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Protein

Lipoprotein-releasing system transmembrane protein LolE

Gene

lolE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.

GO - Molecular functioni

GO - Biological processi

  • lipoprotein localization to outer membrane Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YCFW-MONOMER

Protein family/group databases

TCDBi3.A.1.125.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein-releasing system transmembrane protein LolE
Gene namesi
Name:lolE
Synonyms:ycfW
Ordered Locus Names:b1118, JW1104
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13441 lolE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
  • plasma membrane protein complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002018182 – 414Lipoprotein-releasing system transmembrane protein LolEAdd BLAST413

Proteomic databases

PaxDbiP75958
PRIDEiP75958

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
palP0A9122EBI-1125190,EBI-1124760

Protein-protein interaction databases

BioGridi4262905349 interactors.
IntActiP75958 7 interactors.
MINTiP75958
STRINGi316385.ECDH10B_1190

Structurei

3D structure databases

ProteinModelPortaliP75958
SMRiP75958
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D60 Bacteria
COG4591 LUCA
HOGENOMiHOG000218040
InParanoidiP75958
KOiK09808
OMAiERTQMIG
PhylomeDBiP75958

Family and domain databases

InterProiView protein in InterPro
IPR003838 ABC_permease_dom
IPR011926 LolC/E_gammaproteobact
IPR011925 LolCE_TM
IPR025857 MacB_PCD
PfamiView protein in Pfam
PF02687 FtsX, 1 hit
PF12704 MacB_PCD, 1 hit
TIGRFAMsiTIGR02212 lolCE, 1 hit
TIGR02213 lolE_release, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMPLSLLIG LRFSRGRRRG GMVSLISVIS TIGIALGVAV LIVGLSAMNG
60 70 80 90 100
FERELNNRIL AVVPHGEIEA VDQPWTNWQE ALDHVQKVPG IAAAAPYINF
110 120 130 140 150
TGLVESGANL RAIQVKGVNP QQEQRLSALP SFVQGDAWRN FKAGEQQIII
160 170 180 190 200
GKGVADALKV KQGDWVSIMI PNSNPEHKLM QPKRVRLHVA GILQLSGQLD
210 220 230 240 250
HSFAMIPLAD AQQYLDMGSS VSGIALKMTD VFNANKLVRD AGEVTNSYVY
260 270 280 290 300
IKSWIGTYGY MYRDIQMIRA IMYLAMVLVI GVACFNIVST LVMAVKDKSG
310 320 330 340 350
DIAVLRTLGA KDGLIRAIFV WYGLLAGLFG SLCGVIIGVV VSLQLTPIIE
360 370 380 390 400
WIEKLIGHQF LSSDIYFIDF LPSELHWLDV FYVLVTALLL SLLASWYPAR
410
RASNIDPARV LSGQ
Length:414
Mass (Da):45,344
Last modified:January 23, 2007 - v3
Checksum:i37B73A6E5DC58517
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74202.1
AP009048 Genomic DNA Translation: BAA35938.1
PIRiC64856
RefSeqiNP_415636.1, NC_000913.3
WP_001251348.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74202; AAC74202; b1118
BAA35938; BAA35938; BAA35938
GeneIDi945665
KEGGiecj:JW1104
eco:b1118
PATRICifig|511145.12.peg.1164

Similar proteinsi

Entry informationi

Entry nameiLOLE_ECOLI
AccessioniPrimary (citable) accession number: P75958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome