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Protein

Inner membrane transporter YcaM

Gene

ycaM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YCAM.
ECOL316407:JW5119-MONOMER.

Protein family/group databases

TCDBi2.A.3.7.2. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane transporter YcaM
Gene namesi
Name:ycaM
Ordered Locus Names:b0899, JW5119
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13697. ycaM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 38PeriplasmicSequence analysis8
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 80CytoplasmicSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 125PeriplasmicSequence analysisAdd BLAST24
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 154CytoplasmicSequence analysis8
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 195PeriplasmicSequence analysisAdd BLAST20
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 291PeriplasmicSequence analysisAdd BLAST30
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 343CytoplasmicSequence analysisAdd BLAST31
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 375PeriplasmicSequence analysisAdd BLAST11
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 414CytoplasmicSequence analysisAdd BLAST18
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 448PeriplasmicSequence analysisAdd BLAST13
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 476CytoplasmicSequence analysis7

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002130441 – 476Inner membrane transporter YcaMAdd BLAST476

Proteomic databases

PaxDbiP75835.
PRIDEiP75835.

Interactioni

Protein-protein interaction databases

BioGridi4261113. 104 interactors.
DIPiDIP-11468N.
STRINGi511145.b0899.

Structurei

3D structure databases

ProteinModelPortaliP75835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E5D. Bacteria.
COG0531. LUCA.
HOGENOMiHOG000057650.
InParanoidiP75835.
OMAiYLAGWTY.
PhylomeDBiP75835.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P75835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNVQEKQL RWYNIALMSF ITVWGFGNVV NNYANQGLVV VFSWVFIFAL
60 70 80 90 100
YFTPYALIVG QLGSTFKDGK GGVSTWIKHT MGPGLAYLAA WTYWVVHIPY
110 120 130 140 150
LAQKPQAILI ALGWAMKGDG SLIKEYSVVA LQGLTLVLFI FFMWVASRGM
160 170 180 190 200
KSLKIVGSVA GIAMFVMSLL YVAMAVTAPA ITEVHIATTN ITWETFIPHI
210 220 230 240 250
DFTYITTISM LVFAVGGAEK ISPYVNQTRN PGKEFPKGML CLAVMVAVCA
260 270 280 290 300
ILGSLAMGMM FDSRNIPDDL MTNGQYYAFQ KLGEYYNMGN TLMVIYAIAN
310 320 330 340 350
TLGQVAALVF SIDAPLKVLL GDADSKYIPA SLCRTNASGT PVNGYFLTLV
360 370 380 390 400
LVAILIMLPT LGIGDMNNLY KWLLNLNSVV MPLRYLWVFV AFIAVVRLAQ
410 420 430 440 450
KYKPEYVFIR NKPLAMTVGI WCFAFTAFAC LTGIFPKMEA FTAEWTFQLA
460 470
LNVATPFVLV GLGLIFPLLA RKANSK
Length:476
Mass (Da):52,496
Last modified:May 30, 2000 - v2
Checksum:iEEE28BE119576B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73985.2.
AP009048 Genomic DNA. Translation: BAA35634.2.
PIRiB64829.
RefSeqiNP_415419.2. NC_000913.3.
WP_000918506.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73985; AAC73985; b0899.
BAA35634; BAA35634; BAA35634.
GeneIDi945518.
KEGGiecj:JW5119.
eco:b0899.
PATRICi32117011. VBIEscCol129921_0930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73985.2.
AP009048 Genomic DNA. Translation: BAA35634.2.
PIRiB64829.
RefSeqiNP_415419.2. NC_000913.3.
WP_000918506.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261113. 104 interactors.
DIPiDIP-11468N.
STRINGi511145.b0899.

Protein family/group databases

TCDBi2.A.3.7.2. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP75835.
PRIDEiP75835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73985; AAC73985; b0899.
BAA35634; BAA35634; BAA35634.
GeneIDi945518.
KEGGiecj:JW5119.
eco:b0899.
PATRICi32117011. VBIEscCol129921_0930.

Organism-specific databases

EchoBASEiEB3461.
EcoGeneiEG13697. ycaM.

Phylogenomic databases

eggNOGiENOG4105E5D. Bacteria.
COG0531. LUCA.
HOGENOMiHOG000057650.
InParanoidiP75835.
OMAiYLAGWTY.
PhylomeDBiP75835.

Enzyme and pathway databases

BioCyciEcoCyc:YCAM.
ECOL316407:JW5119-MONOMER.

Miscellaneous databases

PROiP75835.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYCAM_ECOLI
AccessioniPrimary (citable) accession number: P75835
Secondary accession number(s): Q9R7Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.