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Protein

Putative Lon protease homolog

Gene

ycbZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei438By similarity1
Active sitei481By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciEcoCyc:G6493-MONOMER.
ECOL316407:JW0938-MONOMER.

Protein family/group databases

MEROPSiS16.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Lon protease homolog (EC:3.4.21.-)
Alternative name(s):
ATP-dependent protease La homolog
Gene namesi
Name:ycbZ
Ordered Locus Names:b0955, JW0938
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13718. ycbZ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761481 – 586Putative Lon protease homologAdd BLAST586

Proteomic databases

PaxDbiP75867.
PRIDEiP75867.

Interactioni

Protein-protein interaction databases

BioGridi4260030. 9 interactors.
DIPiDIP-11487N.
STRINGi511145.b0955.

Structurei

3D structure databases

ProteinModelPortaliP75867.
SMRiP75867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini346 – 543Lon proteolyticPROSITE-ProRule annotationAdd BLAST198

Domaini

Lacks the ATP-binding domain.

Sequence similaritiesi

Belongs to the peptidase S16 family.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DAN. Bacteria.
COG1067. LUCA.
HOGENOMiHOG000277817.
InParanoidiP75867.
KOiK04770.
OMAiGFFTICQ.
PhylomeDBiP75867.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiIPR027065. Lon_Prtase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF05362. Lon_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITKLAWRD LVPDTDSYQE IFAQPHLIDE NDPLFSDTQP RLQFALEQLL
60 70 80 90 100
HTRASSSFML AKAPEESEYL NLIANAARTL QSDAGQLVGG HYEVSGHSIR
110 120 130 140 150
LRHAVSADDN FATLTQVVAA DWVEAEQLFG CLRQFNGDIT LQPGLVHQAN
160 170 180 190 200
GGILIISLRT LLAQPLLWMR LKNIVNRERF DWVAFDESRP LPVSVPSMPL
210 220 230 240 250
KLKVILVGER ESLADFQEME PELSEQAIYS EFEDTLQIVD AESVTQWCRW
260 270 280 290 300
VTFTARHNHL PAPGADAWPI LIREAARYTG EQETLPLSPQ WILRQCKEVA
310 320 330 340 350
SLCDGDTFSG EQLNLMLQQR EWREGFLAER MQDEILQEQI LIETEGERIG
360 370 380 390 400
QINALSVIEF PGHPRAFGEP SRISCVVHIG DGEFTDIERK AELGGNIHAK
410 420 430 440 450
GMMIMQAFLM SELQLEQQIP FSASLTFEQS YSEVDGDSAS MAELCALISA
460 470 480 490 500
LADVPVNQSI AITGSVDQFG RAQPVGGLNE KIEGFFAICQ QRELTGKQGV
510 520 530 540 550
IIPTANVRHL SLHSELVKAV EEGKFTIWAV DDVTDALPLL LNLVWDGEGQ
560 570 580
TTLMQTIQER IAQASQQEGR HRFPWPLRWL NWFIPN
Length:586
Mass (Da):65,819
Last modified:February 1, 1997 - v1
Checksum:i442AAEADDB87B59F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74041.1.
AP009048 Genomic DNA. Translation: BAA35713.1.
PIRiB64836.
RefSeqiNP_415475.1. NC_000913.3.
WP_000156518.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74041; AAC74041; b0955.
BAA35713; BAA35713; BAA35713.
GeneIDi945569.
KEGGiecj:JW0938.
eco:b0955.
PATRICi32117129. VBIEscCol129921_0989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74041.1.
AP009048 Genomic DNA. Translation: BAA35713.1.
PIRiB64836.
RefSeqiNP_415475.1. NC_000913.3.
WP_000156518.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75867.
SMRiP75867.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260030. 9 interactors.
DIPiDIP-11487N.
STRINGi511145.b0955.

Protein family/group databases

MEROPSiS16.A10.

Proteomic databases

PaxDbiP75867.
PRIDEiP75867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74041; AAC74041; b0955.
BAA35713; BAA35713; BAA35713.
GeneIDi945569.
KEGGiecj:JW0938.
eco:b0955.
PATRICi32117129. VBIEscCol129921_0989.

Organism-specific databases

EchoBASEiEB3482.
EcoGeneiEG13718. ycbZ.

Phylogenomic databases

eggNOGiENOG4105DAN. Bacteria.
COG1067. LUCA.
HOGENOMiHOG000277817.
InParanoidiP75867.
KOiK04770.
OMAiGFFTICQ.
PhylomeDBiP75867.

Enzyme and pathway databases

BioCyciEcoCyc:G6493-MONOMER.
ECOL316407:JW0938-MONOMER.

Miscellaneous databases

PROiP75867.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiIPR027065. Lon_Prtase.
IPR008269. Pept_S16_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF05362. Lon_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS51786. LON_PROTEOLYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLONH_ECOLI
AccessioniPrimary (citable) accession number: P75867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.