Skip Header

Contribute Send feedback
Read comments (?) or add your own

P76007 (CVRA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell volume regulation protein A
Gene names
Name:cvrA
Synonyms:ycgO
Ordered Locus Names:b1191, JW5184
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length578 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in control of cell volume in low-osmolarity conditions. Ref.4

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01075.

Sequence similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. CvrA subfamily. [View classification]

Contains 1 RCK C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 578578Cell volume regulation protein A HAMAP-Rule MF_01075
PRO_0000052381

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane30 – 5021Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane119 – 14123Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane293 – 31321Helical; Potential
Transmembrane334 – 35421Helical; Potential
Transmembrane363 – 38321Helical; Potential
Domain403 – 48583RCK C-terminal

Sequences

Sequence LengthMass (Da)Tools
P76007 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 4637F874E527334A

FASTA57862,285
        10         20         30         40         50         60 
MDATTIISLF ILGSILVTSS ILLSSFSSRL GIPILVIFLA IGMLAGVDGV GGIPFDNYPF 

        70         80         90        100        110        120 
AYMVSNLALA IILLDGGMRT QASSFRVALG PALSLATLGV LITSGLTGMM AAWLFNLDLI 

       130        140        150        160        170        180 
EGLLIGAIVG STDAAAVFSL LGGKGLNERV GSTLEIESGS NDPMAVFLTI TLIAMIQHHE 

       190        200        210        220        230        240 
SNISWMFIVD ILQQFGLGIV IGLGGGYLLL QMINRIALPA GLYPLLALSG GILIFSLTTA 

       250        260        270        280        290        300 
LEGSGILAVY LCGFLLGNRP IRNRYGILQN FDGLAWLAQI AMFLVLGLLV NPSDLLPIAI 

       310        320        330        340        350        360 
PALILSAWMI FFARPLSVFA GLLPFRGFNL RERVFISWVG LRGAVPIILA VFPMMAGLEN 

       370        380        390        400        410        420 
ARLFFNVAFF VVLVSLLLQG TSLSWAAKKA KVVVPPVGRP VSRVGLDIHP ENPWEQFVYQ 

       430        440        450        460        470        480 
LSADKWCVGA ALRDLHMPKE TRIAALFRDN QLLHPTGSTR LREGDVLCVI GRERDLPALG 

       490        500        510        520        530        540 
KLFSQSPPVA LDQRFFGDFI LEASAKYADV ALIYGLEDGR EYRDKQQTLG EIVQQLLGAA 

       550        560        570 
PVVGDQVEFA GMIWTVAEKE DNEVLKIGVR VAEEEAES

« Hide

References

« Hide 'large scale' references
[1]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Deletion of one of two Escherichia coli genes encoding putative Na+/H+ exchangers (ycgO) perturbs cytoplasmic alkali cation balance at low osmolarity."
Verkhovskaya M.L., Barquera B., Wikstroem M.
Microbiology 147:3005-3013(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: GR70N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00096 Genomic DNA. Translation: AAC74275.2.
AP009048 Genomic DNA. Translation: BAA36046.2.
PIRD64865.
RefSeqNP_415709.2. NC_000913.2.
YP_489458.1. NC_007779.1.

3D structure databases

ProteinModelPortalP76007.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b1191.

Proteomic databases

PaxDbP76007.
PRIDEP76007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74275; AAC74275; b1191.
BAA36046; BAA36046; BAA36046.
GeneID12932373.
945755.
KEGGecj:Y75_p1163.
eco:b1191.
PATRIC32117630. VBIEscCol129921_1237.

Organism-specific databases

EchoBASEEB3655.
EcoGeneEG13896. cvrA.

Phylogenomic databases

eggNOGCOG3263.
HOGENOMHOG000019567.
KOK11105.
OMASEWELFV.
ProtClustDBPRK05326.

Enzyme and pathway databases

BioCycEcoCyc:YCGO-MONOMER.
ECOL316407:JW5184-MONOMER.

Gene expression databases

GenevestigatorP76007.

Family and domain databases

Gene3D3.30.465.10. 1 hit.
HAMAPMF_01075. CvrA.
InterProIPR006153. Cation/H_exchanger.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR023729. CvrA.
IPR006037. RCK_C.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamPF03471. CorC_HlyC. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
PF02080. TrkA_C. 1 hit.
[Graphical view]
SMARTSM01091. CorC_HlyC. 1 hit.
[Graphical view]
PROSITEPS51202. RCK_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCVRA_ECOLI
AccessionPrimary (citable) accession number: P76007
Secondary accession number(s): O07654
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents