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Protein

Threonine-rich inner membrane protein GfcA

Gene

gfcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:G6508-MONOMER.
ECOL316407:JW5133-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine-rich inner membrane protein GfcA
Alternative name(s):
Group 4 capsule protein A homolog
Gene namesi
Name:gfcA
Synonyms:ymcD
Ordered Locus Names:b0987, JW5133
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13732. gfcA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 5938CytoplasmicSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 10121PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 10180Threonine-rich inner membrane protein GfcAPRO_0000168799Add
BLAST

Proteomic databases

PaxDbiP75885.

Interactioni

Protein-protein interaction databases

BioGridi4262044. 9 interactions.
DIPiDIP-12710N.
IntActiP75885. 1 interaction.
STRINGi511145.b0987.

Structurei

3D structure databases

ProteinModelPortaliP75885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 10086Thr-richAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000009401.
OMAiKRKVMKH.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHKLSAILM AFMLTTPAAF AAPEATNGTE ATTGTTGTTT TTTGATTTAT
60 70 80 90 100
TTGGVAAGAV GTATVVGVAT AVGVATLAVV AANDSGDGGS HNTSTTTSTT

R
Length:101
Mass (Da):9,508
Last modified:November 13, 2007 - v2
Checksum:iAE3E86C5E6166C83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74072.2.
AP009048 Genomic DNA. Translation: BAA35752.1.
PIRiA64840.
RefSeqiNP_415507.2. NC_000913.3.
WP_001295358.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74072; AAC74072; b0987.
BAA35752; BAA35752; BAA35752.
GeneIDi945029.
KEGGiecj:JW5133.
eco:b0987.
PATRICi32117197. VBIEscCol129921_1022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74072.2.
AP009048 Genomic DNA. Translation: BAA35752.1.
PIRiA64840.
RefSeqiNP_415507.2. NC_000913.3.
WP_001295358.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262044. 9 interactions.
DIPiDIP-12710N.
IntActiP75885. 1 interaction.
STRINGi511145.b0987.

Proteomic databases

PaxDbiP75885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74072; AAC74072; b0987.
BAA35752; BAA35752; BAA35752.
GeneIDi945029.
KEGGiecj:JW5133.
eco:b0987.
PATRICi32117197. VBIEscCol129921_1022.

Organism-specific databases

EchoBASEiEB3496.
EcoGeneiEG13732. gfcA.

Phylogenomic databases

HOGENOMiHOG000009401.
OMAiKRKVMKH.

Enzyme and pathway databases

BioCyciEcoCyc:G6508-MONOMER.
ECOL316407:JW5133-MONOMER.

Miscellaneous databases

PROiP75885.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiGFCA_ECOLI
AccessioniPrimary (citable) accession number: P75885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 13, 2007
Last modified: January 20, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.