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Protein

Cell division protein ZapC

Gene

zapC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.UniRule annotation2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • regulation of cell division Source: EcoliWiki

Keywordsi

Biological processCell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:G6486-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZapCUniRule annotation
Alternative name(s):
FtsZ-associated protein C
Z-ring-associated protein C
Gene namesi
Name:zapCUniRule annotation
Synonyms:ycbW
Ordered Locus Names:b0946, JW5125
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13715 zapC

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants divide almost normally under standard growth conditions.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22L → P: Does not interact with FtsZ, but shows affinity for itself. Reduces GTPase activity by less than 10%. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687781 – 180Cell division protein ZapCAdd BLAST180

Proteomic databases

PaxDbiP75862
PRIDEiP75862

Interactioni

Subunit structurei

Interacts directly with FtsZ. Monomer in solution.UniRule annotation2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259444, 7 interactors
DIPiDIP-11485N
IntActiP75862, 22 interactors
MINTiP75862
STRINGi316385.ECDH10B_1016

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Turni15 – 18Combined sources4
Beta strandi19 – 23Combined sources5
Beta strandi25 – 27Combined sources3
Beta strandi29 – 31Combined sources3
Helixi36 – 38Combined sources3
Helixi41 – 44Combined sources4
Helixi51 – 64Combined sources14
Beta strandi67 – 69Combined sources3
Helixi71 – 87Combined sources17
Beta strandi112 – 117Combined sources6
Turni118 – 120Combined sources3
Beta strandi123 – 131Combined sources9
Beta strandi133 – 140Combined sources8
Beta strandi142 – 147Combined sources6
Beta strandi150 – 153Combined sources4
Beta strandi157 – 161Combined sources5
Helixi162 – 164Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E1LX-ray2.15A1-180[»]
5FO3X-ray2.90A/B1-180[»]
ProteinModelPortaliP75862
SMRiP75862
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZapC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108T7E Bacteria
ENOG410YF51 LUCA
HOGENOMiHOG000277864
KOiK18657
OMAiIKVMNDR

Family and domain databases

HAMAPiMF_00906 ZapC, 1 hit
InterProiView protein in InterPro
IPR009809 ZapC
PfamiView protein in Pfam
PF07126 ZapC, 1 hit
PIRSFiPIRSF010252 ZapC, 1 hit

Sequencei

Sequence statusi: Complete.

P75862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKPDDNWR WYYDEEHDRM MLDLANGMLF RSRFARKMLT PDAFSPAGFC
60 70 80 90 100
VDDAALYFSF EEKCRDFNLS KEQKAELVLN ALVAIRYLKP QMPKSWHFVS
110 120 130 140 150
HGEMWVPMPG DAACVWLSDT HEQVNLLVVE SGENAALCLL AQPCVVIAGR
160 170 180
AMQLGDAIKI MNDRLKPQVN VDSFSLEQAV
Length:180
Mass (Da):20,589
Last modified:December 1, 2000 - v2
Checksum:i7A8CC66ECE2D1B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74032.2
AP009048 Genomic DNA Translation: BAA35701.2
PIRiA64835
RefSeqiNP_415466.4, NC_000913.3
WP_001295353.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74032; AAC74032; b0946
BAA35701; BAA35701; BAA35701
GeneIDi945552
KEGGiecj:JW5125
eco:b0946
PATRICifig|1411691.4.peg.1328

Similar proteinsi

Entry informationi

Entry nameiZAPC_ECOLI
AccessioniPrimary (citable) accession number: P75862
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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