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Protein

Cell division protein ZapC

Gene

zapC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.UniRule annotation2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
  • regulation of cell division Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciEcoCyc:G6486-MONOMER.
ECOL316407:JW5125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein ZapCUniRule annotation
Alternative name(s):
FtsZ-associated protein C
Z-ring-associated protein C
Gene namesi
Name:zapCUniRule annotation
Synonyms:ycbW
Ordered Locus Names:b0946, JW5125
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13715. zapC.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants divide almost normally under standard growth conditions.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi22 – 221L → P: Does not interact with FtsZ, but shows affinity for itself. Reduces GTPase activity by less than 10%. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Cell division protein ZapCPRO_0000168778Add
BLAST

Proteomic databases

PaxDbiP75862.
PRIDEiP75862.

Interactioni

Subunit structurei

Interacts directly with FtsZ. Monomer in solution.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-552519,EBI-552519
ftsZP0A9A65EBI-552519,EBI-370963

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259444. 7 interactions.
DIPiDIP-11485N.
IntActiP75862. 22 interactions.
MINTiMINT-1227819.
STRINGi511145.b0946.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 145Combined sources
Turni15 – 184Combined sources
Beta strandi19 – 235Combined sources
Beta strandi25 – 273Combined sources
Beta strandi29 – 313Combined sources
Helixi36 – 383Combined sources
Helixi41 – 444Combined sources
Helixi51 – 6414Combined sources
Beta strandi67 – 693Combined sources
Helixi71 – 8717Combined sources
Beta strandi112 – 1176Combined sources
Turni118 – 1203Combined sources
Beta strandi123 – 1319Combined sources
Beta strandi133 – 1408Combined sources
Beta strandi142 – 1476Combined sources
Beta strandi150 – 1534Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 1643Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5E1LX-ray2.15A1-180[»]
5FO3X-ray2.90A/B1-180[»]
ProteinModelPortaliP75862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZapC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108T7E. Bacteria.
ENOG410YF51. LUCA.
HOGENOMiHOG000277864.
KOiK18657.
OMAiDNWRWYF.

Family and domain databases

HAMAPiMF_00906. ZapC. 1 hit.
InterProiIPR009809. ZapC.
[Graphical view]
PfamiPF07126. ZapC. 1 hit.
[Graphical view]
PIRSFiPIRSF010252. ZapC. 1 hit.

Sequencei

Sequence statusi: Complete.

P75862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIKPDDNWR WYYDEEHDRM MLDLANGMLF RSRFARKMLT PDAFSPAGFC
60 70 80 90 100
VDDAALYFSF EEKCRDFNLS KEQKAELVLN ALVAIRYLKP QMPKSWHFVS
110 120 130 140 150
HGEMWVPMPG DAACVWLSDT HEQVNLLVVE SGENAALCLL AQPCVVIAGR
160 170 180
AMQLGDAIKI MNDRLKPQVN VDSFSLEQAV
Length:180
Mass (Da):20,589
Last modified:December 1, 2000 - v2
Checksum:i7A8CC66ECE2D1B87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74032.2.
AP009048 Genomic DNA. Translation: BAA35701.2.
PIRiA64835.
RefSeqiNP_415466.4. NC_000913.3.
WP_001295353.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74032; AAC74032; b0946.
BAA35701; BAA35701; BAA35701.
GeneIDi945552.
KEGGiecj:JW5125.
eco:b0946.
PATRICi32117111. VBIEscCol129921_0980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74032.2.
AP009048 Genomic DNA. Translation: BAA35701.2.
PIRiA64835.
RefSeqiNP_415466.4. NC_000913.3.
WP_001295353.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5E1LX-ray2.15A1-180[»]
5FO3X-ray2.90A/B1-180[»]
ProteinModelPortaliP75862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259444. 7 interactions.
DIPiDIP-11485N.
IntActiP75862. 22 interactions.
MINTiMINT-1227819.
STRINGi511145.b0946.

Proteomic databases

PaxDbiP75862.
PRIDEiP75862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74032; AAC74032; b0946.
BAA35701; BAA35701; BAA35701.
GeneIDi945552.
KEGGiecj:JW5125.
eco:b0946.
PATRICi32117111. VBIEscCol129921_0980.

Organism-specific databases

EchoBASEiEB3479.
EcoGeneiEG13715. zapC.

Phylogenomic databases

eggNOGiENOG4108T7E. Bacteria.
ENOG410YF51. LUCA.
HOGENOMiHOG000277864.
KOiK18657.
OMAiDNWRWYF.

Enzyme and pathway databases

BioCyciEcoCyc:G6486-MONOMER.
ECOL316407:JW5125-MONOMER.

Miscellaneous databases

PROiP75862.

Family and domain databases

HAMAPiMF_00906. ZapC. 1 hit.
InterProiIPR009809. ZapC.
[Graphical view]
PfamiPF07126. ZapC. 1 hit.
[Graphical view]
PIRSFiPIRSF010252. ZapC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZAPC_ECOLI
AccessioniPrimary (citable) accession number: P75862
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.