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Protein

HTH-type transcriptional repressor ComR

Gene

comR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.1 Publication

Enzyme regulationi

Binding to the promoter region of BhsA/ComC is released in the presence of copper.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi41 – 60H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to copper ion Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandCopper

Enzyme and pathway databases

BioCyciEcoCyc:G6569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor ComR
Alternative name(s):
Copper outer membrane regulator
Gene namesi
Name:comR
Synonyms:ycfQ
Ordered Locus Names:b1111, JW5159
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13435. comR.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Deletion mutants contain lower cytoplasmic copper levels compared to the wild-type strain when exposed to copper.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000706381 – 210HTH-type transcriptional repressor ComRAdd BLAST210

Proteomic databases

PaxDbiP75952.
PRIDEiP75952.

Interactioni

Protein-protein interaction databases

BioGridi4260995. 6 interactors.
STRINGi511145.b1111.

Structurei

3D structure databases

ProteinModelPortaliP75952.
SMRiP75952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 78HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4108IND. Bacteria.
ENOG41122NH. LUCA.
HOGENOMiHOG000161265.
InParanoidiP75952.
OMAiMAVQATN.
PhylomeDBiP75952.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS50977. HTH_TETR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P75952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDSTQCVK KSRGRPKVFD RDAALDKAMK LFWQHGYEAT SLADLVEATG
60 70 80 90 100
AKAPTLYAEF TNKEGLFRAV LDRYIDRFAA KHEAQLFCEE KSVESALADY
110 120 130 140 150
FAAIANCFTS KDTPAGCFMI NNCTTLSPDS GDIANTLKSR HAMQERTLQQ
160 170 180 190 200
FLCQRQARGE IPPHCDVTHL AEFLNCIIQG MSISAREGAS LEKLMQIAGT
210
TLRLWPELVK
Length:210
Mass (Da):23,362
Last modified:December 15, 1998 - v2
Checksum:i8C1D523668756E42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74195.2.
AP009048 Genomic DNA. Translation: BAA35926.2.
RefSeqiNP_415629.4. NC_000913.3.
WP_001336528.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74195; AAC74195; b1111.
BAA35926; BAA35926; BAA35926.
GeneIDi947425.
KEGGiecj:JW5159.
eco:b1111.
PATRICi32117465. VBIEscCol129921_1155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74195.2.
AP009048 Genomic DNA. Translation: BAA35926.2.
RefSeqiNP_415629.4. NC_000913.3.
WP_001336528.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75952.
SMRiP75952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260995. 6 interactors.
STRINGi511145.b1111.

Proteomic databases

PaxDbiP75952.
PRIDEiP75952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74195; AAC74195; b1111.
BAA35926; BAA35926; BAA35926.
GeneIDi947425.
KEGGiecj:JW5159.
eco:b1111.
PATRICi32117465. VBIEscCol129921_1155.

Organism-specific databases

EchoBASEiEB3209.
EcoGeneiEG13435. comR.

Phylogenomic databases

eggNOGiENOG4108IND. Bacteria.
ENOG41122NH. LUCA.
HOGENOMiHOG000161265.
InParanoidiP75952.
OMAiMAVQATN.
PhylomeDBiP75952.

Enzyme and pathway databases

BioCyciEcoCyc:G6569-MONOMER.

Miscellaneous databases

PROiPR:P75952.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS50977. HTH_TETR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOMR_ECOLI
AccessioniPrimary (citable) accession number: P75952
Secondary accession number(s): Q9R7N8, Q9R7N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: May 10, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.