Reviewed, UniProtKB/Swiss-Prot P75989 (YCGE_ECOLI)

Names and origin

Protein names

Recommended name:
    Uncharacterized HTH-type transcriptional regulator ycgE

Gene names

Name:	ycgE
Ordered Locus Names:	b1162, JW1149

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 HTH merR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
hipA	P23874	1	EBI-560582,EBI-560590
lpdA	P0A9P0	1	EBI-560582,EBI-542856

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Uncharacterized HTH-type transcriptional regulator ycgE		PRO_0000098165
Regions
	Domain	3 – 72	70	HTH merR-type
	DNA binding	6 – 25	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P75989-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E8E5AD376A18EB84	FASTA	243	28,265
	10 20 30 40 50 60 MAYYSIGDVA ERCGINPVTL RAWQRRYGLL KPQRSEGGHR LFDEEDIQRI EEIKRWISNG 70 80 90 100 110 120 VPVGKVKALL ETTSQDTEDD WSRLQEEMMS ILRMANPAKL RARIISLGRE YPVDQLINHV 130 140 150 160 170 180 YLPVRQRLVL DHNTSRIMSS MFDGALIEYA ATSLFEMRRK PGKEAILMAW NVEERARLWL 190 200 210 220 230 240 EAWRLSLSGW HISVLADPIE SPRPELFPTQ TLIVWTGMAP TRRQNELLQH WGEQGYKVIF HAP

References

[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00096 Genomic DNA. Translation: AAC74246.1. AP009048 Genomic DNA. Translation: BAA35997.1.
PIR	G64861.
RefSeq	AP_001787.1. NP_415680.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:11552N.
IntAct	P75989. 39 interactions.
Genome annotation databases
GeneID	945735.
GenomeReviews	Gene locus JW1149 in contig AP009048_GR. Gene locus b1162 in contig U00096_GR.
KEGG	ecj:JW1149. eco:b1162.
Organism-specific databases
EchoBASE	EB3645.
EcoGene	EG13886. ycgE.
CMR	Search...
Phylogenomic databases
HOGENOM	P75989.
OMA	P75989. IREIQGW.
Enzyme and pathway databases
BioCyc	EcoCyc:G6602-MON.
Family and domain databases
InterPro	IPR000551. HTH_MerR. [Graphical view]
Pfam	PF00376. MerR. 1 hit. [Graphical view]
SMART	SM00422. HTH_MERR. 1 hit. [Graphical view]
PROSITE	PS00552. HTH_MERR_1. 1 hit. PS50937. HTH_MERR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YCGE_ECOLI

Accession

Primary (citable) accession number: P75989
Secondary accession number(s): Q9R7N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)