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Protein

Prophage integrase IntR

Gene

intR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Enzyme and pathway databases

BioCyciEcoCyc:G6676-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prophage integrase IntRCurated
Alternative name(s):
Putative lambdoid prophage Rac integrase
Gene namesi
Name:intR
Synonyms:ydaP
Ordered Locus Names:b1345, JW1339
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13358 intR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975171 – 411Prophage integrase IntRAdd BLAST411

Proteomic databases

PaxDbiP76056
PRIDEiP76056

Interactioni

Protein-protein interaction databases

BioGridi4261947, 7 interactors
IntActiP76056, 6 interactors
STRINGi316385.ECDH10B_1466

Structurei

3D structure databases

ProteinModelPortaliP76056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Phylogenomic databases

eggNOGiENOG4107R08 Bacteria
COG0582 LUCA
HOGENOMiHOG000120142
InParanoidiP76056
KOiK14059
OMAiLWWDSYK
PhylomeDBiP76056

Family and domain databases

Gene3Di1.10.150.130, 1 hit
1.10.443.10, 1 hit
InterProiView protein in InterPro
IPR011010 DNA_brk_join_enz
IPR013762 Integrase-like_cat_sf
IPR002104 Integrase_catalytic
IPR010998 Integrase_recombinase_N
IPR022000 Min27-like_integrase_DNA_bind
PfamiView protein in Pfam
PF12167 Arm-DNA-bind_2, 1 hit
PF00589 Phage_integrase, 1 hit
SUPFAMiSSF56349 SSF56349, 1 hit

Sequencei

Sequence statusi: Complete.

P76056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLPTGVEI RGRYIRIWFM FRGKRCRETL KGWEITNSNI KKAGNLRALI
60 70 80 90 100
VHEINSGEFE YLRRFPQSST GAKMVTTRVI KTFGELCDIW TKIKETELTT
110 120 130 140 150
NTMKKTKSQL KTLRIIICES TPISHIRYSD ILNYRNELLH GETLYLDNPR
160 170 180 190 200
SNKKGRTVRT VDNYIALLCS LLRFAYQSGF ISTKPFEGVK KLQRNRIKPD
210 220 230 240 250
PLSKTEFNAL MESEKGQSQN LWKFAVYSGL RHGELAALAW EDVDLEKGIV
260 270 280 290 300
NVRRNLTILD MFGPPKTNAG IRTVTLLQPA LEALKEQYKL TGHHRKSEIT
310 320 330 340 350
FYHREYGRTE KQKLHFVFMP RVCNGKQKPY YSVSSLGARW NAAVKRAGIR
360 370 380 390 400
RRNPYHTRHT FACWLLTAGA NPAFIASQMG HETAQMVYEI YGMWIDDMND
410
EQIAMLNARL S
Length:411
Mass (Da):47,539
Last modified:February 1, 1997 - v1
Checksum:iE14B91630E0EF9A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74427.1
AP009048 Genomic DNA Translation: BAE76408.1
PIRiD64884
RefSeqiNP_415861.1, NC_000913.3
WP_000040852.1, NZ_CP014272.1

Genome annotation databases

EnsemblBacteriaiAAC74427; AAC74427; b1345
BAE76408; BAE76408; BAE76408
GeneIDi946976
KEGGiecj:JW1339
eco:b1345
PATRICifig|1411691.4.peg.931

Similar proteinsi

Entry informationi

Entry nameiINTR_ECOLI
AccessioniPrimary (citable) accession number: P76056
Secondary accession number(s): Q2MBE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health