P76056 (INTR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative lambdoid prophage Rac integrase

Gene names

Name:	intR
Synonyms:	ydaP
Ordered Locus Names:	b1345, JW1339

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome By similarity.
Sequence similarities	Belongs to the 'phage' integrase family.

Ontologies

Keywords
Biological process	DNA integration DNA recombination Initiation of viral infection Viral genome integration
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Putative lambdoid prophage Rac integrase		PRO_0000197517

Sequences

	Sequence		Length	Mass (Da)
	P76056 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E14B91630E0EF9A5	FASTA	411	47,539
	10 20 30 40 50 60 MSKLPTGVEI RGRYIRIWFM FRGKRCRETL KGWEITNSNI KKAGNLRALI VHEINSGEFE 70 80 90 100 110 120 YLRRFPQSST GAKMVTTRVI KTFGELCDIW TKIKETELTT NTMKKTKSQL KTLRIIICES 130 140 150 160 170 180 TPISHIRYSD ILNYRNELLH GETLYLDNPR SNKKGRTVRT VDNYIALLCS LLRFAYQSGF 190 200 210 220 230 240 ISTKPFEGVK KLQRNRIKPD PLSKTEFNAL MESEKGQSQN LWKFAVYSGL RHGELAALAW 250 260 270 280 290 300 EDVDLEKGIV NVRRNLTILD MFGPPKTNAG IRTVTLLQPA LEALKEQYKL TGHHRKSEIT 310 320 330 340 350 360 FYHREYGRTE KQKLHFVFMP RVCNGKQKPY YSVSSLGARW NAAVKRAGIR RRNPYHTRHT 370 380 390 400 410 FACWLLTAGA NPAFIASQMG HETAQMVYEI YGMWIDDMND EQIAMLNARL S

References

[1]

"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.

[2]

"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC74427.1. AP009048 Genomic DNA. Translation: BAE76408.1.
PIR	D64884.
RefSeq	NP_415861.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P76056.
ModBase	Search...
Protein-protein interaction databases
IntAct	P76056. 6 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000000028; EBESCP00000000028; EBESCG00000000022. EBESCT00000017032; EBESCP00000016323; EBESCG00000016091.
GeneID	946976.
GenomeReviews	Gene locus JW1339 in contig AP009048_GR. Gene locus b1345 in contig U00096_GR.
KEGG	ecj:JW1339. eco:b1345.
PATRIC	32117970. VBIEscCol129921_1405.
Organism-specific databases
EchoBASE	EB3141.
EcoGene	EG13358. intR.
Phylogenomic databases
eggNOG	COG0582.
GeneTree	EBGT00050000008626.
HOGENOM	HBG416319.
OMA	LIVHEIS.
PhylomeDB	P76056.
ProtClustDB	CLSK880096.
Enzyme and pathway databases
BioCyc	EcoCyc:G6676-MONOMER.
Gene expression databases
Genevestigator	P76056.
Family and domain databases
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core. IPR002104. Integrase_catalytic. IPR023109. Integrase_recombinase_N. IPR022000. Phage_p02_N. [Graphical view]
Gene3D	G3DSA:1.10.150.130. Integrase_recombinase_N. 1 hit. G3DSA:1.10.443.10. Phage_intgr_like. 1 hit.
KO	K14059.
Pfam	PF12167. DUF3596. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
SUPFAM	SSF56349. DNA_brk_join_enz. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INTR_ECOLI

Accession

Primary (citable) accession number: P76056
Secondary accession number(s): Q2MBE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program