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Protein

Lysine exporter LysO

Gene

lysO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates export of lysine.1 Publication

GO - Molecular functioni

  • L-lysine efflux transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • L-lysine transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6458-MONOMER.
ECOL316407:JW0858-MONOMER.
MetaCyc:G6458-MONOMER.

Protein family/group databases

TCDBi2.A.124.1.1. the lysine exporter (lyso) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine exporter LysOCurated
Alternative name(s):
Lys outward permease1 Publication
Gene namesi
Name:lysO1 Publication
Synonyms:ybjE
Ordered Locus Names:b0874, JW0858
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13426. ybjE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Null mutant is hypersensitive to the lysine antimetabolite thialysine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687371 – 299Lysine exporter LysOAdd BLAST299

Proteomic databases

PaxDbiP75826.
PRIDEiP75826.

Expressioni

Inductioni

Repressed by arginine, via the ArgR repressor.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259999. 15 interactors.
DIPiDIP-11447N.
IntActiP75826. 2 interactors.
MINTiMINT-1248567.
STRINGi511145.b0874.

Structurei

3D structure databases

ProteinModelPortaliP75826.
SMRiP75826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LysO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWU. Bacteria.
COG2431. LUCA.
HOGENOMiHOG000275902.
InParanoidiP75826.
OMAiMLFIFAP.

Family and domain databases

InterProiIPR005642. LysO.
[Graphical view]
PfamiPF03956. DUF340. 1 hit.
[Graphical view]
ProDomiPD022789. DUF340_prk_mem. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P75826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGLLIILV PLIVGYLIPL RQQAALKVIN QLLSWMVYLI LFFMGISLAF
60 70 80 90 100
LDNLASNLLA ILHYSAVSIT VILLCNIAAL MWLERGLPWR NHHQQEKLPS
110 120 130 140 150
RIAMALESLK LCGVVVIGFA IGLSGLAFLQ HATEASEYTL ILLLFLVGIQ
160 170 180 190 200
LRNNGMTLKQ IVLNRRGMIV AVVVVVSSLI GGLINAFILD LPINTALAMA
210 220 230 240 250
SGFGWYSLSG ILLTESFGPV IGSAAFFNDL ARELIAIMLI PGLIRRSRST
260 270 280 290
ALGLCGATSM DFTLPVLQRT GGLDMVPAAI VHGFILSLLV PILIAFFSA
Length:299
Mass (Da):32,340
Last modified:April 27, 2001 - v2
Checksum:iD413F61566C34241
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73961.2.
AP009048 Genomic DNA. Translation: BAA35588.1.
RefSeqiNP_415395.2. NC_000913.3.
WP_000491142.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73961; AAC73961; b0874.
BAA35588; BAA35588; BAA35588.
GeneIDi947142.
KEGGiecj:JW0858.
eco:b0874.
PATRICi32116955. VBIEscCol129921_0903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73961.2.
AP009048 Genomic DNA. Translation: BAA35588.1.
RefSeqiNP_415395.2. NC_000913.3.
WP_000491142.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP75826.
SMRiP75826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259999. 15 interactors.
DIPiDIP-11447N.
IntActiP75826. 2 interactors.
MINTiMINT-1248567.
STRINGi511145.b0874.

Protein family/group databases

TCDBi2.A.124.1.1. the lysine exporter (lyso) family.

Proteomic databases

PaxDbiP75826.
PRIDEiP75826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73961; AAC73961; b0874.
BAA35588; BAA35588; BAA35588.
GeneIDi947142.
KEGGiecj:JW0858.
eco:b0874.
PATRICi32116955. VBIEscCol129921_0903.

Organism-specific databases

EchoBASEiEB3200.
EcoGeneiEG13426. ybjE.

Phylogenomic databases

eggNOGiENOG4105DWU. Bacteria.
COG2431. LUCA.
HOGENOMiHOG000275902.
InParanoidiP75826.
OMAiMLFIFAP.

Enzyme and pathway databases

BioCyciEcoCyc:G6458-MONOMER.
ECOL316407:JW0858-MONOMER.
MetaCyc:G6458-MONOMER.

Miscellaneous databases

PROiP75826.

Family and domain databases

InterProiIPR005642. LysO.
[Graphical view]
PfamiPF03956. DUF340. 1 hit.
[Graphical view]
ProDomiPD022789. DUF340_prk_mem. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiLYSO_ECOLI
AccessioniPrimary (citable) accession number: P75826
Secondary accession number(s): Q9R2W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.