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Protein

Cardiolipin synthase C

Gene

clsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).1 Publication

Miscellaneous

All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase.1 Publication

Catalytic activityi

Phosphatidylglycerol + phosphatidylethanolamine = diphosphatidylglycerol + ethanolamine.UniRule annotation1 Publication

Enzyme regulationi

Full activity requires coexpression with the neighboring gene ymdB.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130UniRule annotation1
Active sitei132UniRule annotation1
Active sitei137UniRule annotation1
Active sitei369UniRule annotation1
Active sitei371UniRule annotation1
Active sitei376UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cardiolipin biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:G6551-MONOMER
MetaCyc:G6551-MONOMER
BRENDAi2.7.8.B11 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase CUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsC1 PublicationUniRule annotation
Synonyms:ymdC
Ordered Locus Names:b1046, JW5150
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13875 clsC

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Triple deletion of clsA, clsB and clsC results in a complete lack of cardiolipin, regardless of growth phase or growth conditions.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi130H → A: Lack of activity. 1 Publication1
Mutagenesisi369H → A: Lack of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012891 – 473Cardiolipin synthase CAdd BLAST473

Proteomic databases

PaxDbiP75919
PRIDEiP75919

Interactioni

Protein-protein interaction databases

BioGridi4260689, 12 interactors
DIPiDIP-12712N
IntActiP75919, 1 interactor
STRINGi316385.ECDH10B_1118

Structurei

3D structure databases

ProteinModelPortaliP75919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 152PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini364 – 391PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107RZC Bacteria
COG1502 LUCA
HOGENOMiHOG000157571
InParanoidiP75919
KOiK06132
OMAiANRRMHN
PhylomeDBiP75919

Family and domain databases

HAMAPiMF_01918 Cardiolipin_synth_ClsC, 1 hit
InterProiView protein in InterPro
IPR030871 Cardiolipin_synth_ClsC
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

P75919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLASAVLP LCSQHPGQCG LFPLEKSLDA FAARYRLAEM AEHTLDVQYY
60 70 80 90 100
IWQDDMSGRL LFSALLAAAK RGVRVRLLLD DNNTPGLDDI LRLLDSHPRI
110 120 130 140 150
EVRLFNPFSF RLLRPLGYIT DFSRLNRRMH NKSFTVDGVV TLVGGRNIGD
160 170 180 190 200
AYFGAGEEPL FSDLDVMAIG PVVEDVADDF ARYWYCKSVS PLQQVLDVPE
210 220 230 240 250
GEMADRIELP ASWHNDAMTH RYLRKMESSP FINHLVDGTL PLIWAKTRLL
260 270 280 290 300
SDDPAKGEGK AKRHSLLPQR LFDIMGSPSE RIDIISSYFV PTRAGVAQLL
310 320 330 340 350
RMVRKGVKIA ILTNSLAAND VAVVHAGYAR WRKKLLRYGV ELYELKPTRE
360 370 380 390 400
QSSTLHDRGI TGNSGASLHA KTFSIDGKTV FIGSFNFDPR STLLNTEMGF
410 420 430 440 450
VIESETLAQL IDKRFIQSQY DAAWQLRLDR WGRINWVDRH AKKEIILKKE
460 470
PATSFWKRVM VRLASILPVE WLL
Length:473
Mass (Da):53,666
Last modified:November 13, 2007 - v2
Checksum:iC98F856D1FD00CD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74130.2
AP009048 Genomic DNA Translation: BAA35836.2
PIRiC64847
RefSeqiNP_415564.2, NC_000913.3
WP_001299031.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74130; AAC74130; b1046
BAA35836; BAA35836; BAA35836
GeneIDi947321
KEGGiecj:JW5150
eco:b1046
PATRICifig|511145.12.peg.1087

Similar proteinsi

Entry informationi

Entry nameiCLSC_ECOLI
AccessioniPrimary (citable) accession number: P75919
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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