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Protein

K(+)/H(+) antiporter NhaP2

Gene

cvrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

K+/H+ antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By similarity). Participates in control of cell volume in low-osmolarity conditions.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell volume homeostasis Source: EcoCyc
  • regulation of potassium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciEcoCyc:YCGO-MONOMER.
ECOL316407:JW5184-MONOMER.

Protein family/group databases

TCDBi2.A.36.6.11. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
K(+)/H(+) antiporter NhaP2UniRule annotation
Alternative name(s):
Potassium/proton antiporter NhaP2UniRule annotation
Gene namesi
Name:cvrA
Synonyms:nhaP2, ycgO
Ordered Locus Names:b1191, JW5184
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13896. cvrA.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei30 – 5021HelicalUniRule annotationAdd
BLAST
Transmembranei58 – 7821HelicalUniRule annotationAdd
BLAST
Transmembranei87 – 10721HelicalUniRule annotationAdd
BLAST
Transmembranei119 – 14123HelicalUniRule annotationAdd
BLAST
Transmembranei156 – 17621HelicalUniRule annotationAdd
BLAST
Transmembranei183 – 20321HelicalUniRule annotationAdd
BLAST
Transmembranei216 – 23621HelicalUniRule annotationAdd
BLAST
Transmembranei237 – 25721HelicalUniRule annotationAdd
BLAST
Transmembranei270 – 29021HelicalUniRule annotationAdd
BLAST
Transmembranei293 – 31321HelicalUniRule annotationAdd
BLAST
Transmembranei334 – 35421HelicalUniRule annotationAdd
BLAST
Transmembranei363 – 38321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: UniProtKB-HAMAP
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578K(+)/H(+) antiporter NhaP2PRO_0000052381Add
BLAST

Proteomic databases

PaxDbiP76007.
PRIDEiP76007.

Interactioni

Protein-protein interaction databases

BioGridi4261367. 11 interactions.
IntActiP76007. 1 interaction.
STRINGi511145.b1191.

Structurei

3D structure databases

ProteinModelPortaliP76007.
SMRiP76007. Positions 15-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini403 – 48583RCK C-terminalUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. [View classification]UniRule annotation
Contains 1 RCK C-terminal domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3N. Bacteria.
COG3263. LUCA.
HOGENOMiHOG000019567.
InParanoidiP76007.
KOiK11105.
OMAiFRFNWRE.
PhylomeDBiP76007.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
3.30.70.1450. 1 hit.
HAMAPiMF_01075. NhaP2. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR030151. NhaP.
IPR023729. NhaP2.
IPR006037. RCK_C.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PANTHERiPTHR32507:SF7. PTHR32507:SF7. 1 hit.
PfamiPF03471. CorC_HlyC. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
PF02080. TrkA_C. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATTIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGV
60 70 80 90 100
GGIPFDNYPF AYMVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV
110 120 130 140 150
LITSGLTGMM AAWLFNLDLI EGLLIGAIVG STDAAAVFSL LGGKGLNERV
160 170 180 190 200
GSTLEIESGS NDPMAVFLTI TLIAMIQHHE SNISWMFIVD ILQQFGLGIV
210 220 230 240 250
IGLGGGYLLL QMINRIALPA GLYPLLALSG GILIFSLTTA LEGSGILAVY
260 270 280 290 300
LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV NPSDLLPIAI
310 320 330 340 350
PALILSAWMI FFARPLSVFA GLLPFRGFNL RERVFISWVG LRGAVPIILA
360 370 380 390 400
VFPMMAGLEN ARLFFNVAFF VVLVSLLLQG TSLSWAAKKA KVVVPPVGRP
410 420 430 440 450
VSRVGLDIHP ENPWEQFVYQ LSADKWCVGA ALRDLHMPKE TRIAALFRDN
460 470 480 490 500
QLLHPTGSTR LREGDVLCVI GRERDLPALG KLFSQSPPVA LDQRFFGDFI
510 520 530 540 550
LEASAKYADV ALIYGLEDGR EYRDKQQTLG EIVQQLLGAA PVVGDQVEFA
560 570
GMIWTVAEKE DNEVLKIGVR VAEEEAES
Length:578
Mass (Da):62,285
Last modified:July 15, 1999 - v2
Checksum:i4637F874E527334A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74275.2.
AP009048 Genomic DNA. Translation: BAA36046.2.
PIRiD64865.
RefSeqiNP_415709.2. NC_000913.3.
WP_000340194.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74275; AAC74275; b1191.
BAA36046; BAA36046; BAA36046.
GeneIDi945755.
KEGGiecj:JW5184.
eco:b1191.
PATRICi32117630. VBIEscCol129921_1237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74275.2.
AP009048 Genomic DNA. Translation: BAA36046.2.
PIRiD64865.
RefSeqiNP_415709.2. NC_000913.3.
WP_000340194.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76007.
SMRiP76007. Positions 15-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261367. 11 interactions.
IntActiP76007. 1 interaction.
STRINGi511145.b1191.

Protein family/group databases

TCDBi2.A.36.6.11. the monovalent cation:proton antiporter-1 (cpa1) family.

Proteomic databases

PaxDbiP76007.
PRIDEiP76007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74275; AAC74275; b1191.
BAA36046; BAA36046; BAA36046.
GeneIDi945755.
KEGGiecj:JW5184.
eco:b1191.
PATRICi32117630. VBIEscCol129921_1237.

Organism-specific databases

EchoBASEiEB3655.
EcoGeneiEG13896. cvrA.

Phylogenomic databases

eggNOGiENOG4105C3N. Bacteria.
COG3263. LUCA.
HOGENOMiHOG000019567.
InParanoidiP76007.
KOiK11105.
OMAiFRFNWRE.
PhylomeDBiP76007.

Enzyme and pathway databases

BioCyciEcoCyc:YCGO-MONOMER.
ECOL316407:JW5184-MONOMER.

Miscellaneous databases

PROiP76007.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
3.30.70.1450. 1 hit.
HAMAPiMF_01075. NhaP2. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR030151. NhaP.
IPR023729. NhaP2.
IPR006037. RCK_C.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PANTHERiPTHR32507:SF7. PTHR32507:SF7. 1 hit.
PfamiPF03471. CorC_HlyC. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
PF02080. TrkA_C. 1 hit.
[Graphical view]
SMARTiSM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF116726. SSF116726. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51202. RCK_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNHAP2_ECOLI
AccessioniPrimary (citable) accession number: P76007
Secondary accession number(s): O07654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: September 7, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.