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Protein

Probable fimbrial chaperone protein ElfD

Gene

elfD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell wall organization Source: InterPro
  • chaperone-mediated protein folding Source: GO_Central
  • pilus organization Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6481-MONOMER.
ECOL316407:JW0922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone protein ElfD
Gene namesi
Name:elfD
Synonyms:ycbR
Ordered Locus Names:b0939, JW0922
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13710. elfD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000929227 – 233Probable fimbrial chaperone protein ElfDAdd BLAST207

Proteomic databases

PaxDbiP75856.
PRIDEiP75856.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4262112. 119 interactors.
IntActiP75856. 3 interactors.
STRINGi511145.b0939.

Structurei

3D structure databases

ProteinModelPortaliP75856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4106JJN. Bacteria.
COG3121. LUCA.
HOGENOMiHOG000260152.
OMAiMGAKNSS.
PhylomeDBiP75856.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P75856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTCITKGIV TVSLTAILLS CSSAWAAGKG GIGLAATRLV YSEGEEQISL
60 70 80 90 100
GVRNTSPDVP YLIQSWVMTP DNKKSADFII TPPLFVLNPA NENLLRIMYI
110 120 130 140 150
GAPLAKDRET LFFTSVRAVP STTKRKEGNT LKIATQSVIK LFWRPKGLAY
160 170 180 190 200
PLGEAPAKLR CTSSADMVTV SNPTPYFITL TDLKIGGKVV KNQMISPFDK
210 220 230
YQFSLPKGAK NSSVTYRTIN DYGAETPQLN CKS
Length:233
Mass (Da):25,389
Last modified:February 1, 1997 - v1
Checksum:i1B18AB3806077C76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74025.1.
AP009048 Genomic DNA. Translation: BAA35694.1.
PIRiB64834.
RefSeqiNP_415459.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC74025; AAC74025; b0939.
BAA35694; BAA35694; BAA35694.
GeneIDi946773.
KEGGiecj:JW0922.
eco:b0939.
PATRICi32117097. VBIEscCol129921_0973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74025.1.
AP009048 Genomic DNA. Translation: BAA35694.1.
PIRiB64834.
RefSeqiNP_415459.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP75856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262112. 119 interactors.
IntActiP75856. 3 interactors.
STRINGi511145.b0939.

Proteomic databases

PaxDbiP75856.
PRIDEiP75856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74025; AAC74025; b0939.
BAA35694; BAA35694; BAA35694.
GeneIDi946773.
KEGGiecj:JW0922.
eco:b0939.
PATRICi32117097. VBIEscCol129921_0973.

Organism-specific databases

EchoBASEiEB3474.
EcoGeneiEG13710. elfD.

Phylogenomic databases

eggNOGiENOG4106JJN. Bacteria.
COG3121. LUCA.
HOGENOMiHOG000260152.
OMAiMGAKNSS.
PhylomeDBiP75856.

Enzyme and pathway databases

BioCyciEcoCyc:G6481-MONOMER.
ECOL316407:JW0922-MONOMER.

Miscellaneous databases

PROiP75856.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELFD_ECOLI
AccessioniPrimary (citable) accession number: P75856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.