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P75942

- FLGJ_ECOLI

UniProt

P75942 - FLGJ_ECOLI

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Protein
Peptidoglycan hydrolase FlgJ
Gene
flgJ, fla FX, flaZ, b1081, JW1068
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei220 – 2201 Reviewed prediction
Active sitei245 – 2451 Reviewed prediction

GO - Molecular functioni

  1. amidase activity Source: InterPro
  2. hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW

GO - Biological processi

  1. bacterial-type flagellum assembly Source: InterPro
  2. bacterial-type flagellum-dependent cell motility Source: InterPro
  3. cell wall macromolecule metabolic process Source: InterPro
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Bacterial flagellum biogenesis, Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciEcoCyc:G366-MONOMER.
ECOL316407:JW1068-MONOMER.

Protein family/group databases

CAZyiGH73. Glycoside Hydrolase Family 73.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan hydrolase FlgJ (EC:3.2.1.-)
Alternative name(s):
Muramidase FlgJ
Gene namesi
Name:flgJ
Synonyms:fla FX, flaZ
Ordered Locus Names:b1081, JW1068
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG14272. flgJ.

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. bacterial-type flagellum Source: InterPro
  2. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Peptidoglycan hydrolase FlgJ
PRO_0000165705Add
BLAST

Proteomic databases

PRIDEiP75942.

Expressioni

Gene expression databases

GenevestigatoriP75942.

Interactioni

Protein-protein interaction databases

IntActiP75942. 11 interactions.
STRINGi511145.b1081.

Structurei

3D structure databases

ProteinModelPortaliP75942.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 313166Catalytic
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the FlgJ family.
In the C-terminal section; belongs to the glycosyl hydrolase 73 family.

Phylogenomic databases

eggNOGiCOG3951.
HOGENOMiHOG000265620.
KOiK02395.
OMAiMLFKSMR.
OrthoDBiEOG6KQ6M6.

Family and domain databases

InterProiIPR019301. Flagellar_prot_FlgJ_N.
IPR013377. FlaJ.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view]
PfamiPF01832. Glucosaminidase. 1 hit.
PF10135. Rod-binding. 1 hit.
[Graphical view]
SMARTiSM00047. LYZ2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02541. flagell_FlgJ. 1 hit.

Sequencei

Sequence statusi: Complete.

P75942-1 [UniParc]FASTAAdd to Basket

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MISDSKLLAS AAWDAQSLNE LKAKAGEDPA ANIRPVARQV EGMFVQMMLK    50
SMRDALPKDG LFSSEHTRLY TSMYDQQIAQ QMTAGKGLGL AEMMVKQMTP 100
EQPLPEESTP AAPMKFPLET VVRYQNQALS QLVQKAVPRN YDDSLPGDSK 150
AFLAQLSLPA QLASQQSGVP HHLILAQAAL ESGWGQRQIR RENGEPSYNL 200
FGVKASGNWK GPVTEITTTE YENGEAKKVK AKFRVYSSYL EALSDYVGLL 250
TRNPRYAAVT TAASAEQGAQ ALQDAGYATD PHYARKLTNM IQQMKSISDK 300
VSKTYSMNID NLF 313
Length:313
Mass (Da):34,475
Last modified:February 1, 1997 - v1
Checksum:iC4B3CB8F36751CDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74165.1.
AP009048 Genomic DNA. Translation: BAA35890.1.
PIRiF64851.
RefSeqiNP_415599.1. NC_000913.3.
YP_489349.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74165; AAC74165; b1081.
BAA35890; BAA35890; BAA35890.
GeneIDi12932026.
947456.
KEGGiecj:Y75_p1051.
eco:b1081.
PATRICi32117403. VBIEscCol129921_1124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC74165.1 .
AP009048 Genomic DNA. Translation: BAA35890.1 .
PIRi F64851.
RefSeqi NP_415599.1. NC_000913.3.
YP_489349.1. NC_007779.1.

3D structure databases

ProteinModelPortali P75942.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75942. 11 interactions.
STRINGi 511145.b1081.

Protein family/group databases

CAZyi GH73. Glycoside Hydrolase Family 73.

Proteomic databases

PRIDEi P75942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74165 ; AAC74165 ; b1081 .
BAA35890 ; BAA35890 ; BAA35890 .
GeneIDi 12932026.
947456.
KEGGi ecj:Y75_p1051.
eco:b1081.
PATRICi 32117403. VBIEscCol129921_1124.

Organism-specific databases

EchoBASEi EB4020.
EcoGenei EG14272. flgJ.

Phylogenomic databases

eggNOGi COG3951.
HOGENOMi HOG000265620.
KOi K02395.
OMAi MLFKSMR.
OrthoDBi EOG6KQ6M6.

Enzyme and pathway databases

BioCyci EcoCyc:G366-MONOMER.
ECOL316407:JW1068-MONOMER.

Miscellaneous databases

PROi P75942.

Gene expression databases

Genevestigatori P75942.

Family and domain databases

InterProi IPR019301. Flagellar_prot_FlgJ_N.
IPR013377. FlaJ.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view ]
Pfami PF01832. Glucosaminidase. 1 hit.
PF10135. Rod-binding. 1 hit.
[Graphical view ]
SMARTi SM00047. LYZ2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02541. flagell_FlgJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiFLGJ_ECOLI
AccessioniPrimary (citable) accession number: P75942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably exported via the flagellum-specific export pathway.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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