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Protein

Probable DNA endonuclease SmrA

Gene

smrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has DNA endonuclease activity. Binds DNA.1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • endodeoxyribonuclease activity Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:G6672-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA endonuclease SmrA (EC:3.1.-.-)
Gene namesi
Name:smrA
Synonyms:ydaL
Ordered Locus Names:b1340, JW1334
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13354 smrA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001689061 – 187Probable DNA endonuclease SmrAAdd BLAST187

Proteomic databases

PaxDbiP76053
PRIDEiP76053

Interactioni

Protein-protein interaction databases

BioGridi4262880, 6 interactors
IntActiP76053, 1 interactor
STRINGi316385.ECDH10B_1461

Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi43 – 45Combined sources3
Beta strandi63 – 65Combined sources3
Turni71 – 74Combined sources4
Helixi75 – 78Combined sources4
Helixi84 – 86Combined sources3
Beta strandi87 – 89Combined sources3
Helixi95 – 111Combined sources17
Beta strandi115 – 120Combined sources6
Helixi130 – 143Combined sources14
Beta strandi148 – 153Combined sources6
Helixi156 – 158Combined sources3
Helixi160 – 162Combined sources3
Beta strandi163 – 168Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QD7X-ray2.30X39-175[»]
ProteinModelPortaliP76053
SMRiP76053
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76053

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 169SmrPROSITE-ProRule annotationAdd BLAST82

Phylogenomic databases

eggNOGiENOG4108DG9 Bacteria
COG2840 LUCA
HOGENOMiHOG000257489
InParanoidiP76053
OMAiMIKSHVN
PhylomeDBiP76053

Family and domain databases

InterProiView protein in InterPro
IPR002625 Smr_dom
IPR036063 Smr_dom_sf
PfamiView protein in Pfam
PF01713 Smr, 1 hit
SMARTiView protein in SMART
SM00463 SMR, 1 hit
SUPFAMiSSF160443 SSF160443, 1 hit
PROSITEiView protein in PROSITE
PS50828 SMR, 1 hit

Sequencei

Sequence statusi: Complete.

P76053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLDDKSLFL DAMEDVQPLK RATDVHWHPT RNQRAPQRID TLQLDNFLTT
60 70 80 90 100
GFLDIIPLSQ PLEFRREGLQ HGVLDKLRSG KYPQQASLNL LRQPVEECRK
110 120 130 140 150
MVFSFIQQAL ADGLRNVLII HGKGRDDKSH ANIVRSYVAR WLTEFDDVQA
160 170 180
YCTALPHHGG SGACYVALRK TAQAKQENWE RHAKRSR
Length:187
Mass (Da):21,512
Last modified:February 1, 1997 - v1
Checksum:i5FC4F67116D92129
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40D → E AA sequence (PubMed:21276852).Curated1
Sequence conflicti45D → E AA sequence (PubMed:21276852).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74422.1
AP009048 Genomic DNA Translation: BAE76405.1
PIRiG64883
RefSeqiNP_415856.1, NC_000913.3
WP_001046829.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74422; AAC74422; b1340
BAE76405; BAE76405; BAE76405
GeneIDi945953
KEGGiecj:JW1334
eco:b1340
PATRICifig|1411691.4.peg.937

Similar proteinsi

Entry informationi

Entry nameiSMRA_ECOLI
AccessioniPrimary (citable) accession number: P76053
Secondary accession number(s): Q2MBF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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