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Protein

Lipoprotein-releasing system transmembrane protein LolE

Gene

lolE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA.

GO - Molecular functioni

  • lipoprotein transporter activity Source: EcoCyc

GO - Biological processi

  • lipoprotein transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YCFW-MONOMER.
ECOL316407:JW1104-MONOMER.

Protein family/group databases

TCDBi3.A.1.125.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein-releasing system transmembrane protein LolE
Gene namesi
Name:lolE
Synonyms:ycfW
Ordered Locus Names:b1118, JW1104
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13441. lolE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Gram-negative-bacterium-type cell wall Source: InterPro
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
  • protein complex Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 414413Lipoprotein-releasing system transmembrane protein LolEPRO_0000201818Add
BLAST

Proteomic databases

PaxDbiP75958.
PRIDEiP75958.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
palP0A9122EBI-1125190,EBI-1124760

Protein-protein interaction databases

BioGridi4262905. 328 interactions.
IntActiP75958. 7 interactions.
MINTiMINT-8401583.
STRINGi511145.b1118.

Structurei

3D structure databases

ProteinModelPortaliP75958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D60. Bacteria.
COG4591. LUCA.
HOGENOMiHOG000218040.
InParanoidiP75958.
KOiK09808.
OMAiLNDYPQM.
PhylomeDBiP75958.

Family and domain databases

InterProiIPR003838. ABC_permease_dom.
IPR011926. LolC/E_gammaproteobact.
IPR011925. LolCE_TM.
IPR025857. MacB_PCD.
[Graphical view]
PfamiPF02687. FtsX. 1 hit.
PF12704. MacB_PCD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02212. lolCE. 1 hit.
TIGR02213. lolE_release. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMPLSLLIG LRFSRGRRRG GMVSLISVIS TIGIALGVAV LIVGLSAMNG
60 70 80 90 100
FERELNNRIL AVVPHGEIEA VDQPWTNWQE ALDHVQKVPG IAAAAPYINF
110 120 130 140 150
TGLVESGANL RAIQVKGVNP QQEQRLSALP SFVQGDAWRN FKAGEQQIII
160 170 180 190 200
GKGVADALKV KQGDWVSIMI PNSNPEHKLM QPKRVRLHVA GILQLSGQLD
210 220 230 240 250
HSFAMIPLAD AQQYLDMGSS VSGIALKMTD VFNANKLVRD AGEVTNSYVY
260 270 280 290 300
IKSWIGTYGY MYRDIQMIRA IMYLAMVLVI GVACFNIVST LVMAVKDKSG
310 320 330 340 350
DIAVLRTLGA KDGLIRAIFV WYGLLAGLFG SLCGVIIGVV VSLQLTPIIE
360 370 380 390 400
WIEKLIGHQF LSSDIYFIDF LPSELHWLDV FYVLVTALLL SLLASWYPAR
410
RASNIDPARV LSGQ
Length:414
Mass (Da):45,344
Last modified:January 23, 2007 - v3
Checksum:i37B73A6E5DC58517
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74202.1.
AP009048 Genomic DNA. Translation: BAA35938.1.
PIRiC64856.
RefSeqiNP_415636.1. NC_000913.3.
WP_001251348.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74202; AAC74202; b1118.
BAA35938; BAA35938; BAA35938.
GeneIDi945665.
KEGGiecj:JW1104.
eco:b1118.
PATRICi32117483. VBIEscCol129921_1164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74202.1.
AP009048 Genomic DNA. Translation: BAA35938.1.
PIRiC64856.
RefSeqiNP_415636.1. NC_000913.3.
WP_001251348.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262905. 328 interactions.
IntActiP75958. 7 interactions.
MINTiMINT-8401583.
STRINGi511145.b1118.

Protein family/group databases

TCDBi3.A.1.125.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP75958.
PRIDEiP75958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74202; AAC74202; b1118.
BAA35938; BAA35938; BAA35938.
GeneIDi945665.
KEGGiecj:JW1104.
eco:b1118.
PATRICi32117483. VBIEscCol129921_1164.

Organism-specific databases

EchoBASEiEB3215.
EcoGeneiEG13441. lolE.

Phylogenomic databases

eggNOGiENOG4105D60. Bacteria.
COG4591. LUCA.
HOGENOMiHOG000218040.
InParanoidiP75958.
KOiK09808.
OMAiLNDYPQM.
PhylomeDBiP75958.

Enzyme and pathway databases

BioCyciEcoCyc:YCFW-MONOMER.
ECOL316407:JW1104-MONOMER.

Miscellaneous databases

PROiP75958.

Family and domain databases

InterProiIPR003838. ABC_permease_dom.
IPR011926. LolC/E_gammaproteobact.
IPR011925. LolCE_TM.
IPR025857. MacB_PCD.
[Graphical view]
PfamiPF02687. FtsX. 1 hit.
PF12704. MacB_PCD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02212. lolCE. 1 hit.
TIGR02213. lolE_release. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLOLE_ECOLI
AccessioniPrimary (citable) accession number: P75958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.