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Protein

Putative inactive ferrous iron permease EfeU

Gene

efeU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

  • ferrous iron uptake transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ferrous iron transport Source: EcoCyc
  • high-affinity iron ion transmembrane transport Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6525-MONOMER.

Protein family/group databases

TCDBi2.A.108.2.3. the iron/lead transporter (ilt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive ferrous iron permease EfeU
Alternative name(s):
Putative Fe(2+) ion permease EfeU
Gene namesi
Name:efeU
Synonyms:ycdN
Ordered Locus Names:b4490, JW5141/JW1002
ORF Names:b1016/b1017
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13860. efeU.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11PeriplasmicSequence analysis
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Topological domaini23 – 3513CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Topological domaini57 – 6913PeriplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 11828CytoplasmicSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 1478PeriplasmicSequence analysis
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 17911CytoplasmicSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Topological domaini201 – 24444PeriplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 27611CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Putative inactive ferrous iron permease EfeUPRO_0000159652Add
BLAST

Interactioni

Subunit structurei

Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB. However, this EfeUOB tripartite iron transporter is defective in E.coli strain K12 due to a frameshift mutation in EfeU.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP75901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000236918.
InParanoidiP75901.
PhylomeDBiP75901.

Family and domain databases

InterProiIPR005217. FTR1-like.
IPR004923. FTR1/Fip1/EfeU.
[Graphical view]
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiPF03239. FTR1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00145. TIGR00145. 1 hit.

Sequencei

Sequence statusi: Complete.

P75901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVPFLIMLR EGLEAALIVS LIASYLKRTQ RGMXDCVMWI GVLLAAALCL
60 70 80 90 100
GLGIFINETT GEFPQKEQEL FEGIVAVIAV VILTWMVFWM RKVSRNVKVQ
110 120 130 140 150
LEQAVDSALQ RGNHHGWALV MMVFFAVARE GLESVFFLLA AFQQDVGIWP
160 170 180 190 200
PLGAMLGLAT AVVLGFLLYW GGIRLNLGAF FKWTSLFILF VAAGLAAGAI
210 220 230 240 250
RAFHEAGLWN HFQEIAFDMS AVLSTHSLFG TLMEGIFGYQ EAPSVSEVAV
260 270
WFIYLIPALV AFALPPRAGA TASRSA
Length:276
Mass (Da):30,292
Last modified:December 15, 1998 - v2
Checksum:i27FC648B7F791AE7
GO

Sequence cautioni

The sequence AP009048 differs from that shown. Reason: Frameshift at position 34. Curated
The sequence U00096 differs from that shown. Reason: Frameshift at position 34. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliP75901.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.108.2.3. the iron/lead transporter (ilt) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EchoBASEiEB3620.
EcoGeneiEG13860. efeU.

Phylogenomic databases

HOGENOMiHOG000236918.
InParanoidiP75901.
PhylomeDBiP75901.

Enzyme and pathway databases

BioCyciEcoCyc:G6525-MONOMER.

Family and domain databases

InterProiIPR005217. FTR1-like.
IPR004923. FTR1/Fip1/EfeU.
[Graphical view]
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiPF03239. FTR1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00145. TIGR00145. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7."
    Cao J., Woodhall M.R., Alvarez J., Cartron M.L., Andrews S.C.
    Mol. Microbiol. 65:857-875(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LACK OF ACTIVITY IN STRAIN K12.
    Strain: K12.

Entry informationi

Entry nameiEFEU_ECOLI
AccessioniPrimary (citable) accession number: P75901
Secondary accession number(s): P75900, Q9R3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. Strain K12 contains a truncated, inactive permease due to a frameshift in position 34 that produces two separate ORFs. The sequence shown here is a reconstruction originating from EcoGene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.