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Protein

Lysine exporter LysO

Gene

lysO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates export of lysine.1 Publication

GO - Molecular functioni

  • L-lysine efflux transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • L-lysine transmembrane transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6458-MONOMER
MetaCyc:G6458-MONOMER

Protein family/group databases

TCDBi2.A.124.1.1 the lysine exporter (lyso) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine exporter LysOCurated
Alternative name(s):
Lys outward permease1 Publication
Gene namesi
Name:lysO1 Publication
Synonyms:ybjE
Ordered Locus Names:b0874, JW0858
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13426 ybjE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Null mutant is hypersensitive to the lysine antimetabolite thialysine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687371 – 299Lysine exporter LysOAdd BLAST299

Proteomic databases

PaxDbiP75826
PRIDEiP75826

Expressioni

Inductioni

Repressed by arginine, via the ArgR repressor.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259999, 17 interactors
DIPiDIP-11447N
IntActiP75826, 2 interactors
STRINGi316385.ECDH10B_0944

Structurei

3D structure databases

ProteinModelPortaliP75826
SMRiP75826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LysO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWU Bacteria
COG2431 LUCA
HOGENOMiHOG000275902
InParanoidiP75826
OMAiIFITEYK

Family and domain databases

InterProiView protein in InterPro
IPR005642 LysO
PANTHERiPTHR35804 PTHR35804, 1 hit
PfamiView protein in Pfam
PF03956 Lys_export, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022789 DUF340_prk_mem, 1 hit

Sequencei

Sequence statusi: Complete.

P75826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSGLLIILV PLIVGYLIPL RQQAALKVIN QLLSWMVYLI LFFMGISLAF
60 70 80 90 100
LDNLASNLLA ILHYSAVSIT VILLCNIAAL MWLERGLPWR NHHQQEKLPS
110 120 130 140 150
RIAMALESLK LCGVVVIGFA IGLSGLAFLQ HATEASEYTL ILLLFLVGIQ
160 170 180 190 200
LRNNGMTLKQ IVLNRRGMIV AVVVVVSSLI GGLINAFILD LPINTALAMA
210 220 230 240 250
SGFGWYSLSG ILLTESFGPV IGSAAFFNDL ARELIAIMLI PGLIRRSRST
260 270 280 290
ALGLCGATSM DFTLPVLQRT GGLDMVPAAI VHGFILSLLV PILIAFFSA
Length:299
Mass (Da):32,340
Last modified:April 27, 2001 - v2
Checksum:iD413F61566C34241
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73961.2
AP009048 Genomic DNA Translation: BAA35588.1
RefSeqiNP_415395.2, NC_000913.3
WP_000491142.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73961; AAC73961; b0874
BAA35588; BAA35588; BAA35588
GeneIDi947142
KEGGiecj:JW0858
eco:b0874
PATRICifig|1411691.4.peg.1403

Similar proteinsi

Entry informationi

Entry nameiLYSO_ECOLI
AccessioniPrimary (citable) accession number: P75826
Secondary accession number(s): Q9R2W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health