6TBHDM.
    PhylomeDBi P76086.

    Enzyme and pathway databases

    UniPathwayi UPA00930 .
    BioCyci EcoCyc:G6720-MONOMER.
    ECOL316407:JW1394-MONOMER.

    Miscellaneous databases

    PROi P76086.

    Gene expression databases

    Genevestigatori P76086.

    Family and domain databases

    InterProi IPR012906. PaaX-like_N.
    IPR013225. PaaX_C.
    IPR011965. PaaX_trns_reg.
    [Graphical view ]
    Pfami PF07848. PaaX. 1 hit.
    PF08223. PaaX_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF020623. PaaX. 1 hit.
    TIGRFAMsi TIGR02277. PaaX_trns_reg. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway."
      Ferrandez A., Minambres B., Garcia B., Olivera E.R., Luengo J.M., Garcia J.L., Diaz E.
      J. Biol. Chem. 273:25974-25986(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN PHENYLACETATE CATABOLISM.
      Strain: W / ATCC 11105 / DSM 1900.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli."
      Ferrandez A., Garcia J.L., Diaz E.
      J. Biol. Chem. 275:12214-12222(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A TRANSCRIPTIONAL REPRESSOR, REGULATION BY PA-COA, CONSENSUS MOTIF.

    Entry informationi

    Entry nameiPAAX_ECOLI
    AccessioniPrimary (citable) accession number: P76086
    Secondary accession number(s): O53019, Q2MBC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3