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Protein

1,2-phenylacetyl-CoA epoxidase, subunit B

Gene

paaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit B may play a regulatory role or be directly involved in electron transport.3 Publications

Pathwayi: phenylacetate degradation

This protein is involved in the pathway phenylacetate degradation, which is part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway phenylacetate degradation and in Aromatic compound metabolism.

GO - Biological processi

  • phenylacetate catabolic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6710-MONOMER.
ECOL316407:JW1384-MONOMER.
MetaCyc:G6710-MONOMER.
UniPathwayiUPA00930.

Names & Taxonomyi

Protein namesi
Recommended name:
1,2-phenylacetyl-CoA epoxidase, subunit B
Alternative name(s):
1,2-phenylacetyl-CoA monooxygenase, subunit B
Gene namesi
Name:paaB
Synonyms:ynbF
Ordered Locus Names:b1389, JW1384
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14299. paaB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 95951,2-phenylacetyl-CoA epoxidase, subunit BPRO_0000058160Add
BLAST

Proteomic databases

PaxDbiP76078.

Expressioni

Inductioni

Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX.2 Publications

Interactioni

Subunit structurei

Homotrimer. Forms a stable heterodimer with PaaC. Probably forms an oligomer with PaaAC.1 Publication

Protein-protein interaction databases

BioGridi4261630. 132 interactions.
IntActiP76078. 12 interactions.
STRINGi511145.b1389.

Structurei

3D structure databases

ProteinModelPortaliP76078.
SMRiP76078. Positions 4-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105N76. Bacteria.
COG3460. LUCA.
HOGENOMiHOG000249734.
InParanoidiP76078.
KOiK02610.
OMAiEWPLYEV.
PhylomeDBiP76078.

Family and domain databases

InterProiIPR009359. PaaB.
[Graphical view]
PfamiPF06243. PaaB. 1 hit.
[Graphical view]
PIRSFiPIRSF030200. PaaB. 1 hit.
TIGRFAMsiTIGR02157. PA_CoA_Oxy2. 1 hit.

Sequencei

Sequence statusi: Complete.

P76078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVYWPLYE VFVRGKQGLS HRHVGSLHAA DERMALENAR DAYTRRSEGC
60 70 80 90
SIWVVKASEI VASQPEERGE FFDPAESKVY RHPTFYTIPD GIEHM
Length:95
Mass (Da):10,942
Last modified:February 1, 1997 - v1
Checksum:iD2866DB428CF90AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97452 Genomic DNA. Translation: CAA66091.1.
U00096 Genomic DNA. Translation: AAC74471.1.
AP009048 Genomic DNA. Translation: BAE76424.1.
PIRiH64889.
RefSeqiNP_415907.1. NC_000913.3.
WP_000073393.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74471; AAC74471; b1389.
BAE76424; BAE76424; BAE76424.
GeneIDi947595.
KEGGiecj:JW1384.
eco:b1389.
PATRICi32118064. VBIEscCol129921_1452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97452 Genomic DNA. Translation: CAA66091.1.
U00096 Genomic DNA. Translation: AAC74471.1.
AP009048 Genomic DNA. Translation: BAE76424.1.
PIRiH64889.
RefSeqiNP_415907.1. NC_000913.3.
WP_000073393.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76078.
SMRiP76078. Positions 4-65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261630. 132 interactions.
IntActiP76078. 12 interactions.
STRINGi511145.b1389.

Proteomic databases

PaxDbiP76078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74471; AAC74471; b1389.
BAE76424; BAE76424; BAE76424.
GeneIDi947595.
KEGGiecj:JW1384.
eco:b1389.
PATRICi32118064. VBIEscCol129921_1452.

Organism-specific databases

EchoBASEiEB4046.
EcoGeneiEG14299. paaB.

Phylogenomic databases

eggNOGiENOG4105N76. Bacteria.
COG3460. LUCA.
HOGENOMiHOG000249734.
InParanoidiP76078.
KOiK02610.
OMAiEWPLYEV.
PhylomeDBiP76078.

Enzyme and pathway databases

UniPathwayiUPA00930.
BioCyciEcoCyc:G6710-MONOMER.
ECOL316407:JW1384-MONOMER.
MetaCyc:G6710-MONOMER.

Miscellaneous databases

PROiP76078.

Family and domain databases

InterProiIPR009359. PaaB.
[Graphical view]
PfamiPF06243. PaaB. 1 hit.
[Graphical view]
PIRSFiPIRSF030200. PaaB. 1 hit.
TIGRFAMsiTIGR02157. PA_CoA_Oxy2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAAB_ECOLI
AccessioniPrimary (citable) accession number: P76078
Secondary accession number(s): Q2MBD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.