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Protein

Uncharacterized protein YcbL

Gene

ycbL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Zinc 1; via tele nitrogenBy similarity
Metal bindingi58 – 581Zinc 1; via pros nitrogenBy similarity
Metal bindingi60 – 601Zinc 2By similarity
Metal bindingi61 – 611Zinc 2; via tele nitrogenBy similarity
Metal bindingi132 – 1321Zinc 1; via tele nitrogenBy similarity
Metal bindingi151 – 1511Zinc 1By similarity
Metal bindingi151 – 1511Zinc 2By similarity
Metal bindingi192 – 1921Zinc 2; via tele nitrogenBy similarity

GO - Molecular functioni

  • hydroxyacylglutathione hydrolase activity Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G6475-MONOMER.
ECOL316407:JW0910-MONOMER.
RETL1328306-WGS:GSTH-3055-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein YcbL (EC:3.-.-.-)
Gene namesi
Name:ycbL
Ordered Locus Names:b0927, JW0910
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13704. ycbL.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Uncharacterized protein YcbLPRO_0000192357Add
BLAST

Proteomic databases

EPDiP75849.
PaxDbiP75849.
PRIDEiP75849.

Interactioni

Protein-protein interaction databases

BioGridi4261607. 16 interactions.
DIPiDIP-11480N.
IntActiP75849. 4 interactions.
MINTiMINT-1282138.
STRINGi511145.b0927.

Structurei

3D structure databases

ProteinModelPortaliP75849.
SMRiP75849. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C5X. Bacteria.
COG0491. LUCA.
HOGENOMiHOG000058039.
InParanoidiP75849.
OMAiTPDRWLE.
PhylomeDBiP75849.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

P75849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYRIIPVTA FSQNCSLIWC EQTRLAALVD PGGDAEKIKQ EVDDSGLTLM
60 70 80 90 100
QILLTHGHLD HVGAAAELAQ HYGVPVFGPE KEDEFWLQGL PAQSRMFGLE
110 120 130 140 150
ECQPLTPDRW LNEGDTISIG NVTLQVLHCP GHTPGHVVFF DDRAKLLISG
160 170 180 190 200
DVIFKGGVGR SDFPRGDHNQ LISSIKDKLL PLGDDVIFIP GHGPLSTLGY
210
ERLHNPFLQD EMPVW
Length:215
Mass (Da):23,784
Last modified:February 1, 1997 - v1
Checksum:iC4233FF08308B18D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74013.1.
AP009048 Genomic DNA. Translation: BAA35673.1.
PIRiF64832.
RefSeqiNP_415447.1. NC_000913.3.
WP_001109486.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74013; AAC74013; b0927.
BAA35673; BAA35673; BAA35673.
GeneIDi945551.
KEGGiecj:JW0910.
eco:b0927.
PATRICi32117067. VBIEscCol129921_0958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74013.1.
AP009048 Genomic DNA. Translation: BAA35673.1.
PIRiF64832.
RefSeqiNP_415447.1. NC_000913.3.
WP_001109486.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75849.
SMRiP75849. Positions 1-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261607. 16 interactions.
DIPiDIP-11480N.
IntActiP75849. 4 interactions.
MINTiMINT-1282138.
STRINGi511145.b0927.

Proteomic databases

EPDiP75849.
PaxDbiP75849.
PRIDEiP75849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74013; AAC74013; b0927.
BAA35673; BAA35673; BAA35673.
GeneIDi945551.
KEGGiecj:JW0910.
eco:b0927.
PATRICi32117067. VBIEscCol129921_0958.

Organism-specific databases

EchoBASEiEB3468.
EcoGeneiEG13704. ycbL.

Phylogenomic databases

eggNOGiENOG4105C5X. Bacteria.
COG0491. LUCA.
HOGENOMiHOG000058039.
InParanoidiP75849.
OMAiTPDRWLE.
PhylomeDBiP75849.

Enzyme and pathway databases

BioCyciEcoCyc:G6475-MONOMER.
ECOL316407:JW0910-MONOMER.
RETL1328306-WGS:GSTH-3055-MONOMER.

Miscellaneous databases

PROiP75849.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYCBL_ECOLI
AccessioniPrimary (citable) accession number: P75849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.