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Protein

Thiamine kinase

Gene

thiK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of thiamine to thiamine phosphate.

Catalytic activityi

ATP + thiamine = ADP + thiamine phosphate.

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine phosphate from thiamine.
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamine kinase (thiK)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine phosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • thiamine kinase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:THIKIN-MONOMER
MetaCyc:THIKIN-MONOMER
UniPathwayiUPA00060; UER00596

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine kinase (EC:2.7.1.89)
Gene namesi
Name:thiK
Synonyms:ycfN
Ordered Locus Names:b1106, JW1092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13432 thiK

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002180571 – 274Thiamine kinaseAdd BLAST274

Proteomic databases

PaxDbiP75948
PRIDEiP75948

Interactioni

Protein-protein interaction databases

BioGridi4260073, 122 interactors
IntActiP75948, 5 interactors
STRINGi316385.ECDH10B_1178

Structurei

3D structure databases

ProteinModelPortaliP75948
SMRiP75948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiamine kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108RUM Bacteria
COG0510 LUCA
HOGENOMiHOG000219316
KOiK07251
OMAiDVHAGNI

Family and domain databases

HAMAPiMF_01604 Thiamine_kinase, 1 hit
InterProiView protein in InterPro
IPR002575 Aminoglycoside_PTrfase
IPR011009 Kinase-like_dom_sf
IPR014093 Thiamine_kinase
PfamiView protein in Pfam
PF01636 APH, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
TIGRFAMsiTIGR02721 ycfN_thiK, 1 hit

Sequencei

Sequence statusi: Complete.

P75948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFRSNNPIT RDELLSRFFP QYHPVTTFNS GLSGGSFLIE HQGQRFVVRQ
60 70 80 90 100
PHDPDAPQSA FLRQYRALSQ LPACIAPKPH LYLRDWMVVD YLPGAVKTYL
110 120 130 140 150
PDTNELAGLL YYLHQQPRFG WRITLLPLLE LYWQQSDPAR RTVGWLRMLK
160 170 180 190 200
RLRKAREPRP LRLSPLHMDV HAGNLVHSAS GLKLIDWEYA GDGDIALELA
210 220 230 240 250
AVWVENTEQH RQLVNDYATR AKIYPAQLWR QVRRWFPWLL MLKAGWFEYR
260 270
WRQTGDQQFI RLADDTWRQL LIKQ
Length:274
Mass (Da):32,397
Last modified:February 1, 1997 - v1
Checksum:i0F4DBC46F43944CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74190.1
AP009048 Genomic DNA Translation: BAA35913.1
PIRiG64854
RefSeqiNP_415624.1, NC_000913.3
WP_001116592.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74190; AAC74190; b1106
BAA35913; BAA35913; BAA35913
GeneIDi948525
KEGGiecj:JW1092
eco:b1106
PATRICifig|1411691.4.peg.1161

Similar proteinsi

Entry informationi

Entry nameiTHIK_ECOLI
AccessioniPrimary (citable) accession number: P75948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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