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Protein

HTH-type transcriptional repressor ComR

Gene

comR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.1 Publication

Enzyme regulationi

Binding to the promoter region of BhsA/ComC is released in the presence of copper.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi41 – 60H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • response to copper ion Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandCopper

Enzyme and pathway databases

BioCyciEcoCyc:G6569-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor ComR
Alternative name(s):
Copper outer membrane regulator
Gene namesi
Name:comR
Synonyms:ycfQ
Ordered Locus Names:b1111, JW5159
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13435 comR

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Deletion mutants contain lower cytoplasmic copper levels compared to the wild-type strain when exposed to copper.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000706381 – 210HTH-type transcriptional repressor ComRAdd BLAST210

Proteomic databases

PaxDbiP75952
PRIDEiP75952

Interactioni

Protein-protein interaction databases

BioGridi4260995, 6 interactors
STRINGi316385.ECDH10B_1183

Structurei

3D structure databases

ProteinModelPortaliP75952
SMRiP75952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 78HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4108IND Bacteria
ENOG41122NH LUCA
HOGENOMiHOG000161265
InParanoidiP75952
KOiK22041
OMAiMAVQATN
PhylomeDBiP75952

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P75952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDSTQCVK KSRGRPKVFD RDAALDKAMK LFWQHGYEAT SLADLVEATG
60 70 80 90 100
AKAPTLYAEF TNKEGLFRAV LDRYIDRFAA KHEAQLFCEE KSVESALADY
110 120 130 140 150
FAAIANCFTS KDTPAGCFMI NNCTTLSPDS GDIANTLKSR HAMQERTLQQ
160 170 180 190 200
FLCQRQARGE IPPHCDVTHL AEFLNCIIQG MSISAREGAS LEKLMQIAGT
210
TLRLWPELVK
Length:210
Mass (Da):23,362
Last modified:December 15, 1998 - v2
Checksum:i8C1D523668756E42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74195.2
AP009048 Genomic DNA Translation: BAA35926.2
RefSeqiNP_415629.4, NC_000913.3
WP_001336528.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74195; AAC74195; b1111
BAA35926; BAA35926; BAA35926
GeneIDi947425
KEGGiecj:JW5159
eco:b1111
PATRICifig|511145.12.peg.1155

Similar proteinsi

Entry informationi

Entry nameiCOMR_ECOLI
AccessioniPrimary (citable) accession number: P75952
Secondary accession number(s): Q9R7N8, Q9R7N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health