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Protein

Glucans biosynthesis protein C

Gene

mdoC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.

Pathwayi: osmoregulated periplasmic glucan (OPG) biosynthesis

This protein is involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway osmoregulated periplasmic glucan (OPG) biosynthesis and in Glycan metabolism.

GO - Molecular functioni

  • succinyltransferase activity Source: EcoCyc
  • transferase activity, transferring one-carbon groups Source: UniProtKB-HAMAP

GO - Biological processi

  • glucan biosynthetic process Source: UniProtKB-HAMAP
  • oligosaccharide metabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:G6552-MONOMER.
ECOL316407:JW1034-MONOMER.
UniPathwayiUPA00637.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucans biosynthesis protein C (EC:2.1.-.-)
Gene namesi
Name:mdoC
Synonyms:opgC, ymdD
Ordered Locus Names:b1047, JW1034
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13876. mdoC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Transmembranei338 – 35821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Glucans biosynthesis protein CPRO_0000218049Add
BLAST

Proteomic databases

PaxDbiP75920.
PRIDEiP75920.

Interactioni

Protein-protein interaction databases

BioGridi4260688. 280 interactions.
STRINGi511145.b1047.

Structurei

3D structure databases

ProteinModelPortaliP75920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EIK. Bacteria.
ENOG410ZVNJ. LUCA.
HOGENOMiHOG000219329.
InParanoidiP75920.
KOiK11941.
OMAiYFSYMLY.

Family and domain databases

HAMAPiMF_01066. MdoC_OpgC. 1 hit.
InterProiIPR002656. Acyl_transf_3.
IPR023723. Glucans_biosynth_C.
[Graphical view]
PfamiPF01757. Acyl_transf_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVPAQREY FLDSIRAWLM LLGIPFHISL IYSSHTWHVN SAESSLWLTL
60 70 80 90 100
FNDFIHSFRM QVFFVISGYF SYMLFLRYPL KKWWKVRVER VGIPMLTAIP
110 120 130 140 150
LLTLPQFIML QYVKGKAESW PGLSLYDKYN TLAWELISHL WFLLVLVVMT
160 170 180 190 200
TLCVWIFKRI RNNLENSDKT NKKFSMVKLS VIFLCLGIGY AVIRRTIFIV
210 220 230 240 250
YPPILSNGMF NFIVMQTLFY LPFFILGALA FIFPHLKALF TTPSRGCTLA
260 270 280 290 300
AALAFVAYLL NQRYGSGDAW MYETESVITM VLGLWMVNVV FSFGHRLLNF
310 320 330 340 350
QSARVTYFVN ASLFIYLVHH PLTLFFGAYI TPHITSNWLG FLCGLIFVVG
360 370 380
IAIILYEIHL RIPLLKFLFS GKPVVKREND KAPAR
Length:385
Mass (Da):44,690
Last modified:February 1, 1997 - v1
Checksum:i24B869CE8E0224DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74131.1.
AP009048 Genomic DNA. Translation: BAA35837.1.
PIRiD64847.
RefSeqiNP_415565.1. NC_000913.3.
WP_001070375.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74131; AAC74131; b1047.
BAA35837; BAA35837; BAA35837.
GeneIDi946944.
KEGGiecj:JW1034.
eco:b1047.
PATRICi32117331. VBIEscCol129921_1088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74131.1.
AP009048 Genomic DNA. Translation: BAA35837.1.
PIRiD64847.
RefSeqiNP_415565.1. NC_000913.3.
WP_001070375.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260688. 280 interactions.
STRINGi511145.b1047.

Proteomic databases

PaxDbiP75920.
PRIDEiP75920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74131; AAC74131; b1047.
BAA35837; BAA35837; BAA35837.
GeneIDi946944.
KEGGiecj:JW1034.
eco:b1047.
PATRICi32117331. VBIEscCol129921_1088.

Organism-specific databases

EchoBASEiEB3635.
EcoGeneiEG13876. mdoC.

Phylogenomic databases

eggNOGiENOG4105EIK. Bacteria.
ENOG410ZVNJ. LUCA.
HOGENOMiHOG000219329.
InParanoidiP75920.
KOiK11941.
OMAiYFSYMLY.

Enzyme and pathway databases

UniPathwayiUPA00637.
BioCyciEcoCyc:G6552-MONOMER.
ECOL316407:JW1034-MONOMER.

Miscellaneous databases

PROiP75920.

Family and domain databases

HAMAPiMF_01066. MdoC_OpgC. 1 hit.
InterProiIPR002656. Acyl_transf_3.
IPR023723. Glucans_biosynth_C.
[Graphical view]
PfamiPF01757. Acyl_transf_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPGC_ECOLI
AccessioniPrimary (citable) accession number: P75920
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.