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Protein

1,2-phenylacetyl-CoA epoxidase, subunit C

Gene

paaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit C may be essential for structural integrity of the alpha subunit.3 Publications

Pathwayi: phenylacetate degradation

This protein is involved in the pathway phenylacetate degradation, which is part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway phenylacetate degradation and in Aromatic compound metabolism.

GO - Biological processi

  • phenylacetate catabolic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6711-MONOMER.
ECOL316407:JW1385-MONOMER.
MetaCyc:G6711-MONOMER.
BRENDAi1.14.13.149. 2026.
UniPathwayiUPA00930.

Names & Taxonomyi

Protein namesi
Recommended name:
1,2-phenylacetyl-CoA epoxidase, subunit C
Alternative name(s):
1,2-phenylacetyl-CoA epoxidase, structural subunit beta
1,2-phenylacetyl-CoA monooxygenase, subunit C
Gene namesi
Name:paaC
Synonyms:ydbP
Ordered Locus Names:b1390, JW1385
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13737. paaC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581611 – 2481,2-phenylacetyl-CoA epoxidase, subunit CAdd BLAST248

Proteomic databases

PaxDbiP76079.
PRIDEiP76079.

Expressioni

Inductioni

Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX.2 Publications

Interactioni

Subunit structurei

Forms a stable heterotetramer (dimer of heterodimers) with PaaA and a stable heterodimer with PaaB.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
dpiAP0AEF44EBI-1131666,EBI-1119284

Protein-protein interaction databases

BioGridi4260175. 102 interactors.
IntActiP76079. 7 interactors.
STRINGi511145.b1390.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 23Combined sources22
Turni24 – 28Combined sources5
Beta strandi29 – 31Combined sources3
Helixi32 – 60Combined sources29
Helixi65 – 70Combined sources6
Helixi74 – 76Combined sources3
Helixi81 – 84Combined sources4
Helixi90 – 111Combined sources22
Helixi117 – 145Combined sources29
Helixi149 – 162Combined sources14
Helixi163 – 165Combined sources3
Helixi167 – 170Combined sources4
Helixi174 – 181Combined sources8
Helixi188 – 191Combined sources4
Helixi192 – 205Combined sources14
Helixi220 – 222Combined sources3
Helixi229 – 242Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OTKX-ray2.00A/B2-248[»]
3PVRX-ray2.10B/C2-248[»]
3PVTX-ray2.03B/C2-248[»]
3PVYX-ray2.15B/C2-248[»]
3PW1X-ray2.25B/C2-248[»]
3PW8X-ray2.97A/B2-248[»]
3PWQX-ray2.65A/B/E/G/I/J/K/R2-248[»]
4II4X-ray2.80B/C2-248[»]
ProteinModelPortaliP76079.
SMRiP76079.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76079.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 79Substrate bindingBy similarity4
Regioni177 – 179Substrate bindingBy similarity3

Phylogenomic databases

eggNOGiENOG4105D9S. Bacteria.
COG3396. LUCA.
HOGENOMiHOG000254959.
InParanoidiP76079.
KOiK02611.
OMAiAWCGHAP.
PhylomeDBiP76079.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR007814. PaaA_PaaC.
IPR011882. PaaC.
[Graphical view]
PfamiPF05138. PaaA_PaaC. 1 hit.
[Graphical view]
PIRSFiPIRSF037834. PA_CoA_Oase3. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR02158. PA_CoA_Oxy3. 1 hit.

Sequencei

Sequence statusi: Complete.

P76079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLTAYTLR LGDNCLVLSQ RLGEWCGHAP ELEIDLALAN IGLDLLGQAR
60 70 80 90 100
NFLSYAAELA GEGDEDTLAF TRDERQFSNL LLVEQPNGNF ADTIARQYFI
110 120 130 140 150
DAWHVALFTR LMESRDPQLA AISAKAIKEA RYHLRFSRGW LERLGNGTDV
160 170 180 190 200
SGQKMQQAIN KLWRFTAELF DADEIDIALS EEGIAVDPRT LRAAWEAEVF
210 220 230 240
AGINEATLNV PQEQAYRTGG KKGLHTEHLG PMLAEMQYLQ RVLPGQQW
Length:248
Mass (Da):27,877
Last modified:February 1, 1997 - v1
Checksum:i024AD161DF8E4380
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti160N → D in strain: W. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97452 Genomic DNA. Translation: CAA66092.1.
U00096 Genomic DNA. Translation: AAC74472.1.
AP009048 Genomic DNA. Translation: BAE76425.1.
PIRiA64890.
RefSeqiNP_415908.1. NC_000913.3.
WP_001072837.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74472; AAC74472; b1390.
BAE76425; BAE76425; BAE76425.
GeneIDi945956.
KEGGiecj:JW1385.
eco:b1390.
PATRICi32118066. VBIEscCol129921_1453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97452 Genomic DNA. Translation: CAA66092.1.
U00096 Genomic DNA. Translation: AAC74472.1.
AP009048 Genomic DNA. Translation: BAE76425.1.
PIRiA64890.
RefSeqiNP_415908.1. NC_000913.3.
WP_001072837.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OTKX-ray2.00A/B2-248[»]
3PVRX-ray2.10B/C2-248[»]
3PVTX-ray2.03B/C2-248[»]
3PVYX-ray2.15B/C2-248[»]
3PW1X-ray2.25B/C2-248[»]
3PW8X-ray2.97A/B2-248[»]
3PWQX-ray2.65A/B/E/G/I/J/K/R2-248[»]
4II4X-ray2.80B/C2-248[»]
ProteinModelPortaliP76079.
SMRiP76079.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260175. 102 interactors.
IntActiP76079. 7 interactors.
STRINGi511145.b1390.

Proteomic databases

PaxDbiP76079.
PRIDEiP76079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74472; AAC74472; b1390.
BAE76425; BAE76425; BAE76425.
GeneIDi945956.
KEGGiecj:JW1385.
eco:b1390.
PATRICi32118066. VBIEscCol129921_1453.

Organism-specific databases

EchoBASEiEB3500.
EcoGeneiEG13737. paaC.

Phylogenomic databases

eggNOGiENOG4105D9S. Bacteria.
COG3396. LUCA.
HOGENOMiHOG000254959.
InParanoidiP76079.
KOiK02611.
OMAiAWCGHAP.
PhylomeDBiP76079.

Enzyme and pathway databases

UniPathwayiUPA00930.
BioCyciEcoCyc:G6711-MONOMER.
ECOL316407:JW1385-MONOMER.
MetaCyc:G6711-MONOMER.
BRENDAi1.14.13.149. 2026.

Miscellaneous databases

EvolutionaryTraceiP76079.
PROiP76079.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR007814. PaaA_PaaC.
IPR011882. PaaC.
[Graphical view]
PfamiPF05138. PaaA_PaaC. 1 hit.
[Graphical view]
PIRSFiPIRSF037834. PA_CoA_Oase3. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR02158. PA_CoA_Oxy3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAAC_ECOLI
AccessioniPrimary (citable) accession number: P76079
Secondary accession number(s): O53011, Q2MBD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.