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Protein

Cell division protein ZapC

Gene

zapC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.UniRule annotation2 Publications

GO - Biological processi

  • cell septum assembly Source: UniProtKB-HAMAP
  • FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  • regulation of cell division Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:G6486-MONOMER.
ECOL316407:JW5125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZapCUniRule annotation
Alternative name(s):
FtsZ-associated protein C
Z-ring-associated protein C
Gene namesi
Name:zapCUniRule annotation
Synonyms:ycbW
Ordered Locus Names:b0946, JW5125
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13715. zapC.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants divide almost normally under standard growth conditions.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22L → P: Does not interact with FtsZ, but shows affinity for itself. Reduces GTPase activity by less than 10%. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687781 – 180Cell division protein ZapCAdd BLAST180

Proteomic databases

PaxDbiP75862.
PRIDEiP75862.

Interactioni

Subunit structurei

Interacts directly with FtsZ. Monomer in solution.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-552519,EBI-552519
ftsZP0A9A65EBI-552519,EBI-370963

Protein-protein interaction databases

BioGridi4259444. 7 interactors.
DIPiDIP-11485N.
IntActiP75862. 22 interactors.
MINTiMINT-1227819.
STRINGi511145.b0946.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 14Combined sources5
Turni15 – 18Combined sources4
Beta strandi19 – 23Combined sources5
Beta strandi25 – 27Combined sources3
Beta strandi29 – 31Combined sources3
Helixi36 – 38Combined sources3
Helixi41 – 44Combined sources4
Helixi51 – 64Combined sources14
Beta strandi67 – 69Combined sources3
Helixi71 – 87Combined sources17
Beta strandi112 – 117Combined sources6
Turni118 – 120Combined sources3
Beta strandi123 – 131Combined sources9
Beta strandi133 – 140Combined sources8
Beta strandi142 – 147Combined sources6
Beta strandi150 – 153Combined sources4
Beta strandi157 – 161Combined sources5
Helixi162 – 164Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E1LX-ray2.15A1-180[»]
5FO3X-ray2.90A/B1-180[»]
ProteinModelPortaliP75862.
SMRiP75862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZapC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108T7E. Bacteria.
ENOG410YF51. LUCA.
HOGENOMiHOG000277864.
KOiK18657.
OMAiDNWRWYF.

Family and domain databases

HAMAPiMF_00906. ZapC. 1 hit.
InterProiIPR009809. ZapC.
[Graphical view]
PfamiPF07126. ZapC. 1 hit.
[Graphical view]
PIRSFiPIRSF010252. ZapC. 1 hit.

Sequencei

Sequence statusi: Complete.

P75862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKPDDNWR WYYDEEHDRM MLDLANGMLF RSRFARKMLT PDAFSPAGFC
60 70 80 90 100
VDDAALYFSF EEKCRDFNLS KEQKAELVLN ALVAIRYLKP QMPKSWHFVS
110 120 130 140 150
HGEMWVPMPG DAACVWLSDT HEQVNLLVVE SGENAALCLL AQPCVVIAGR
160 170 180
AMQLGDAIKI MNDRLKPQVN VDSFSLEQAV
Length:180
Mass (Da):20,589
Last modified:December 1, 2000 - v2
Checksum:i7A8CC66ECE2D1B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74032.2.
AP009048 Genomic DNA. Translation: BAA35701.2.
PIRiA64835.
RefSeqiNP_415466.4. NC_000913.3.
WP_001295353.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74032; AAC74032; b0946.
BAA35701; BAA35701; BAA35701.
GeneIDi945552.
KEGGiecj:JW5125.
eco:b0946.
PATRICi32117111. VBIEscCol129921_0980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74032.2.
AP009048 Genomic DNA. Translation: BAA35701.2.
PIRiA64835.
RefSeqiNP_415466.4. NC_000913.3.
WP_001295353.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E1LX-ray2.15A1-180[»]
5FO3X-ray2.90A/B1-180[»]
ProteinModelPortaliP75862.
SMRiP75862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259444. 7 interactors.
DIPiDIP-11485N.
IntActiP75862. 22 interactors.
MINTiMINT-1227819.
STRINGi511145.b0946.

Proteomic databases

PaxDbiP75862.
PRIDEiP75862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74032; AAC74032; b0946.
BAA35701; BAA35701; BAA35701.
GeneIDi945552.
KEGGiecj:JW5125.
eco:b0946.
PATRICi32117111. VBIEscCol129921_0980.

Organism-specific databases

EchoBASEiEB3479.
EcoGeneiEG13715. zapC.

Phylogenomic databases

eggNOGiENOG4108T7E. Bacteria.
ENOG410YF51. LUCA.
HOGENOMiHOG000277864.
KOiK18657.
OMAiDNWRWYF.

Enzyme and pathway databases

BioCyciEcoCyc:G6486-MONOMER.
ECOL316407:JW5125-MONOMER.

Miscellaneous databases

PROiP75862.

Family and domain databases

HAMAPiMF_00906. ZapC. 1 hit.
InterProiIPR009809. ZapC.
[Graphical view]
PfamiPF07126. ZapC. 1 hit.
[Graphical view]
PIRSFiPIRSF010252. ZapC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZAPC_ECOLI
AccessioniPrimary (citable) accession number: P75862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.