Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anti-adapter protein IraM

Gene

iraM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation. May also be involved in the early steps of isoprenoid biosynthesis, possibly through its role as RssB regulator.1 Publication

GO - Molecular functioni

  • anti-sigma factor antagonist activity Source: EcoCyc

GO - Biological processi

  • cellular response to acidic pH Source: EcoCyc
  • cellular response to magnesium starvation Source: EcoCyc
  • negative regulation of protein catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:G6600-MONOMER.
ECOL316407:JW1147-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-adapter protein IraM
Alternative name(s):
Enhancing lycopene biosynthesis protein 1
Gene namesi
Name:iraM
Synonyms:elb1, elbA, ycgW
Ordered Locus Names:b1160, JW1147
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13885. elbA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Anti-adapter protein IraMPRO_0000086951Add
BLAST

Proteomic databases

PaxDbiP75987.

Expressioni

Inductioni

By magnesium and calcium starvation, via the transcriptional regulator PhoP.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262861. 12 interactions.
IntActiP75987. 1 interaction.
STRINGi511145.b1160.

Structurei

3D structure databases

ProteinModelPortaliP75987.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IraM/RssC family.Curated

Phylogenomic databases

eggNOGiENOG41066T8. Bacteria.
ENOG41125KS. LUCA.
HOGENOMiHOG000050886.
OMAiFSAIWGD.
OrthoDBiEOG6PS5X2.

Family and domain databases

HAMAPiMF_01199. Anti_adapt_IraM.
InterProiIPR014448. Anti-adapter_IraM.
[Graphical view]
PIRSFiPIRSF007036. Elb1. 1 hit.

Sequencei

Sequence statusi: Complete.

P75987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWIVIDTVI QPTCGISFSA IWGNMKMIIW YQSTIFLPPG SIFTPVKSGI
60 70 80 90 100
ILKDKEYPIT IYHIAPFNKD LWSLLKSSQE CPPGESKITN KCLHNSCIIK

ICPYGLK
Length:107
Mass (Da):12,133
Last modified:February 1, 1997 - v1
Checksum:i27F8A8C64FA18984
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74244.1.
AP009048 Genomic DNA. Translation: BAE76383.1.
PIRiE64861.
RefSeqiNP_415678.1. NC_000913.3.
WP_001295666.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74244; AAC74244; b1160.
BAE76383; BAE76383; BAE76383.
GeneIDi945729.
KEGGiecj:JW1147.
eco:b1160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74244.1.
AP009048 Genomic DNA. Translation: BAE76383.1.
PIRiE64861.
RefSeqiNP_415678.1. NC_000913.3.
WP_001295666.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75987.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262861. 12 interactions.
IntActiP75987. 1 interaction.
STRINGi511145.b1160.

Proteomic databases

PaxDbiP75987.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74244; AAC74244; b1160.
BAE76383; BAE76383; BAE76383.
GeneIDi945729.
KEGGiecj:JW1147.
eco:b1160.

Organism-specific databases

EchoBASEiEB3644.
EcoGeneiEG13885. elbA.

Phylogenomic databases

eggNOGiENOG41066T8. Bacteria.
ENOG41125KS. LUCA.
HOGENOMiHOG000050886.
OMAiFSAIWGD.
OrthoDBiEOG6PS5X2.

Enzyme and pathway databases

BioCyciEcoCyc:G6600-MONOMER.
ECOL316407:JW1147-MONOMER.

Miscellaneous databases

PROiP75987.

Family and domain databases

HAMAPiMF_01199. Anti_adapt_IraM.
InterProiIPR014448. Anti-adapter_IraM.
[Graphical view]
PIRSFiPIRSF007036. Elb1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: candidates for early genes in isoprenoid biosynthesis."
    Hemmi H., Ohnuma S., Nagaoka K., Nishino T.
    J. Biochem. 123:1088-1096(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION.
  4. "Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach."
    Yang H., Wolff E., Kim M., Diep A., Miller J.H.
    Mol. Microbiol. 53:283-295(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTATOR PHENOTYPE.
  5. "Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors."
    Bougdour A., Cunning C., Baptiste P.J., Elliott T., Gottesman S.
    Mol. Microbiol. 68:298-313(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN THE STABILIZATION OF RPOS, INDUCTION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiIRAM_ECOLI
AccessioniPrimary (citable) accession number: P75987
Secondary accession number(s): Q2MBH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.