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Protein

Probable cyclic di-GMP phosphodiesterase PdeG

Gene

pdeG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.By similarity

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Ligandc-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:G6608-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cyclic di-GMP phosphodiesterase PdeGCurated (EC:3.1.4.52By similarity)
Gene namesi
Name:pdeG1 Publication
Synonyms:ycgG
Ordered Locus Names:b1168, JW5174
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13888 ycgG

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001688531 – 507Probable cyclic di-GMP phosphodiesterase PdeGAdd BLAST507

Proteomic databases

PaxDbiP75995
PRIDEiP75995

Expressioni

Inductioni

Induced by 0.3 M NaCl in an RpoS-dependent fashion.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261455, 14 interactors
DIPiDIP-11554N
IntActiP75995, 1 interactor
STRINGi316385.ECDH10B_1217

Structurei

3D structure databases

ProteinModelPortaliP75995
SMRiP75995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 500EALPROSITE-ProRule annotationAdd BLAST255

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
HOGENOMiHOG000273106
InParanoidiP75995
OMAiDKQMRNT
PhylomeDBiP75995

Family and domain databases

CDDicd01948 EAL, 1 hit
Gene3Di3.20.20.450, 1 hit
InterProiView protein in InterPro
IPR024744 CSS-motif_dom
IPR001633 EAL_dom
IPR035919 EAL_sf
PfamiView protein in Pfam
PF12792 CSS-motif, 1 hit
PF00563 EAL, 1 hit
SMARTiView protein in SMART
SM00052 EAL, 1 hit
SUPFAMiSSF141868 SSF141868, 1 hit
PROSITEiView protein in PROSITE
PS50883 EAL, 1 hit

Sequencei

Sequence statusi: Complete.

P75995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNTLIPILV AICLFITGVA ILNIQLWYSA KAEYLAGARY AANNINHILE
60 70 80 90 100
EASQATQTAV NIAGKECNLE EQYQLGTEAA LKPHLRTIII LKQGIVWCTS
110 120 130 140 150
LPGNRVLLSR IPVFPDSNLL LAPAIDTVNR LPILLYQNQF ADTRILVTIS
160 170 180 190 200
DQHIRGALNV PLKGVRYVLR VADDIIGPTG DVMTLNGHYP YTEKVHSTKY
210 220 230 240 250
HFTIIFNPPP LFSFYRLIDK GFGILIFILL IACAAAFLLD RYFNKSATPE
260 270 280 290 300
EILRRAINNG EIVPFYQPVV NGREGTLRGV EVLARWKQPH GGYISPAAFI
310 320 330 340 350
PLAEKSGLIV PLTQSLMNQV ARQMNAIASK LPEGFHIGIN FSASHIISPT
360 370 380 390 400
FVDECLNFRD SFTRRDLNLV LEVTEREPLN VDESLVQRLN ILHENGFVIA
410 420 430 440 450
LDDFGTGYSG LSYLHDLHID YIKIDHSFVG RVNADPESTR ILDCVLDLAR
460 470 480 490 500
KLSISIVAEG VETKEQLDYL NQNYITFQQG YYFYKPVTYI DLVKIILSKP

KVKVVVE
Length:507
Mass (Da):56,906
Last modified:April 27, 2001 - v2
Checksum:iD144600B361285D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74252.2
AP009048 Genomic DNA Translation: BAA36000.2
PIRiE64862
RefSeqiNP_415686.2, NC_000913.3
WP_001246499.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74252; AAC74252; b1168
BAA36000; BAA36000; BAA36000
GeneIDi945738
KEGGiecj:JW5174
eco:b1168
PATRICifig|1411691.4.peg.1123

Similar proteinsi

Entry informationi

Entry nameiPDEG_ECOLI
AccessioniPrimary (citable) accession number: P75995
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: April 25, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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